Home Neuronal Signaling AChR antagonist Hexamethonium Dibromide

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Hexamethonium Dibromide AChR antagonist

Cat.No.S4069

Hexamethonium Dibromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia.
Hexamethonium Dibromide AChR antagonist Chemical Structure

Chemical Structure

Molecular Weight: 362.19

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Batch: S406901 Water]73 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 100.00%
  • Cited in Nature Medicine for its top-tier quality
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100.00

Solubility

In vitro
Batch:

Water : 73 mg/mL

DMSO : Insoluble
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Ethanol : Insoluble

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In vivo
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Chemical Information, Storage & Stability

Molecular Weight 362.19 Formula

C12H30N2.2Br

 Storage (From the date of receipt)
CAS No. 55-97-0 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-]

Mechanism of Action

Targets/IC50/Ki
Dopamine subtype 2 receptor
AChR
In vitro
Hexamethonium Bromide is effective against Ach and carbachol (CCh) on the amplitude of endplate responses of rat omohyoid muscle with EC50 of 300 μM and 100 μM, respectively. Hexamethonium Bromide (50-200 μM) causes an increase in the amplitude of nerve-evoked endplate currents (e.p.cs) recorded in the presence of 0.6 μM tubocurarine. Hexamethonium Bromide is also a weak inhibitor of acetylcholinesterase activity in rat muscle homogenates with EC50 of 1.5 mM. Hexamethonium Bromide (200 μM) decreases the time constant of decay of both endplate currents (e.p.cs) (by ~25%) and miniature endplate currents (m.e.p.cs) (by ~20%) in the rat hemi-diaphragm muscle. At low frequencies of stimulation (0.5-2 Hz), Hexamethonium Bromide (200 μM) increases e.p.c. quantal content by 30-40%.
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/1282587/

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