Name: VU0357017 Hydrochloride
Brand: Selleck Chemicals
SKU: S6795
Rating: 5 (1 reviews)

VU0357017 hydrochloride (CID-25010775) is a potent, highly selective and CNS-penetrant agonist of M1 which is a subtype of muscarinic acetylcholine receptors (mAChRs). VU0357017 hydrochloride appears to act at an allosteric site to activate the receptor with EC50 of 477 nM and Ki of 9.91 μM.

VU0357017 Hydrochloride Chemical Structure

CAS: 1135242-13-5

Purity & Quality Control

Batch: S679501 DMSO] 38 mg/mL] false] Water] 10 mg/mL] false] Ethanol] 2 mg/mL] false Purity: 99.80%

99.80

VU0357017 Hydrochloride Related Products

Related Targets	mAChR nAChR AChE	Click to Expand
Related Products	Donepezil HCl PNU-120596 Pilocarpine HCl Pancuronium dibromide Scopolamine (LSM-4015) HBr Benzethonium Chloride CNO (Clozapine N-oxide) Donepezil Acetylcholine Chloride Amfebutamone (Bupropion) HCl Methscopolamine Arecoline HBr Bethanechol chloride Ipratropium Bromide Otilonium Bromide Choline Chloride Lycorine Darifenacin HBr Rivastigmine Tartrate Acetylcholine iodide Gallamine Triethiodide Hyoscyamine Neostigmine Bromide Atropine Homatropine Methylbromide Succinylcholine Chloride Dihydrate Edrophonium chloride (-)-Huperzine A (HupA) Nitenpyram Cytisine Glycopyrrolate Varenicline Tartrate (CP 526555-18) Trospium chloride Cevimeline HCl hemihydrate Rivastigmine Oxybutynin hydrochloride Chelidonine Galanthamine Atropine sulfate	Click to Expand
Related Compound Libraries	FDA-approved Drug Library Natural Product Library Neuronal Signaling Compound Library CNS-Penetrant Compound Library Anti-alzheimer Disease Compound Library	Click to Expand

Signaling Pathway

AChR Signaling Pathway

Choose Selective AChR Inhibitors

Biological Activity

Description

VU0357017 hydrochloride (CID-25010775) is a potent, highly selective and CNS-penetrant agonist of M1 which is a subtype of muscarinic acetylcholine receptors (mAChRs). VU0357017 hydrochloride appears to act at an allosteric site to activate the receptor with EC50 of 477 nM and Ki of 9.91 μM.

Targets

M1 mAChR ^[1] (Cell-free assay)	M1 mAChR ^[1] (Cell-free assay)
477 nM(EC50)	9.91 μM(Ki)

References

Chemical Information & Solubility

Molecular Weight	369.89	Formula	C₁₈H₂₈ClN₃O₃
CAS No.	1135242-13-5	SDF	--
Smiles	CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2C.Cl
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 38 mg/mL ( (102.73 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 10 mg/mL

Ethanol : 2 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):