Catalog No.S1397 Synonyms: ORG 9426
Molecular Weight(MW): 609.68
Rocuronium Bromide is a competitive AchR antagonist, used in modern anaesthesia.
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|Description||Rocuronium Bromide is a competitive AchR antagonist, used in modern anaesthesia.|
Rocuronium bromide (RB), an aminosteroid type neuromuscular blocking agent, acts by reducing or inhibiting the depolarising effect of acetylcholine on the terminal disc of the muscle cell.  Rocuronium interacts with human liver microsomal cytochromes P450 (CYP) by binding to the substrate site. Rocuronium has caused inhibition of both reactions by 20 and 15%, respectively. 
|In vivo||Rocuronium is an ideal muscle relaxant with a rapid onset, intermediate duration of action, nondepolarizing properties and lack of cardiovascular side effects. Rocuronium produces a dose-dependent duration of neuromuscular blockade in isoflurane anesthetized horses.  Rocuronium bromide, is a relatively low potency, intermediate-acting agent with a rapid onset time of 98 seconds in dogs.  Rocuronium is an effective nondepolarizing muscle relaxant in the cat under the clinical conditions of this study. Rocuronium has a rapid onset, a short duration of action.  Rocuronium (0.6 mg/kg) results in a significant increase in heart rate one min after IV administration in the dog. Rocuronium (0.3 mg/kg and 0.6 mg/kg) produce a reliable neuromuscular block of 23–32 min duration, respectively.  Rocuronium bromide paralyzes the internal laryngeal muscles keeping the vocal cords in an intermediate position (paramedial) 60 seconds after being administered in cats. |
-  Zan U, et al. Cytotechnology,?011, 63(3), 239-245.
-  Anzenbacherova E, et al. J Pharmacol Sci,?015, 127(2), 190-195.
-  Auer U, et al. Vet Ophthalmol,?011, 14(4), 244-247.
|In vitro||DMSO||122 mg/mL (200.1 mM)|
|Water||122 mg/mL (200.1 mM)|
|Ethanol||122 mg/mL (200.1 mM)|
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