Rocuronium Bromide

For research use only.

Catalog No.S1397 Synonyms: ORG 9426

Rocuronium Bromide Chemical Structure

CAS No. 119302-91-9

Rocuronium Bromide (ORG 9426) is a competitive AchR antagonist, used in modern anaesthesia.

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Biological Activity

Description Rocuronium Bromide (ORG 9426) is a competitive AchR antagonist, used in modern anaesthesia.
AChR [1]
In vitro

Rocuronium bromide (RB), an aminosteroid type neuromuscular blocking agent, acts by reducing or inhibiting the depolarising effect of acetylcholine on the terminal disc of the muscle cell. [1] Rocuronium interacts with human liver microsomal cytochromes P450 (CYP) by binding to the substrate site. Rocuronium has caused inhibition of both reactions by 20 and 15%, respectively. [2]

In vivo Rocuronium is an ideal muscle relaxant with a rapid onset, intermediate duration of action, nondepolarizing properties and lack of cardiovascular side effects. Rocuronium produces a dose-dependent duration of neuromuscular blockade in isoflurane anesthetized horses. [3] Rocuronium bromide, is a relatively low potency, intermediate-acting agent with a rapid onset time of 98 seconds in dogs. [4] Rocuronium is an effective nondepolarizing muscle relaxant in the cat under the clinical conditions of this study. Rocuronium has a rapid onset, a short duration of action. [5] Rocuronium (0.6 mg/kg) results in a significant increase in heart rate one min after IV administration in the dog. Rocuronium (0.3 mg/kg and 0.6 mg/kg) produce a reliable neuromuscular block of 23–32 min duration, respectively. [6] Rocuronium bromide paralyzes the internal laryngeal muscles keeping the vocal cords in an intermediate position (paramedial) 60 seconds after being administered in cats. [7]


Solubility (25°C)

In vitro DMSO 122 mg/mL (200.1 mM)
Water 122 mg/mL (200.1 mM)
Ethanol 122 mg/mL (200.1 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 609.68


CAS No. 119302-91-9
Storage powder
in solvent
Synonyms ORG 9426
Smiles CC(=O)OC1C(CC2C1(CCC3C2CCC4C3(CC(C(C4)O)N5CCOCC5)C)C)[N+]6(CCCC6)CC=C.[Br-]

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00675792 Completed Drug: Sugammadex|Drug: Neostigmine|Drug: Rocuronium Anesthesia Merck Sharp & Dohme Corp. May 2008 Phase 3

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AChR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID