VU0357017 Hydrochloride

Catalog No.S6795 Synonyms: CID-25010775

For research use only.

VU0357017 hydrochloride (CID-25010775) is a potent, highly selective and CNS-penetrant agonist of M1 which is a subtype of muscarinic acetylcholine receptors (mAChRs). VU0357017 hydrochloride appears to act at an allosteric site to activate the receptor with EC50 of 477 nM and Ki of 9.91 μM.

VU0357017 Hydrochloride Chemical Structure

CAS No. 1135242-13-5

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Biological Activity

Description VU0357017 hydrochloride (CID-25010775) is a potent, highly selective and CNS-penetrant agonist of M1 which is a subtype of muscarinic acetylcholine receptors (mAChRs). VU0357017 hydrochloride appears to act at an allosteric site to activate the receptor with EC50 of 477 nM and Ki of 9.91 μM.
Targets
M1 mAChR [1]
(Cell-free assay)
M1 mAChR [1]
(Cell-free assay)
477 nM(EC50) 9.91 μM(Ki)

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 369.89
Formula

C18H28ClN3O3

CAS No. 1135242-13-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2C.Cl

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