Rocuronium Bromide

Catalog No.S1397 Synonyms: ORG 9426

Rocuronium Bromide Chemical Structure

Molecular Weight(MW): 609.68

Rocuronium Bromide is a competitive AchR antagonist, used in modern anaesthesia.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
USD 310 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Choose Selective AChR Inhibitors

Biological Activity

Description Rocuronium Bromide is a competitive AchR antagonist, used in modern anaesthesia.
Targets
AChR [1]
In vitro

Rocuronium bromide (RB), an aminosteroid type neuromuscular blocking agent, acts by reducing or inhibiting the depolarising effect of acetylcholine on the terminal disc of the muscle cell. [1] Rocuronium interacts with human liver microsomal cytochromes P450 (CYP) by binding to the substrate site. Rocuronium has caused inhibition of both reactions by 20 and 15%, respectively. [2]

In vivo Rocuronium is an ideal muscle relaxant with a rapid onset, intermediate duration of action, nondepolarizing properties and lack of cardiovascular side effects. Rocuronium produces a dose-dependent duration of neuromuscular blockade in isoflurane anesthetized horses. [3] Rocuronium bromide, is a relatively low potency, intermediate-acting agent with a rapid onset time of 98 seconds in dogs. [4] Rocuronium is an effective nondepolarizing muscle relaxant in the cat under the clinical conditions of this study. Rocuronium has a rapid onset, a short duration of action. [5] Rocuronium (0.6 mg/kg) results in a significant increase in heart rate one min after IV administration in the dog. Rocuronium (0.3 mg/kg and 0.6 mg/kg) produce a reliable neuromuscular block of 23–32 min duration, respectively. [6] Rocuronium bromide paralyzes the internal laryngeal muscles keeping the vocal cords in an intermediate position (paramedial) 60 seconds after being administered in cats. [7]

Protocol

Solubility (25°C)

In vitro DMSO 122 mg/mL (200.1 mM)
Water 122 mg/mL (200.1 mM)
Ethanol 122 mg/mL (200.1 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 609.68
Formula

C32H53N2O4.Br

CAS No. 119302-91-9
Storage powder
in solvent
Synonyms ORG 9426

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03881423 Not yet recruiting Muscle Relaxation Ain Shams University May 1 2019 Early Phase 1
NCT03881423 Not yet recruiting Muscle Relaxation Ain Shams University May 1 2019 Early Phase 1
NCT03825198 Not yet recruiting Pain Postoperative|Anaesthesia|Surgery|Nerve Block|Anesthesia Local|Back Pain|Spinal Fusion Dr M. B. Breebaart|University Hospital Antwerp March 15 2019 Phase 3
NCT03825198 Not yet recruiting Pain Postoperative|Anaesthesia|Surgery|Nerve Block|Anesthesia Local|Back Pain|Spinal Fusion Dr M. B. Breebaart|University Hospital Antwerp March 15 2019 Phase 3
NCT03782233 Enrolling by invitation Neuromuscular Blockade The First Affiliated Hospital with Nanjing Medical University|Wu Jieping Medical Foundation January 1 2019 Not Applicable
NCT03782233 Enrolling by invitation Neuromuscular Blockade The First Affiliated Hospital with Nanjing Medical University|Wu Jieping Medical Foundation January 1 2019 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

AChR Signaling Pathway Map

Related AChR Products0

Tags: buy Rocuronium Bromide | Rocuronium Bromide ic50 | Rocuronium Bromide price | Rocuronium Bromide cost | Rocuronium Bromide solubility dmso | Rocuronium Bromide purchase | Rocuronium Bromide manufacturer | Rocuronium Bromide research buy | Rocuronium Bromide order | Rocuronium Bromide mouse | Rocuronium Bromide chemical structure | Rocuronium Bromide mw | Rocuronium Bromide molecular weight | Rocuronium Bromide datasheet | Rocuronium Bromide supplier | Rocuronium Bromide in vitro | Rocuronium Bromide cell line | Rocuronium Bromide concentration | Rocuronium Bromide nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID