Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S2462 Donepezil HCl 5 mg/mL <1 mg/mL <1 mg/mL
S2251 (-)-Huperzine A (HupA) <1 mg/mL 0.66 mg/mL <1 mg/mL
S5900 Edrophonium chloride 40 mg/mL 40 mg/mL 10 mg/mL
S9252 Corydaline -1 mg/mL 74 mg/mL -1 mg/mL
S9260 Nodakenin -1 mg/mL 82 mg/mL -1 mg/mL
S9219 Huperzine B -1 mg/mL 10 mg/mL -1 mg/mL
s9138 Picfeltarraenin IA -1 mg/mL 100 mg/mL -1 mg/mL
S9154 Chelidonine -1 mg/mL 5 mg/mL -1 mg/mL
s9087 Tenuifolin -1 mg/mL 100 mg/mL -1 mg/mL
s9069 Jatrorrhizine chloride -1 mg/mL 4 mg/mL -1 mg/mL
S5493 Atropine sulfate -1 mg/mL 18 mg/mL -1 mg/mL
S5511 Ethyl (triphenylphosphoranylidene) acetate -1 mg/mL 69 mg/mL -1 mg/mL
S5073 Donepezil -1 mg/mL 75 mg/mL -1 mg/mL
S5075 Acotiamide <1 mg/mL 90 mg/mL 38 mg/mL
S4838 Acotiamide hydrochloride 5 mg/mL 100 mg/mL 20 mg/mL
S4776 Harmaline -1 mg/mL 23 mg/mL -1 mg/mL
S3903 Lycorine -1 mg/mL 57 mg/mL -1 mg/mL
S3866 Galanthamine 57 mg/mL 100 mg/mL -1 mg/mL
S3884 Jatrorrhizine -1 mg/mL 67 mg/mL -1 mg/mL
S2452 Amfebutamone (Bupropion) HCl <1 mg/mL 8 mg/mL <1 mg/mL
S1339 Galanthamine HBr 36 mg/mL <1 mg/mL <1 mg/mL
S4031 Aclidinium Bromide <1 mg/mL 113 mg/mL <1 mg/mL
S1397 Rocuronium Bromide 122 mg/mL 122 mg/mL 122 mg/mL
S3047 Otilonium Bromide 113 mg/mL 113 mg/mL 113 mg/mL
S2471 Gallamine Triethiodide 100 mg/mL 100 mg/mL <1 mg/mL
S1608 Pyridostigmine Bromide 52 mg/mL 52 mg/mL 52 mg/mL
S2087 Rivastigmine Tartrate 80 mg/mL 42 mg/mL 80 mg/mL
S1929 Irsogladine <1 mg/mL 2 mg/mL <1 mg/mL
S2490 Neostigmine Bromide 60 mg/mL <1 mg/mL <1 mg/mL
S3202 Catharanthine <1 mg/mL 67 mg/mL 3 mg/mL
S4014 Hyoscyamine <1 mg/mL 58 mg/mL 58 mg/mL
S4023 Procaine HCl 55 mg/mL 55 mg/mL <1 mg/mL
S3820 Dehydroevodiamine hydrochloride -1 mg/mL 37 mg/mL -1 mg/mL
S1832 Atracurium Besylate 33 mg/mL 100 mg/mL 100 mg/mL
S3835 Loganin -1 mg/mL 78 mg/mL -1 mg/mL
S4619 Itopride hydrochloride 78 mg/mL 78 mg/mL 38 mg/mL
S4162 Benzethonium Chloride 90 mg/mL 90 mg/mL 90 mg/mL
S3639 Tacrine hydrochloride hydrate 50 mg/mL 50 mg/mL 50 mg/mL
S3662 Pirenzepine dihydrochloride 84 mg/mL 1 mg/mL <1 mg/mL
S3769 Palmatine -1 mg/mL 70 mg/mL -1 mg/mL
S4505 Vinblastine sulfate <1 mg/mL 100 mg/mL <1 mg/mL
S4542 Trihexyphenidyl hydrochloride <1 mg/mL 7 mg/mL 24 mg/mL
S2082 Adiphenine HCl 70 mg/mL 30 mg/mL 18 mg/mL
S5100 Pralidoxime Iodide -1 mg/mL 52 mg/mL -1 mg/mL
S4575 Pralidoxime chloride 34 mg/mL <1 mg/mL 1 mg/mL
S2547 Tiotropium Bromide hydrate <1 mg/mL 8 mg/mL <1 mg/mL
S2497 Pancuronium dibromide 100 mg/mL 100 mg/mL 100 mg/mL
S2550 Tolterodine tartrate 17 mg/mL 95 mg/mL 6 mg/mL
S5699 Scopolamine N-Oxide HydrobroMide Monohydrate 7 mg/mL 84 mg/mL <1 mg/mL
S5238 Solifenacin (YM905) -1 mg/mL 72 mg/mL -1 mg/mL
S5480 Clidinium Bromide -1 mg/mL 86 mg/mL -1 mg/mL
S5538 Tropisetron 56 mg/mL 10 mg/mL -1 mg/mL
S5258 Revefenacin <1 mg/mL 100 mg/mL 100 mg/mL
S4834 Propantheline bromide -1 mg/mL 89 mg/mL -1 mg/mL
S4623 Methylbenactyzine Bromide 84 mg/mL 84 mg/mL 84 mg/mL
S2240 Fesoterodine Fumarate 100 mg/mL 100 mg/mL 100 mg/mL
S1754 Oxybutynin <1 mg/mL 71 mg/mL 71 mg/mL
S3048 Solifenacin succinate 96 mg/mL 3 mg/mL 5 mg/mL
S1683 Ipratropium Bromide 83 mg/mL 83 mg/mL 83 mg/mL
S2549 Trospium chloride 86 mg/mL 41 mg/mL 42 mg/mL
S2130 Atropine sulfate monohydrate 139 mg/mL 139 mg/mL 139 mg/mL
S1978 Methscopolamine 67 mg/mL 79 mg/mL <1 mg/mL
S2508 Scopolamine HBr 76 mg/mL 76 mg/mL <1 mg/mL
S2659 5-hydroxymethyl Tolterodine (PNU 200577, 5-HMT, 5-HM) <1 mg/mL 68 mg/mL 68 mg/mL
S3144 Darifenacin HBr <1 mg/mL 100 mg/mL <1 mg/mL
S4024 Homatropine Methylbromide 74 mg/mL 74 mg/mL 10 mg/mL
S4025 Homatropine Bromide 71 mg/mL 71 mg/mL <1 mg/mL
S4027 Flavoxate HCl 10 mg/mL 3 mg/mL <1 mg/mL
S2054 Orphenadrine Citrate <1 mg/mL 92 mg/mL <1 mg/mL
S4034 Diphemanil Methylsulfate 28 mg/mL 25 mg/mL <1 mg/mL
S4143 Pentoxyverine Citrate 100 mg/mL 100 mg/mL 8 mg/mL
S3701 Benactyzine hydrochloride 72 mg/mL 72 mg/mL 72 mg/mL
S4069 Hexamethonium Dibromide 73 mg/mL <1 mg/mL <1 mg/mL
S4660 Glycopyrrolate 79 mg/mL 65 mg/mL 59 mg/mL
S3735 Umeclidinium bromide <1 mg/mL 100 mg/mL 12 mg/mL
S3117 Oxybutynin hydrochloride 4 mg/mL 79 mg/mL 79 mg/mL
S4292 Diphenidol HCl 13 mg/mL 69 mg/mL 36 mg/mL
S1913 Tropicamide <1 mg/mL 57 mg/mL 57 mg/mL
S5930 PNU 282987 11 mg/mL 46 mg/mL 4 mg/mL
S1805 Acetylcholine Chloride 36 mg/mL 36 mg/mL 36 mg/mL
S1440 Varenicline Tartrate 72 mg/mL 1 mg/mL <1 mg/mL
S2455 Bethanechol chloride 39 mg/mL 39 mg/mL 39 mg/mL
S2614 Arecoline HBr 47 mg/mL 47 mg/mL 10 mg/mL
S4231 Pilocarpine HCl 48 mg/mL 48 mg/mL 48 mg/mL
S4121 Succinylcholine Chloride Dihydrate 79 mg/mL 1 mg/mL <1 mg/mL
S4422 Nitenpyram 54 mg/mL 54 mg/mL 54 mg/mL
S7366 LY2119620 <1 mg/mL 87 mg/mL 10 mg/mL
S2287 Cytisine 38 mg/mL 38 mg/mL 38 mg/mL
S4171 Choline Chloride 28 mg/mL 28 mg/mL 28 mg/mL
S4072 Decamethonium Bromide 84 mg/mL 34 mg/mL 25 mg/mL
S3684 Methacholine chloride 39 mg/mL 39 mg/mL 39 mg/mL
S4718 Acetylcholine iodide 54 mg/mL 54 mg/mL 54 mg/mL
S5931 BQCA <1 mg/mL 13 mg/mL <1 mg/mL
S5747 Morantel tartrate -1 mg/mL 74 mg/mL -1 mg/mL
S3972 Lobeline hydrochloride -1 mg/mL 74 mg/mL -1 mg/mL
S2629 PNU-120596 <1 mg/mL 62 mg/mL 1 mg/mL
S1405 Vecuronium Bromide 4 mg/mL 100 mg/mL 100 mg/mL
S4617 Dextromethorphan hydrobromide hydrate <1 mg/mL 74 mg/mL 74 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations

Donepezil HCl

Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.


(-)-Huperzine A (HupA)

(-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with Ki of 7 nM, exhibiting 200-fold more selectivity for G4 AChE over G1 AChE. Also acts as an NMDA receptor antagonist. Phase 4.


Edrophonium chloride

Edrophonium chloride is the chloride salt of edrophonium, which is a rapid-onset, short-acting, readily reversible inhibitor of acetylcholinesterase.



Corydaline is a bioactive alkaloid with various anti-acetylcholinesterase, anti-allergic, and anti-nociceptive activities found in the medicinal herb Corydalis Tubers.



Nodakenin, a coumarin compound, acts as an AChE inhibitor that inhibits AChE activity in a dosedependent manner with an IC50 value of 84.7 μM.


Huperzine B

Huperzine B, a natural alkaloid existed in Lycopodium plants, is a novel acetylcholinesterase inhibitor and has neuroprotective effects.


Picfeltarraenin IA

Picfeltarraenin IA is an AChE inhibitior, and an potential PI3K and EGFR inhibitor. It also acts as an inhibitor on both the classical and alternative pathways of the complement system.



Chelidonine, a major bioactive, isoquinoline alkaloid ingredient in Chelidonium majus, exhibits anti-inflammatory properties and acetylcholinesterase and butyrylcholinesterase inhibitory activity.



Tenuifolin, a secondary saponin isolated from hydrolysates of polygalasaponins, inhibits beta-amyloid synthesis in vitro and has nootropic activity in vivo via acetylcholine esterase inhibition and increases norepinephrine and dopamine production.


Jatrorrhizine chloride

Jatrorrhizine chloride is the hydrochloride salt form of jatrorrhizine, which is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.


Atropine sulfate

Atropine Sulfate is the sulfate salt of atropine, which is a natural alkaloid anticholinergic agent and has potent antimuscarinic effects.


Ethyl (triphenylphosphoranylidene) acetate

Ethyl (triphenylphosphoranylidene) acetate may act as an inhibitor of cholinesterase that inhibits AChE and BChE.



Donepezil is a piperidine based, potent, specific, non-competitive and reversible inhibitor of acetylcholinesterase (AChE) used for the treatment of mild to moderate dementia of the Alzheimer's type.



Acotiamide is a novel acetylcholinesterase inhibitor with fundus-relaxing and gastroprokinetic properties.


Acotiamide hydrochloride

Acotiamide Hydrochloride is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. It is a new orally active selective acetylcholinesterase inhibitor.



Harmaline, a natural occurrence β-carboline alkaloid, is a central nervous system stimulant and an acetylcholinesterase (AChR) inhibitor; also inhibits histamine N-methyltransferase.



Lycorine is a toxic crystalline alkaloid found in various Amaryllidaceae species that weakly inhibits acetylcholinesterase (AChE) and ascorbic acid biosynthesis.



Galantamine is a phenanthrene alkaloid and a reversible, competitive acetylcholinesterase inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase. It is studied as a treatment for Alzheimer's disease and other central nervous system disorders.



Jatrorrhizine, one of the active constituents of Coptis chinensis Franch, has multiple bioactivities, such as hypoglycemic, antimicrobial, and antioxidant activities. It is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.


Amfebutamone (Bupropion) HCl

Amfebutamone (Bupropion) HCl is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively.


Galanthamine HBr

Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase.


Aclidinium Bromide

Aclidinium Bromide inhibits human muscarinic AChR M1, M2, M3, M4 and M5 with Ki of 0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM and 0.16 nM, respectively.


Rocuronium Bromide

Rocuronium Bromide is a competitive AchR antagonist, used in modern anaesthesia.


Otilonium Bromide

Otilonium bromide is an antimuscarinic.


Gallamine Triethiodide

Gallamine Triethiodide is a cholinergic receptor blocker with an IC50 of 68.0 ± 8.4 μM.


Pyridostigmine Bromide

Pyridostigmine Bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.


Rivastigmine Tartrate

Rivastigmine Tartrate is a cholinesterase inhibitor with IC50 of 5.5 μM, and used as a parasympathomimetic or cholinergic agent for the treatment of mild to moderate Alzheimer disease.



Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.


Neostigmine Bromide

Neostigmine Bromide is a reversible acetylcholinesterase inhibitor.



Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 μM.



Hyoscyamine is an AChR inhibitor with IC50 of 7.5 nM.


Procaine HCl

Procaine is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM.


Dehydroevodiamine hydrochloride

Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.


Atracurium Besylate

Atracurium Besylate is a neuromuscular blocking agent with ED95 of 0.2 mg/kg.



Loganin is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. It is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively.


Itopride hydrochloride

Itopride hydrochloride is an AChE inhibitor. The IC50 of itopride with AChE is 2.04 +/- 0.27 μM.


Benzethonium Chloride

Benzethonium chloride is a potent inhibitor of nAChRs, it inhibits α4β2 nAChRs and α7 nAChRs with IC50 of 49 nM and 122 nM, respectively.


Tacrine hydrochloride hydrate

Tacrine is a centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. It also acts as a histamine N-methyltransferase inhibitor.


Pirenzepine dihydrochloride

Pirenzepine is an antimuscarinic agent which inhibits gastric acid secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular and urinary functions.



Palmatine, an isoquinoline alkaloid, has sedative, antidepressant, antioxidative, anti-ulcerative, antacid, anticancer, and anti-metastatic activities.


Vinblastine sulfate

Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.



Rivastigmine is a cholinesterase inhibitor with IC50 of 5.5 μM. It inhibits acetylcholinesterase (IC50 = 4.15 µM) and butyrylcholinesterase (IC50 = 37 nM).


Trihexyphenidyl hydrochloride

Trihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class.


Adiphenine HCl

Adiphenine HCl is a nicotinic receptor inhibitor with IC50 of 15 μM, used as an antispasmodic drug.


Pralidoxime Iodide

Pralidoxime Iodide (2-PAM) is an antidote approved for reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning.


Pralidoxime chloride

Pralidoxime is an antidote to organophosphate pesticides and chemicals; An acetylcholinesterase (AChE) reactivator.


Tiotropium Bromide hydrate

Tiotropium Bromide hydrate is a monohydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a muscarinic receptor antagonist.


Pancuronium dibromide

Pancuronium dibromide is a competitive nicotinic acetylcholine receptor antagonist, used as a muscle relaxant.


Tolterodine tartrate

Tolterodine tartrate is a tartrate salt of tolterodine that is a competitive muscarinic receptor antagonist.


Scopolamine N-Oxide HydrobroMide Monohydrate

Scopolamine N-Oxide is a muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.


Solifenacin (YM905)

Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.


Clidinium Bromide

Clidinium Bromide is an anticholinergic drug.



Tropisetron is a 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.



Revefenacin (TD-4208) is a potent, lung-selective, long-acting muscarinic antagonist that may be for the treatment of respiratory disease.



Nanofin is a ganglion blocker alkaloid having nicotinic acetylcholine receptor antagonist action. It has antihypertensive effect used for mild to moderate hypertension.


Propantheline bromide


Methylbenactyzine Bromide

Methylbenactyzine Bromide is a kind of muscarinic cholinergic receptor antagonist with antispasmodic activity.


Fesoterodine Fumarate

Fesoterodine Fumarate is a prodrug of 5-hydroxymethyl tolterodine that is a muscarinic AChR receptor antagonist, used to treat overactive bladder syndrome.



Oxybutynin is a competitive antagonist of the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor, used to relieve urinary and bladder difficulties.


Solifenacin succinate

Solifenacin succinate is a urinary antispasmodic of the antimuscarinic class.


Ipratropium Bromide

Ipratropium Bromide is an antagonist of M3 type muscarinic acetylcholine receptors, used for the treatment of chronic obstructive pulmonary disease (COPD).


Trospium chloride

Trospium chloride is a competitive muscarinic cholinergic receptor antagonist.


Atropine sulfate monohydrate

Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.



Methscopolamine is a muscarinic acetylcholine receptor blocker.


Scopolamine HBr

Scopolamine HBr is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 nM.


5-hydroxymethyl Tolterodine (PNU 200577, 5-HMT, 5-HM)

5-hydroxymethyl tolterodine (PNU 200577) is a new muscarinic receptor antagonist with Kb of 0.84 nM.


Darifenacin HBr

Darifenacin is a selective M3 muscarinic receptor antagonist with pKi of 8.9.


Homatropine Methylbromide

Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.


Homatropine Bromide

Homatropine Bromide is an muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.


Flavoxate HCl

Flavoxate is a muscarinic AChR antagonist with IC50 of 12.2 μM.


Orphenadrine Citrate

Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.


Diphemanil Methylsulfate

Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).


Pentoxyverine Citrate

Pentoxyverine Citrate is an antitussive (cough suppressant) commonly used for cough associated with illnesses like common cold.


Benactyzine hydrochloride

Benactyzine hydrochloride is a centrally acting muscarinic antagonist. It is used as an antidepressant in the treatment of depression and associated anxiety.


Hexamethonium Dibromide

Hexamethonium Dibromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia.



Glycopyrrolate is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.


Umeclidinium bromide

Umeclidinium bromide is a long-acting muscarinic antagonist approved for the maintenance treatment of chronic obstructive pulmonary disease (COPD).


Oxybutynin hydrochloride

Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.


Diphenidol HCl

Diphenidol HCl is a potent antagonist of muscarinic M2 and M3 receptor with pKb of 6.72 and 7.02, respectively, used in the treatment of vomiting and vertigo.



Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM.


PNU 282987

PNU 282987 is a potent agonist of α7-containing neuronal nicotinic acetylcholine receptors with Ki value of 26 nM for the rat receptor.


Acetylcholine Chloride

The chemical compound Acetylcholine Chloride is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans.


Varenicline Tartrate

Varenicline Tartrate is a nicotinic AChR partial agonist, used to treat nicotine addiction.


Bethanechol chloride

Bethanechol chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors.


Arecoline HBr

Arecoline is a muscarinic acetylcholine receptor agonist.


Pilocarpine HCl

Pilocarpine HCl is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.


Succinylcholine Chloride Dihydrate

Succinylcholine Chloride Dihydrate is a nicotinic AChR agonist and also acts as a depolarizing neuromuscular blocker.



Nitenpyram is a nicotinic acetylcholine receptor (AchR) agonist, used as veterinary medicine to treat parasites of livestock and pets.



LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.



Cytisine is a nicotinic acetylcholine receptor agonist.


Choline Chloride

Choline chloride is a quaternary ammonium salt used as an additive for animal feed. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.


Decamethonium Bromide

Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.


Methacholine chloride

Methacholine is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system but has little effects on the nicotinic receptors.


Acetylcholine iodide

Acetylcholine iodide is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.



BQCA is a highly selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR).


Morantel tartrate

Morantel is a positive allosteric modulator of neuronal nicotinic acetylcholine receptors (nAChRs).


Lobeline hydrochloride

Lobeline hydrochloride is an alkaloid that acts on nicotinic cholinergic receptors but is less potent than nicotine. It is also a VMAT2 ligand and an antagonist of μ-opioid receptors.



PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.


Vecuronium Bromide

Vecuronium is a non-depolarizing neuromuscular blocking agent, used for skeletal muscle relaxation during surgery.


Dextromethorphan hydrobromide hydrate

Dextromethorphan is an antitussive (cough suppressant) drug of the morphinan class with sedative, dissociative, and stimulant properties (at higher doses).