Home Neuronal Signaling AChR inhibitor Rivastigmine For research use only.

Rivastigmine

Synonyms: SDZ-ENA 713, Exelon

Rivastigmine (SDZ-ENA 713, Exelon) is a cholinesterase inhibitor with IC50 of 5.5 μM. It inhibits acetylcholinesterase (IC50 = 4.15 µM) and butyrylcholinesterase (IC50 = 37 nM).

Rivastigmine Chemical Structure

Rivastigmine Chemical Structure

CAS: 123441-03-2

Selleck's Rivastigmine has been cited by 1 publication

Purity & Quality Control

Batch: S468701 Purity: 99.98%
99.98

Rivastigmine Related Products

Signaling Pathway

AChR Signaling Pathways

AChR Signaling Pathway

Choose Selective AChR Inhibitors

Biological Activity

Description Rivastigmine (SDZ-ENA 713, Exelon) is a cholinesterase inhibitor with IC50 of 5.5 μM. It inhibits acetylcholinesterase (IC50 = 4.15 µM) and butyrylcholinesterase (IC50 = 37 nM).
Targets
cholinesterase [1]
In Vivo
In vivo Preclinical biochemical studies indicates that rivastigmine has central nervous system selectivity over peripheral inhibition. It ameliorates memory impairment in rats with forebrain lesions. The drug is rapidly absorbed orally, with a bioavailability of 0.355 and low protein binding (40%). Its elimination halflife is less than 2 hours, and it is converted to an inactive metabolite at the site of action, bypassing hepatic metabolic pathways. Its disposition essentially is unaltered in patients with renal or hepatic impairment. It also has dosedependent effects on AChE inhibition[1].
Animal Research Animal Models Male Wistar albino rats
Dosages 0.5, 1, 1.5 and 2.5 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05768126 Recruiting
Depressive Disorder
UMC Utrecht|ZonMw: The Netherlands Organisation for Health Research and Development|St. Antonius Hospital|Tergooi Hospital
 September 29 2021 Phase 4
NCT01585272 Completed
Alzheimer''s Dementia
Novartis Pharmaceuticals|Novartis
 August 2012 Phase 4
NCT01073319 Completed
Methamphetamine Dependence|Substance Abuse|Methamphetamine Abuse
Baylor College of Medicine|National Institute on Drug Abuse (NIDA)
 July 2009 Phase 1
NCT01312363 Completed
Alzheimer''s Disease
Seoul National University Hospital|Seoul National University Bundang Hospital|Seoul St. Mary''s Hospital|Korea University|Bobath Memorial Hospital|Chung-Ang University Hosptial Chung-Ang University College of Medicine|Hanyang University|Kwandong University Myongji Hospital|Inha University Hospital|SungAe General Hospital|Ewha Womans University|Inje University|Hanyang University Seoul Hospital|Kyunghee University Medical Center|Hallym University Medical Center|Pusan National University Hospital|Konyang University Hospital|Wonkwang University Sanbon Medical Center|Yong-in Hyoja Geriatric Hospital|Jeju National University|Dong-A University Hospital
 June 2009 --
NCT00624663 Completed
Rivastigmine Toxicity
Tel-Aviv Sourasky Medical Center|Medical Corps Israel Defense Force
 January 2009 Not Applicable

Chemical Information & Solubility

Molecular Weight 250.34 Formula

C14H22N2O2
CAS No. 123441-03-2 SDF Download Rivastigmine SDF
Density 1.038 g/mL
Smiles CCN(C)C(=O)OC1=CC=CC(=C1)C(C)N(C)C
Storage (From the date of receipt) 2 years -80°C liquid

In vitro
Batch:


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Rivastigmine | Rivastigmine supplier | purchase Rivastigmine | Rivastigmine cost | Rivastigmine manufacturer | order Rivastigmine | Rivastigmine distributor