AChE Selective Inhibitors
|Catalog No.||Product Name||Information||Selective / Pan||IC50 / Ki|
|S2251||(-)-Huperzine A (HupA)||
(-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with Ki of 7 nM, exhibiting 200-fold more selectivity for G4 AChE over G1 AChE. Also acts as an NMDA receptor antagonist. Phase 4.
|Selective||AChE (G4 form), Ki: 7 nM|
Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.
|Selective||hAChE, IC50: 11.6 nM; bAChE, IC50: 8.12 nM|
Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase.
|Selective||AChE, IC50: 0.35 μM|
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