Diphenidol HCl

Catalog No.S4292

For research use only.

Diphenidol HCl is a potent antagonist of muscarinic M2 and M3 receptor with pKb of 6.72 and 7.02, respectively, used in the treatment of vomiting and vertigo.

Diphenidol HCl Chemical Structure

CAS No. 3254-89-5

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Biological Activity

Description Diphenidol HCl is a potent antagonist of muscarinic M2 and M3 receptor with pKb of 6.72 and 7.02, respectively, used in the treatment of vomiting and vertigo.
Targets
M2 mAChR [1] M2 mAChR [1] M3 mAChR [1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 69 mg/mL
(199.47 mM)
Ethanol 36 mg/mL warmed
(104.07 mM)
Water 13 mg/mL
(37.58 mM)

Chemical Information

Molecular Weight 345.91
Formula

C21H28ClNO

CAS No. 3254-89-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O.Cl

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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