Rocuronium Bromide

Catalog No.S1397 Synonyms: ORG 9426

For research use only.

Rocuronium Bromide (ORG 9426) is a competitive AchR antagonist, used in modern anaesthesia.

Rocuronium Bromide Chemical Structure

CAS No. 119302-91-9

Purity & Quality Control

Choose Selective AChR Inhibitors

Other AChR Products

Biological Activity

Description Rocuronium Bromide (ORG 9426) is a competitive AchR antagonist, used in modern anaesthesia.
Targets
AChR [1]
In vitro

Rocuronium bromide (RB), an aminosteroid type neuromuscular blocking agent, acts by reducing or inhibiting the depolarising effect of acetylcholine on the terminal disc of the muscle cell. [1] Rocuronium interacts with human liver microsomal cytochromes P450 (CYP) by binding to the substrate site. Rocuronium has caused inhibition of both reactions by 20 and 15%, respectively. [2]

In vivo Rocuronium is an ideal muscle relaxant with a rapid onset, intermediate duration of action, nondepolarizing properties and lack of cardiovascular side effects. Rocuronium produces a dose-dependent duration of neuromuscular blockade in isoflurane anesthetized horses. [3] Rocuronium bromide, is a relatively low potency, intermediate-acting agent with a rapid onset time of 98 seconds in dogs. [4] Rocuronium is an effective nondepolarizing muscle relaxant in the cat under the clinical conditions of this study. Rocuronium has a rapid onset, a short duration of action. [5] Rocuronium (0.6 mg/kg) results in a significant increase in heart rate one min after IV administration in the dog. Rocuronium (0.3 mg/kg and 0.6 mg/kg) produce a reliable neuromuscular block of 23–32 min duration, respectively. [6] Rocuronium bromide paralyzes the internal laryngeal muscles keeping the vocal cords in an intermediate position (paramedial) 60 seconds after being administered in cats. [7]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 609.68
Formula

C32H53N2O4.Br

CAS No. 119302-91-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(=O)OC1C(CC2C1(CCC3C2CCC4C3(CC(C(C4)O)N5CCOCC5)C)C)[N+]6(CCCC6)CC=C.[Br-]

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00675792 Completed Drug: Sugammadex|Drug: Neostigmine|Drug: Rocuronium Anesthesia Merck Sharp & Dohme Corp. May 2008 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Rocuronium Bromide | Rocuronium Bromide ic50 | Rocuronium Bromide price | Rocuronium Bromide cost | Rocuronium Bromide solubility dmso | Rocuronium Bromide purchase | Rocuronium Bromide manufacturer | Rocuronium Bromide research buy | Rocuronium Bromide order | Rocuronium Bromide mouse | Rocuronium Bromide chemical structure | Rocuronium Bromide mw | Rocuronium Bromide molecular weight | Rocuronium Bromide datasheet | Rocuronium Bromide supplier | Rocuronium Bromide in vitro | Rocuronium Bromide cell line | Rocuronium Bromide concentration | Rocuronium Bromide nmr