Home Transmembrane Transporters Calcium Channel antagonist - AChR antagonist Propiverine hydrochloride

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Propiverine hydrochloride Calcium Channel antagonist

Cat.No.S4931

Propiverine is an anticholinergic drug used for the treatment of overactive bladder and urinary incontinence. Propiverine is a muscarinic receptor antagonist possessing additional properties, i.e., block of L-type Ca2+ channels.
Propiverine hydrochloride Calcium Channel antagonist Chemical Structure

Chemical Structure

Molecular Weight: 403.94

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Quality Control

Batch: S493101 DMSO]80 mg/mL]false]]]false]]]false Purity: 99.25%
99.25

Chemical Information, Storage & Stability

Molecular Weight 403.94 Formula

C23H29NO3.Cl H

 Storage (From the date of receipt)
CAS No. 54556-98-8 -- Storage of Stock Solutions

Synonyms N/A Smiles CCCOC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OC3CCN(CC3)C.Cl

Solubility

In vitro
Batch:

DMSO : 80 mg/mL (198.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Mechanism of Action

In vivo
Propiverine administered orally in mice binds significantly to muscarinic receptors in the bladder and its binding activity is more prominent and longer-lasting in the bladder than in the submaxillary gland. Propiverine is well absorbed from the gastrointestinal tract and undergoes high first-pass metabolism. It is metabolized in the liver and intestine to form the active metabolites[1].
References

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