AChE Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S2251 (-)-Huperzine A (HupA)

(-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with Ki of 7 nM, exhibiting 200-fold more selectivity for G4 AChE over G1 AChE. Also acts as an NMDA receptor antagonist. Phase 4.

Selective AChE (G4 form), Ki: 7 nM
S2462 Donepezil HCl

Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.

Selective hAChE, IC50: 11.6 nM; bAChE, IC50: 8.12 nM
S1339 Galanthamine HBr

Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase.

Selective AChE, IC50: 0.35 μM