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AChR Agonists/Antagonist

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S6887 Clozapine N-oxide (CNO chemical) CNO (Clozapine N-oxide) is a metabolite of Clozapine (GLXC-06516) and an agonist of human muscarinic designer receptors (Designer Receptors Exclusively Activated by Designer Drugs, DREADDs). Clozapine is a potent dopamine (DA) antagonist and a selective muscarinic M4 receptor agonist.Solutions are unstable and should be fresh-prepared.
Molecular Medicine, November 23, 2025, nan
Frontiers in Aging Neuroscience, November 11, 2022, 1040569
Theranostics, 2025, 15(5):1822-1841
S2462 Donepezil HCl Donepezil HCl is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.This product is not soluble in PBS solution. Please do not dissolve it in PBS for administration.
Anticancer Research, September 2018, 5149-5157
Anticancer Research, September 15, 2018, 5149-5157
Journal of the American Heart Association, May 12, 2014, e000804
Verified customer review of Donepezil HCl
S2497 Pancuronium dibromide Pancuronium dibromide is a competitive nicotinic acetylcholine receptor antagonist, used as a muscle relaxant.
Biomedicines, November 28, 2022, 3056
eLife, March 22, 2019, e45399
Frontiers in Physiology, August 13, 2019, 1039
S2629 PNU-120596 PNU-120596 (Nsc 216666) is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.
PLoS One, August 9, 2013, e73581
British Journal of Pharmacology, August 2013, 1862-1878
Frontiers in Medicine, 2021, 642960
Verified customer review of PNU-120596
S2508 Scopolamine (LSM-4015) HBr Scopolamine HBr (LSM-4015,NSC 61806,(-)-Scopolamine hydrobromide, Hyoscine hydrobromide, Scopine hydrobromide) is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM.
Heliyon, 2024, 10(1):e23945
Heliyon, 2024, e23945
Zoological Research, 2023, 712-724
S4231 Pilocarpine HCl Pilocarpine HCl (NSC 5746) is a selective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.
Viruses, 2024, 16(10)1559
Heliyon, 2024, 10(1):e23945
Theranostics, 2021, 11(12):5986-6005
S5073 Donepezil Donepezil (Aricept, Donepezilo) is a piperidine based, potent, specific, non-competitive and reversible inhibitor of acetylcholinesterase (AChE) used for the treatment of mild to moderate dementia of the Alzheimer's type.
Anticancer Research, September 2018, 5149-5157
Anticancer Research, September 15, 2018, 5149-5157
Journal of the American Heart Association, May 2014, e000804
S1805 Acetylcholine Chloride The chemical compound Acetylcholine Chloride(ACh chloride) is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans.
Cell Mol Life Sci, 2024, 81(1):88
iScience, 2023, 26(3):106241
Cell, 2022, 185-21:3950-3965.e25
S1683 Ipratropium Bromide Ipratropium Bromide is an antagonist of M3 type muscarinic acetylcholine receptors, used for the treatment of chronic obstructive pulmonary disease (COPD).
bioRxiv, July 13, 2023, 2023.07.12.548707
Scientific Reports, February 19, 2026, 6980
bioRxiv, 2023, nan
S2614 Arecoline HBr Arecoline(NSC-31750) is a muscarinic acetylcholine receptor agonist.
BMC Molecular and Cell Biology, November 10, 2020, 80
Antioxidants (Basel), 2024, 13(4)430
Int J Oral Sci, 2024, 16(1):17
Verified customer review of Arecoline HBr

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