Varenicline

For research use only.

Catalog No.S6985 Synonyms: Chantix, Champix

Varenicline Chemical Structure

CAS No. 249296-44-4

Varenicline is highly selective and blocks more potently to α4β2 receptors than to other common nicotinic receptors (>500-fold α3β4, >3,500-fold α7, >20,000-fold α1βγδ), or to non-nicotinic receptors and transporters (>2,000-fold). Varenicline also acts as an agonist of 5-HT3 serotonine receptors.

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Biological Activity

Description Varenicline is highly selective and blocks more potently to α4β2 receptors than to other common nicotinic receptors (>500-fold α3β4, >3,500-fold α7, >20,000-fold α1βγδ), or to non-nicotinic receptors and transporters (>2,000-fold). Varenicline also acts as an agonist of 5-HT3 serotonine receptors.
Targets
α4β2 receptors [1]
()
5-HT3 receptor [2]
()

Protocol

Solubility (25°C)

In vitro DMSO 42 mg/mL (198.8 mM)
Water 3 mg/mL (14.2 mM)
Ethanol ''''42 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 211.26
Formula

C13H13N3

CAS No. 249296-44-4
Storage powder
in solvent
Synonyms Chantix, Champix

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04317300 Not yet recruiting Drug: Varenicline|Other: brief behavioral therapy Vaping Mayo Clinic September 5 2021 Early Phase 1
NCT03980561 Recruiting Drug: Varenicline|Drug: Placebo Cannabis Use Disorder Medical University of South Carolina January 31 2020 Phase 2
NCT04072146 Completed Drug: OC-01|Drug: Chantix Healthy Subjects Oyster Point Pharma Inc. August 26 2019 Phase 1
NCT04011280 Recruiting Drug: Varenicline Bipolar Disorder|Schizophrenia|Schizoaffective Disorder|Nicotine Dependence University of California San Diego|Veterans Medical Research Foundation|University of California July 15 2019 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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AChR Signaling Pathway Map

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