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Propiverine hydrochloride

Name: Propiverine hydrochloride
Brand: Selleck Chemicals
SKU: S4931
Rating: 5 (1 reviews)

Catalog No.S4931 Purity: 99.25%

Propiverine is an anticholinergic drug used for the treatment of overactive bladder and urinary incontinence. Propiverine is a muscarinic receptor antagonist possessing additional properties, i.e., block of L-type Ca2+ channels.

Propiverine hydrochloride Chemical Structure

CAS: 54556-98-8

Purity & Quality Control

Batch: S493101 DMSO] 80 mg/mL] false] ] ] false] ] ] false Purity: 99.25%

99.25

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Signaling Pathway

Calcium Channel Signaling Pathway

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Biological Activity

Description	Propiverine is an anticholinergic drug used for the treatment of overactive bladder and urinary incontinence. Propiverine is a muscarinic receptor antagonist possessing additional properties, i.e., block of L-type Ca2+ channels.

In Vivo
In vivo	Propiverine administered orally in mice binds significantly to muscarinic receptors in the bladder and its binding activity is more prominent and longer-lasting in the bladder than in the submaxillary gland. Propiverine is well absorbed from the gastrointestinal tract and undergoes high first-pass metabolism. It is metabolized in the liver and intestine to form the active metabolites^[1].
Animal Research	Animal Models	Mice
	Dosages	74.3, 149 and 297 μmol/kg
	Administration	oral administration

References

[1] Ito Y, et al. Low Urin Tract Symptoms. 2010, 2(1):43-9.

Chemical Information & Solubility

Molecular Weight	403.94	Formula	C₂₃H₂₉NO₃.Cl H
CAS No.	54556-98-8	SDF	--
Smiles	CCCOC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OC3CCN(CC3)C.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 80 mg/mL ( (198.04 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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In vivo
Batch:

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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