AChR

Signaling Pathway Map

Research Area

Inhibitory Selectivity
Solubility

Catalog No.	Product Name	Solubility(25°C)
Catalog No.	Product Name	Water	DMSO	Alcohol
S2462	Donepezil HCl	5 mg/mL	<1 mg/mL	<1 mg/mL
S2251	(-)-Huperzine A (HupA)	<1 mg/mL	0.66 mg/mL	<1 mg/mL
S5493	Atropine sulfate	-1 mg/mL	18 mg/mL	-1 mg/mL
S5511	Ethyl (triphenylphosphoranylidene) acetate	-1 mg/mL	69 mg/mL	-1 mg/mL
S5073	Donepezil	-1 mg/mL	75 mg/mL	-1 mg/mL
S5075	Acotiamide	<1 mg/mL	90 mg/mL	38 mg/mL
S4838	Acotiamide hydrochloride	5 mg/mL	100 mg/mL	20 mg/mL
S4776	Harmaline	-1 mg/mL	23 mg/mL	-1 mg/mL
S3866	Galanthamine	57 mg/mL	100 mg/mL	-1 mg/mL
S3903	Lycorine	-1 mg/mL	57 mg/mL	-1 mg/mL
S3884	Jatrorrhizine	-1 mg/mL	67 mg/mL	-1 mg/mL
S3769	Palmatine	-1 mg/mL	70 mg/mL	-1 mg/mL
S3820	Dehydroevodiamine hydrochloride	-1 mg/mL	37 mg/mL	-1 mg/mL
S3835	Loganin	-1 mg/mL	78 mg/mL	-1 mg/mL
S3639	Tacrine hydrochloride hydrate	50 mg/mL	50 mg/mL	50 mg/mL
S3662	Pirenzepine dihydrochloride	84 mg/mL	1 mg/mL	<1 mg/mL
S2452	Amfebutamone (Bupropion) HCl	<1 mg/mL	8 mg/mL	<1 mg/mL
S1339	Galanthamine HBr	36 mg/mL	<1 mg/mL	<1 mg/mL
S4031	Aclidinium Bromide	<1 mg/mL	113 mg/mL	<1 mg/mL
S1397	Rocuronium Bromide	122 mg/mL	122 mg/mL	122 mg/mL
S3047	Otilonium Bromide	113 mg/mL	113 mg/mL	113 mg/mL
S2471	Gallamine Triethiodide	100 mg/mL	100 mg/mL	<1 mg/mL
S1608	Pyridostigmine Bromide	52 mg/mL	52 mg/mL	52 mg/mL
S2087	Rivastigmine Tartrate	80 mg/mL	42 mg/mL	80 mg/mL
S1929	Irsogladine	<1 mg/mL	2 mg/mL	<1 mg/mL
S2490	Neostigmine Bromide	60 mg/mL	<1 mg/mL	<1 mg/mL
S3202	Catharanthine	<1 mg/mL	67 mg/mL	3 mg/mL
S4014	Hyoscyamine	<1 mg/mL	58 mg/mL	58 mg/mL
S4023	Procaine HCl	55 mg/mL	55 mg/mL	<1 mg/mL
S1832	Atracurium Besylate	33 mg/mL	100 mg/mL	100 mg/mL
S4619	Itopride hydrochloride	78 mg/mL	78 mg/mL	38 mg/mL
S4162	Benzethonium Chloride	90 mg/mL	90 mg/mL	90 mg/mL
S4505	Vinblastine sulfate	<1 mg/mL	100 mg/mL	<1 mg/mL
S4542	Trihexyphenidyl hydrochloride	<1 mg/mL	7 mg/mL	24 mg/mL
S2082	Adiphenine HCl	70 mg/mL	30 mg/mL	18 mg/mL
S5100	Pralidoxime Iodide	-1 mg/mL	52 mg/mL	-1 mg/mL
S4575	Pralidoxime chloride	34 mg/mL	<1 mg/mL	1 mg/mL
S2547	Tiotropium Bromide hydrate	<1 mg/mL	8 mg/mL	<1 mg/mL
S2497	Pancuronium dibromide	100 mg/mL	100 mg/mL	100 mg/mL
S2550	Tolterodine tartrate	17 mg/mL	95 mg/mL	6 mg/mL
S5238	Solifenacin (YM905)	-1 mg/mL	72 mg/mL	-1 mg/mL
S5538	Tropisetron	56 mg/mL	10 mg/mL	-1 mg/mL
S5480	Clidinium Bromide	-1 mg/mL	86 mg/mL	-1 mg/mL
S5258	Revefenacin	<1 mg/mL	100 mg/mL	100 mg/mL
S4834	Propantheline bromide	-1 mg/mL	89 mg/mL	-1 mg/mL
S4623	Methylbenactyzine Bromide	84 mg/mL	84 mg/mL	84 mg/mL
S3735	Umeclidinium bromide	<1 mg/mL	100 mg/mL	12 mg/mL
S3701	Benactyzine hydrochloride	72 mg/mL	72 mg/mL	72 mg/mL
S2240	Fesoterodine Fumarate	100 mg/mL	100 mg/mL	100 mg/mL
S1754	Oxybutynin	<1 mg/mL	71 mg/mL	71 mg/mL
S3048	Solifenacin succinate	96 mg/mL	3 mg/mL	5 mg/mL
S1683	Ipratropium Bromide	83 mg/mL	83 mg/mL	83 mg/mL
S2549	Trospium chloride	86 mg/mL	41 mg/mL	42 mg/mL
S2130	Atropine sulfate monohydrate	139 mg/mL	139 mg/mL	139 mg/mL
S1978	Methscopolamine	67 mg/mL	79 mg/mL	<1 mg/mL
S2508	Scopolamine HBr	76 mg/mL	76 mg/mL	<1 mg/mL
S2659	5-hydroxymethyl Tolterodine (PNU 200577, 5-HMT, 5-HM)	<1 mg/mL	68 mg/mL	68 mg/mL
S3144	Darifenacin HBr	<1 mg/mL	100 mg/mL	<1 mg/mL
S4024	Homatropine Methylbromide	74 mg/mL	74 mg/mL	10 mg/mL
S4025	Homatropine Bromide	71 mg/mL	71 mg/mL	<1 mg/mL
S4027	Flavoxate HCl	10 mg/mL	3 mg/mL	<1 mg/mL
S2054	Orphenadrine Citrate	<1 mg/mL	92 mg/mL	<1 mg/mL
S4034	Diphemanil Methylsulfate	28 mg/mL	25 mg/mL	<1 mg/mL
S4143	Pentoxyverine Citrate	100 mg/mL	100 mg/mL	8 mg/mL
S4069	Hexamethonium Dibromide	73 mg/mL	<1 mg/mL	<1 mg/mL
S4660	Glycopyrrolate	79 mg/mL	65 mg/mL	59 mg/mL
S3117	Oxybutynin hydrochloride	4 mg/mL	79 mg/mL	79 mg/mL
S4292	Diphenidol HCl	13 mg/mL	69 mg/mL	36 mg/mL
S1913	Tropicamide	<1 mg/mL	57 mg/mL	57 mg/mL
S1805	Acetylcholine Chloride	36 mg/mL	36 mg/mL	36 mg/mL
S3684	Methacholine chloride	39 mg/mL	39 mg/mL	39 mg/mL
S1440	Varenicline Tartrate	72 mg/mL	1 mg/mL	<1 mg/mL
S2455	Bethanechol chloride	39 mg/mL	39 mg/mL	39 mg/mL
S2614	Arecoline HBr	47 mg/mL	47 mg/mL	10 mg/mL
S4231	Pilocarpine HCl	48 mg/mL	48 mg/mL	48 mg/mL
S4121	Succinylcholine Chloride Dihydrate	79 mg/mL	1 mg/mL	<1 mg/mL
S4422	Nitenpyram	54 mg/mL	54 mg/mL	54 mg/mL
S7366	LY2119620	<1 mg/mL	87 mg/mL	10 mg/mL
S2287	Cytisine	38 mg/mL	38 mg/mL	38 mg/mL
S4171	Choline Chloride	28 mg/mL	28 mg/mL	28 mg/mL
S4072	Decamethonium Bromide	84 mg/mL	34 mg/mL	25 mg/mL
S4718	Acetylcholine iodide	54 mg/mL	54 mg/mL	54 mg/mL
S2462	Donepezil HCl	5 mg/mL	<1 mg/mL	<1 mg/mL
S2251	(-)-Huperzine A (HupA)	<1 mg/mL	0.66 mg/mL	<1 mg/mL
S5493	Atropine sulfate	-1 mg/mL	18 mg/mL	-1 mg/mL
S5511	Ethyl (triphenylphosphoranylidene) acetate	-1 mg/mL	69 mg/mL	-1 mg/mL
S5073	Donepezil	-1 mg/mL	75 mg/mL	-1 mg/mL
S5075	Acotiamide	<1 mg/mL	90 mg/mL	38 mg/mL
S4838	Acotiamide hydrochloride	5 mg/mL	100 mg/mL	20 mg/mL
S4776	Harmaline	-1 mg/mL	23 mg/mL	-1 mg/mL
S3866	Galanthamine	57 mg/mL	100 mg/mL	-1 mg/mL
S3903	Lycorine	-1 mg/mL	57 mg/mL	-1 mg/mL
S3884	Jatrorrhizine	-1 mg/mL	67 mg/mL	-1 mg/mL
S3769	Palmatine	-1 mg/mL	70 mg/mL	-1 mg/mL
S3820	Dehydroevodiamine hydrochloride	-1 mg/mL	37 mg/mL	-1 mg/mL
S3835	Loganin	-1 mg/mL	78 mg/mL	-1 mg/mL
S3639	Tacrine hydrochloride hydrate	50 mg/mL	50 mg/mL	50 mg/mL
S3662	Pirenzepine dihydrochloride	84 mg/mL	1 mg/mL	<1 mg/mL
S2452	Amfebutamone (Bupropion) HCl	<1 mg/mL	8 mg/mL	<1 mg/mL
S1339	Galanthamine HBr	36 mg/mL	<1 mg/mL	<1 mg/mL
S4031	Aclidinium Bromide	<1 mg/mL	113 mg/mL	<1 mg/mL
S1397	Rocuronium Bromide	122 mg/mL	122 mg/mL	122 mg/mL
S3047	Otilonium Bromide	113 mg/mL	113 mg/mL	113 mg/mL
S2471	Gallamine Triethiodide	100 mg/mL	100 mg/mL	<1 mg/mL
S1608	Pyridostigmine Bromide	52 mg/mL	52 mg/mL	52 mg/mL
S2087	Rivastigmine Tartrate	80 mg/mL	42 mg/mL	80 mg/mL
S1929	Irsogladine	<1 mg/mL	2 mg/mL	<1 mg/mL
S2490	Neostigmine Bromide	60 mg/mL	<1 mg/mL	<1 mg/mL
S3202	Catharanthine	<1 mg/mL	67 mg/mL	3 mg/mL
S4014	Hyoscyamine	<1 mg/mL	58 mg/mL	58 mg/mL
S4023	Procaine HCl	55 mg/mL	55 mg/mL	<1 mg/mL
S1832	Atracurium Besylate	33 mg/mL	100 mg/mL	100 mg/mL
S4619	Itopride hydrochloride	78 mg/mL	78 mg/mL	38 mg/mL
S4162	Benzethonium Chloride	90 mg/mL	90 mg/mL	90 mg/mL
S4505	Vinblastine sulfate	<1 mg/mL	100 mg/mL	<1 mg/mL
S4542	Trihexyphenidyl hydrochloride	<1 mg/mL	7 mg/mL	24 mg/mL
S2082	Adiphenine HCl	70 mg/mL	30 mg/mL	18 mg/mL
S1405	Vecuronium Bromide	4 mg/mL	100 mg/mL	100 mg/mL
S4617	Dextromethorphan hydrobromide hydrate	<1 mg/mL	74 mg/mL	74 mg/mL

Isoform-specific Inhibitors

AChR Inhibitors (122)
New AChR Products

Catalog No.	Information	Product Use Citations	Product Validations
S2462	Donepezil HCl Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.	J Am Heart Assoc, 2014, 3(3):e000804	Donepezil-mediated eACh activity in vitro. After being cultured in serum-free EBM-2, HUVECs were treated with donepezil at a concentration of 10 umol/L for 24 hours. E and F: Representative images (x 400 magnification) of anti-ChAT and -VAChT immunofluorescence. Scale bar: 50 um. ChAT indicates choline acetyltransferase; eACh, endothelium-derived acetylcholine; EBM-2, endothelial basal medium 2; HUVECs, human umbilical vein endothelial cells; PCR, polymerase chain reaction; VAChT, vesicular acetylcholine transporter.
S2251	(-)-Huperzine A (HupA) (-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with K_i of 7 nM, exhibiting 200-fold more selectivity for G4 AChE over G1 AChE. Also acts as an NMDA receptor antagonist. Phase 4.
S5493^New	Atropine sulfate Atropine Sulfate is the sulfate salt of atropine, which is a natural alkaloid anticholinergic agent and has potent antimuscarinic effects.
S5511^New	Ethyl (triphenylphosphoranylidene) acetate Ethyl (triphenylphosphoranylidene) acetate may act as an inhibitor of cholinesterase that inhibits AChE and BChE.
S5073^New	Donepezil Donepezil is a piperidine based, potent, specific, non-competitive and reversible inhibitor of acetylcholinesterase (AChE) used for the treatment of mild to moderate dementia of the Alzheimer's type.
S5075^New	Acotiamide Acotiamide is a novel acetylcholinesterase inhibitor with fundus-relaxing and gastroprokinetic properties.
S4838^New	Acotiamide hydrochloride Acotiamide Hydrochloride is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. It is a new orally active selective acetylcholinesterase inhibitor.
S4776^New	Harmaline Harmaline, a natural occurrence β-carboline alkaloid, is a central nervous system stimulant and an acetylcholinesterase (AChR) inhibitor; also inhibits histamine N-methyltransferase.
S3866^New	Galanthamine Galantamine is a phenanthrene alkaloid and a reversible, competitive acetylcholinesterase inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase. It is studied as a treatment for Alzheimer's disease and other central nervous system disorders.
S3903^New	Lycorine Lycorine is a toxic crystalline alkaloid found in various Amaryllidaceae species that weakly inhibits acetylcholinesterase (AChE) and ascorbic acid biosynthesis.
S3884^New	Jatrorrhizine Jatrorrhizine, one of the active constituents of Coptis chinensis Franch, has multiple bioactivities, such as hypoglycemic, antimicrobial, and antioxidant activities. It is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.
S3769^New	Palmatine Palmatine, an isoquinoline alkaloid, has sedative, antidepressant, antioxidative, anti-ulcerative, antacid, anticancer, and anti-metastatic activities.
S3820^New	Dehydroevodiamine hydrochloride Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.
S3835^New	Loganin Loganin is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. It is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively.
S3639^New	Tacrine hydrochloride hydrate Tacrine is a centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. It also acts as a histamine N-methyltransferase inhibitor.
S3662^New	Pirenzepine dihydrochloride Pirenzepine is an antimuscarinic agent which inhibits gastric acid secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular and urinary functions.
S2452	Amfebutamone (Bupropion) HCl Amfebutamone (Bupropion) HCl is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively.	G3 (Bethesda), 2014, 4(6):1081-9 Georgia State University, 2014, Chaquettea Felton G3 (Bethesda), 2014, 10.1534/g3.114.010819
S1339	Galanthamine HBr Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase.
S4031	Aclidinium Bromide Aclidinium Bromide inhibits human muscarinic AChR M1, M2, M3, M4 and M5 with K_i of 0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM and 0.16 nM, respectively.
S1397	Rocuronium Bromide Rocuronium Bromide is a competitive AchR antagonist, used in modern anaesthesia.
S3047	Otilonium Bromide Otilonium bromide is an antimuscarinic.
S2471	Gallamine Triethiodide Gallamine Triethiodide is a cholinergic receptor blocker with an IC50 of 68.0 ± 8.4 μM.
S1608	Pyridostigmine Bromide Pyridostigmine Bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.	J Am Heart Assoc, 2014, 3(3):e000804	Acetylcholine (ACh)-related protein expression in vivo. Choline acetyltransferase (ChAT) in the ischemic area were determined among 3 experimental groups. Data of Western blotting are represented as fold of control.
S2087	Rivastigmine Tartrate Rivastigmine Tartrate is a cholinesterase inhibitor with IC50 of 5.5 μM, and used as a parasympathomimetic or cholinergic agent for the treatment of mild to moderate Alzheimer disease.
S1929	Irsogladine Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.
S2490	Neostigmine Bromide Neostigmine Bromide is a reversible acetylcholinesterase inhibitor.
S3202	Catharanthine Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 μM.
S4014	Hyoscyamine Hyoscyamine is an AChR inhibitor with IC50 of 7.5 nM.
S4023	Procaine HCl Procaine is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with K_D of 1.7 μM.	Biomol Ther (Seoul), 2016, 24(5):489-94 Biomol Ther (Seoul), 2016, 24(5):489-94	Procaine pretreatment inhibits JAK2 and STAT3 expression. (A) Relative Jak2 mRNA level detected by qRT-PCR. (B) Relative Stat3 mRNA level detected by qRT-PCR. (C) JAK2 and STAT3 protein expression detected by western blot. (D) Relative protein levels of JAK2 and STAT3 based on Western blot results. sham, rats undergone sham surgery. CCI, rats undergone sciatic nerve chronic compression injury (CCI) as the neuropathic pain (NPP) model. CCI+procaine, NPP model rats pretreated with procaine. The detection is performed on the 20th day post surgery (n=3). GAPDH is used as an internal reference. p<0.05, *p<0.01. JAK2, Janus kinase 2. STAT3, signal transducer and activator of transcription 3.
S1832	Atracurium Besylate Atracurium Besylate is a neuromuscular blocking agent with ED95 of 0.2 mg/kg.
S4619	Itopride hydrochloride Itopride hydrochloride is an AChE inhibitor. The IC50 of itopride with AChE is 2.04 +/- 0.27 μM.
S4162	Benzethonium Chloride Benzethonium chloride is a potent inhibitor of nAChRs, it inhibits α4β2 nAChRs and α7 nAChRs with IC50 of 49 nM and 122 nM, respectively.
S4505	Vinblastine sulfate Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.
S4687	Rivastigmine Rivastigmine is a cholinesterase inhibitor with IC50 of 5.5 μM. It inhibits acetylcholinesterase (IC50 = 4.15 µM) and butyrylcholinesterase (IC50 = 37 nM).	Nature, 2018, 560(7718):372-376
S4542	Trihexyphenidyl hydrochloride Trihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class.
S2082	Adiphenine HCl Adiphenine HCl is a nicotinic receptor inhibitor with IC50 of 15 μM, used as an antispasmodic drug.
S5100^New	Pralidoxime Iodide Pralidoxime Iodide (2-PAM) is an antidote approved for reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning.
S4575	Pralidoxime chloride Pralidoxime is an antidote to organophosphate pesticides and chemicals; An acetylcholinesterase (AChE) reactivator.
S2547	Tiotropium Bromide hydrate Tiotropium Bromide hydrate is a monohydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a muscarinic receptor antagonist.
S2497	Pancuronium dibromide Pancuronium dibromide is a competitive nicotinic acetylcholine receptor antagonist, used as a muscle relaxant.	J Vis Exp, 2014, (84):e51271
S2550	Tolterodine tartrate Tolterodine tartrate is a tartrate salt of tolterodine that is a competitive muscarinic receptor antagonist.
S5238^New	Solifenacin (YM905) Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.
S5538^New	Tropisetron Tropisetron is a 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.
S5480^New	Clidinium Bromide Clidinium Bromide is an anticholinergic drug.
S5258^New	Revefenacin Revefenacin (TD-4208) is a potent, lung-selective, long-acting muscarinic antagonist that may be for the treatment of respiratory disease.
S4992^New	Nanofin Nanofin is a ganglion blocker alkaloid having nicotinic acetylcholine receptor antagonist action. It has antihypertensive effect used for mild to moderate hypertension.
S4834^New	Propantheline bromide
S4623^New	Methylbenactyzine Bromide Methylbenactyzine Bromide is a kind of muscarinic cholinergic receptor antagonist with antispasmodic activity.
S3735^New	Umeclidinium bromide Umeclidinium bromide is a long-acting muscarinic antagonist approved for the maintenance treatment of chronic obstructive pulmonary disease (COPD).
S3701^New	Benactyzine hydrochloride Benactyzine hydrochloride is a centrally acting muscarinic antagonist. It is used as an antidepressant in the treatment of depression and associated anxiety.
S2240	Fesoterodine Fumarate Fesoterodine Fumarate is a prodrug of 5-hydroxymethyl tolterodine that is a muscarinic AChR receptor antagonist, used to treat overactive bladder syndrome.
S1754	Oxybutynin Oxybutynin is a competitive antagonist of the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor, used to relieve urinary and bladder difficulties.
S3048	Solifenacin succinate Solifenacin succinate is a urinary antispasmodic of the antimuscarinic class.
S1683	Ipratropium Bromide Ipratropium Bromide is an antagonist of M3 type muscarinic acetylcholine receptors, used for the treatment of chronic obstructive pulmonary disease (COPD).
S2549	Trospium chloride Trospium chloride is a competitive muscarinic cholinergic receptor antagonist.
S2130	Atropine sulfate monohydrate Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.
S1978	Methscopolamine Methscopolamine is a muscarinic acetylcholine receptor blocker.
S2508	Scopolamine HBr Scopolamine HBr is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 nM.	Nature, 2018, 560(7718):372-376
S2659	5-hydroxymethyl Tolterodine (PNU 200577, 5-HMT, 5-HM) 5-hydroxymethyl tolterodine (PNU 200577) is a new muscarinic receptor antagonist with K_b of 0.84 nM.
S3144	Darifenacin HBr Darifenacin is a selective M3 muscarinic receptor antagonist with pK_i of 8.9.
S4024	Homatropine Methylbromide Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.	Nature, 2018, 560(7718):372-376
S4025	Homatropine Bromide Homatropine Bromide is an muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.
S4027	Flavoxate HCl Flavoxate is a muscarinic AChR antagonist with IC50 of 12.2 μM.
S2054	Orphenadrine Citrate Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.
S4034	Diphemanil Methylsulfate Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).
S4143	Pentoxyverine Citrate Pentoxyverine Citrate is an antitussive (cough suppressant) commonly used for cough associated with illnesses like common cold.
S4069	Hexamethonium Dibromide Hexamethonium Dibromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia.
S4660	Glycopyrrolate Glycopyrrolate is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.
S3117	Oxybutynin hydrochloride Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.
S4292	Diphenidol HCl Diphenidol HCl is a potent antagonist of muscarinic M2 and M3 receptor with pK_b of 6.72 and 7.02, respectively, used in the treatment of vomiting and vertigo.
S1913	Tropicamide Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM.
S1805^New	Acetylcholine Chloride The chemical compound Acetylcholine Chloride is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans.
S3684^New	Methacholine chloride Methacholine is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system but has little effects on the nicotinic receptors.
S1440	Varenicline Tartrate Varenicline Tartrate is a nicotinic AChR partial agonist, used to treat nicotine addiction.
S2455	Bethanechol chloride Bethanechol chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors.
S2614	Arecoline HBr Arecoline is a muscarinic acetylcholine receptor agonist.	Oncol Rep, 2015, 33(6):2753-60	Arecoline affects expression of epithelial-mesenchymal transition-related genes in a dose-dependent manner. Expression of epithelial-mesenchymal transition-related genes (CK19, E-cadherin, N-cadherin and vimentin) in HaCaT cells was determined by western blotting and the results were quantified. Data shown are means ± SD, P<0.05, P<0.01, **P<0.001. CK19, cytokeratin 19.
S4231	Pilocarpine HCl Pilocarpine HCl is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.
S4121	Succinylcholine Chloride Dihydrate Succinylcholine Chloride Dihydrate is a nicotinic AChR agonist and also acts as a depolarizing neuromuscular blocker.
S4422	Nitenpyram Nitenpyram is a nicotinic acetylcholine receptor (AchR) agonist, used as veterinary medicine to treat parasites of livestock and pets.
S7366	LY2119620 LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.
S2287	Cytisine Cytisine is a nicotinic acetylcholine receptor agonist.
S4171	Choline Chloride Choline chloride is a quaternary ammonium salt used as an additive for animal feed. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
S4072	Decamethonium Bromide Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.
S4718	Acetylcholine iodide Acetylcholine iodide is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
S2462	Donepezil HCl Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.	J Am Heart Assoc, 2014, 3(3):e000804	Donepezil-mediated eACh activity in vitro. After being cultured in serum-free EBM-2, HUVECs were treated with donepezil at a concentration of 10 umol/L for 24 hours. E and F: Representative images (x 400 magnification) of anti-ChAT and -VAChT immunofluorescence. Scale bar: 50 um. ChAT indicates choline acetyltransferase; eACh, endothelium-derived acetylcholine; EBM-2, endothelial basal medium 2; HUVECs, human umbilical vein endothelial cells; PCR, polymerase chain reaction; VAChT, vesicular acetylcholine transporter.
S2251	(-)-Huperzine A (HupA) (-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with K_i of 7 nM, exhibiting 200-fold more selectivity for G4 AChE over G1 AChE. Also acts as an NMDA receptor antagonist. Phase 4.
S5493^New	Atropine sulfate Atropine Sulfate is the sulfate salt of atropine, which is a natural alkaloid anticholinergic agent and has potent antimuscarinic effects.
S5511^New	Ethyl (triphenylphosphoranylidene) acetate Ethyl (triphenylphosphoranylidene) acetate may act as an inhibitor of cholinesterase that inhibits AChE and BChE.
S5073^New	Donepezil Donepezil is a piperidine based, potent, specific, non-competitive and reversible inhibitor of acetylcholinesterase (AChE) used for the treatment of mild to moderate dementia of the Alzheimer's type.
S5075^New	Acotiamide Acotiamide is a novel acetylcholinesterase inhibitor with fundus-relaxing and gastroprokinetic properties.
S4838^New	Acotiamide hydrochloride Acotiamide Hydrochloride is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. It is a new orally active selective acetylcholinesterase inhibitor.
S4776^New	Harmaline Harmaline, a natural occurrence β-carboline alkaloid, is a central nervous system stimulant and an acetylcholinesterase (AChR) inhibitor; also inhibits histamine N-methyltransferase.
S3866^New	Galanthamine Galantamine is a phenanthrene alkaloid and a reversible, competitive acetylcholinesterase inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase. It is studied as a treatment for Alzheimer's disease and other central nervous system disorders.
S3903^New	Lycorine Lycorine is a toxic crystalline alkaloid found in various Amaryllidaceae species that weakly inhibits acetylcholinesterase (AChE) and ascorbic acid biosynthesis.
S3884^New	Jatrorrhizine Jatrorrhizine, one of the active constituents of Coptis chinensis Franch, has multiple bioactivities, such as hypoglycemic, antimicrobial, and antioxidant activities. It is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.
S3769^New	Palmatine Palmatine, an isoquinoline alkaloid, has sedative, antidepressant, antioxidative, anti-ulcerative, antacid, anticancer, and anti-metastatic activities.
S3820^New	Dehydroevodiamine hydrochloride Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.
S3835^New	Loganin Loganin is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. It is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively.
S3639^New	Tacrine hydrochloride hydrate Tacrine is a centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. It also acts as a histamine N-methyltransferase inhibitor.
S3662^New	Pirenzepine dihydrochloride Pirenzepine is an antimuscarinic agent which inhibits gastric acid secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular and urinary functions.
S2452	Amfebutamone (Bupropion) HCl Amfebutamone (Bupropion) HCl is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively.	G3 (Bethesda), 2014, 4(6):1081-9 Georgia State University, 2014, Chaquettea Felton G3 (Bethesda), 2014, 10.1534/g3.114.010819
S1339	Galanthamine HBr Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase.
S4031	Aclidinium Bromide Aclidinium Bromide inhibits human muscarinic AChR M1, M2, M3, M4 and M5 with K_i of 0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM and 0.16 nM, respectively.
S1397	Rocuronium Bromide Rocuronium Bromide is a competitive AchR antagonist, used in modern anaesthesia.
S3047	Otilonium Bromide Otilonium bromide is an antimuscarinic.
S2471	Gallamine Triethiodide Gallamine Triethiodide is a cholinergic receptor blocker with an IC50 of 68.0 ± 8.4 μM.
S1608	Pyridostigmine Bromide Pyridostigmine Bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.	J Am Heart Assoc, 2014, 3(3):e000804	Acetylcholine (ACh)-related protein expression in vivo. Choline acetyltransferase (ChAT) in the ischemic area were determined among 3 experimental groups. Data of Western blotting are represented as fold of control.
S2087	Rivastigmine Tartrate Rivastigmine Tartrate is a cholinesterase inhibitor with IC50 of 5.5 μM, and used as a parasympathomimetic or cholinergic agent for the treatment of mild to moderate Alzheimer disease.
S1929	Irsogladine Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.
S2490	Neostigmine Bromide Neostigmine Bromide is a reversible acetylcholinesterase inhibitor.
S3202	Catharanthine Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 μM.
S4014	Hyoscyamine Hyoscyamine is an AChR inhibitor with IC50 of 7.5 nM.
S4023	Procaine HCl Procaine is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with K_D of 1.7 μM.	Biomol Ther (Seoul), 2016, 24(5):489-94 Biomol Ther (Seoul), 2016, 24(5):489-94	Procaine pretreatment inhibits JAK2 and STAT3 expression. (A) Relative Jak2 mRNA level detected by qRT-PCR. (B) Relative Stat3 mRNA level detected by qRT-PCR. (C) JAK2 and STAT3 protein expression detected by western blot. (D) Relative protein levels of JAK2 and STAT3 based on Western blot results. sham, rats undergone sham surgery. CCI, rats undergone sciatic nerve chronic compression injury (CCI) as the neuropathic pain (NPP) model. CCI+procaine, NPP model rats pretreated with procaine. The detection is performed on the 20th day post surgery (n=3). GAPDH is used as an internal reference. p<0.05, *p<0.01. JAK2, Janus kinase 2. STAT3, signal transducer and activator of transcription 3.
S1832	Atracurium Besylate Atracurium Besylate is a neuromuscular blocking agent with ED95 of 0.2 mg/kg.
S4619	Itopride hydrochloride Itopride hydrochloride is an AChE inhibitor. The IC50 of itopride with AChE is 2.04 +/- 0.27 μM.
S4162	Benzethonium Chloride Benzethonium chloride is a potent inhibitor of nAChRs, it inhibits α4β2 nAChRs and α7 nAChRs with IC50 of 49 nM and 122 nM, respectively.
S4505	Vinblastine sulfate Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.
S4687	Rivastigmine Rivastigmine is a cholinesterase inhibitor with IC50 of 5.5 μM. It inhibits acetylcholinesterase (IC50 = 4.15 µM) and butyrylcholinesterase (IC50 = 37 nM).	Nature, 2018, 560(7718):372-376
S4542	Trihexyphenidyl hydrochloride Trihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class.
S2082	Adiphenine HCl Adiphenine HCl is a nicotinic receptor inhibitor with IC50 of 15 μM, used as an antispasmodic drug.
S1405	Vecuronium Bromide Vecuronium is a non-depolarizing neuromuscular blocking agent, used for skeletal muscle relaxation during surgery.
S4617	Dextromethorphan hydrobromide hydrate Dextromethorphan is an antitussive (cough suppressant) drug of the morphinan class with sedative, dissociative, and stimulant properties (at higher doses).

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