Home Neuronal Signaling AChR agonist VU0357017 Hydrochloride

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VU0357017 Hydrochloride AChR agonist

Cat.No.S6795

VU0357017 hydrochloride (CID-25010775) is a potent, highly selective and CNS-penetrant agonist of M1 which is a subtype of muscarinic acetylcholine receptors (mAChRs). VU0357017 hydrochloride appears to act at an allosteric site to activate the receptor with EC50 of 477 nM and Ki of 9.91 μM.
VU0357017 Hydrochloride AChR agonist Chemical Structure

Chemical Structure

Molecular Weight: 369.89

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Quality Control

Batch: S679501 DMSO]38 mg/mL]false]Water]10 mg/mL]false]Ethanol]2 mg/mL]false Purity: 99.80%
99.80

Chemical Information, Storage & Stability

Molecular Weight 369.89 Formula

C18H28ClN3O3

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1135242-13-5 -- Storage of Stock Solutions

Synonyms CID-25010775 Smiles CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2C.Cl

Solubility

In vitro
Batch:

DMSO : 38 mg/mL (102.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 10 mg/mL

Ethanol : 2 mg/mL

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
M1 mAChR [1]
(Cell-free assay)
477 nM(EC50)
M1 mAChR [1]
(Cell-free assay)
9.91 μM(Ki)
References

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