Hexamethonium Dibromide

For research use only.

Catalog No.S4069

Hexamethonium Dibromide Chemical Structure

CAS No. 55-97-0

Hexamethonium Dibromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia.

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Biological Activity

Description Hexamethonium Dibromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia.
Targets
Dopamine subtype 2 receptor [1] AChR [1]
In vitro

Hexamethonium Bromide is effective against Ach and carbachol (CCh) on the amplitude of endplate responses of rat omohyoid muscle with EC50 of 300 μM and 100 μM, respectively. Hexamethonium Bromide (50-200 μM) causes an increase in the amplitude of nerve-evoked endplate currents (e.p.cs) recorded in the presence of 0.6 μM tubocurarine. Hexamethonium Bromide is also a weak inhibitor of acetylcholinesterase activity in rat muscle homogenates with EC50 of 1.5 mM. [1] Hexamethonium Bromide (200 μM) decreases the time constant of decay of both endplate currents (e.p.cs) (by ~25%) and miniature endplate currents (m.e.p.cs) (by ~20%) in the rat hemi-diaphragm muscle. At low frequencies of stimulation (0.5-2 Hz), Hexamethonium Bromide (200 μM) increases e.p.c. quantal content by 30-40%. [2]

Protocol

Solubility (25°C)

In vitro Water 73 mg/mL (201.55 mM)
DMSO Insoluble
Ethanol Insoluble

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Chemical Information

Molecular Weight 362.19
Formula

C12H30N2.2Br

CAS No. 55-97-0
Storage powder
in solvent
Synonyms N/A
Smiles C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-]

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AChR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID