Home Neuronal Signaling AChR agonist Varenicline Hydrochloride For research use only.

Varenicline Hydrochloride

Synonyms: CP 526555 hydrochloride

Varenicline (CP 526555) Hydrochloride is a partial agonist of α4β2 nicotine acetylcholine receptor (nAChR) and α6β2 nicotine acetylcholine receptor (nAChR), with a Ki value of 0.12 nM and 0.14 nM for α6β2 nAChR and α4β2 nAChR, respectively, in the striatum of rats.

Varenicline Hydrochloride Chemical Structure

Varenicline Hydrochloride Chemical Structure

CAS: 230615-23-3

Purity & Quality Control

Batch: S502201 Water] 50 mg/mL] false] DMSO] Insoluble] false] Ethanol] Insoluble] false Purity: 99.95%
99.95

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Biological Activity

Description Varenicline (CP 526555) Hydrochloride is a partial agonist of α4β2 nicotine acetylcholine receptor (nAChR) and α6β2 nicotine acetylcholine receptor (nAChR), with a Ki value of 0.12 nM and 0.14 nM for α6β2 nAChR and α4β2 nAChR, respectively, in the striatum of rats.
Targets
α6β2 nAChR [1]
(Cell-free assay)		 α4β2 nAChR [1]
(Cell-free assay)
0.12 nM(Ki) 0.14 nM(Ki)

Chemical Information & Solubility

Molecular Weight 247.72 Formula

C13H14ClN3
CAS No. 230615-23-3 SDF --
Smiles Cl.C1NCC2CC1C3=CC4=NC=CN=C4C=C23
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 50 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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