Propiverine hydrochloride

For research use only.

Catalog No.S4931

Propiverine hydrochloride Chemical Structure

CAS No. 54556-98-8

Propiverine is an anticholinergic drug used for the treatment of overactive bladder and urinary incontinence. Propiverine is a muscarinic receptor antagonist possessing additional properties, i.e., block of L-type Ca2+ channels.

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Description Propiverine is an anticholinergic drug used for the treatment of overactive bladder and urinary incontinence. Propiverine is a muscarinic receptor antagonist possessing additional properties, i.e., block of L-type Ca2+ channels.
In vivo Propiverine administered orally in mice binds significantly to muscarinic receptors in the bladder and its binding activity is more prominent and longer-lasting in the bladder than in the submaxillary gland. Propiverine is well absorbed from the gastrointestinal tract and undergoes high first-pass metabolism. It is metabolized in the liver and intestine to form the active metabolites[1].

Protocol

Animal Research:

[2]

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  • Animal Models: Mice
  • Dosages: 74.3, 149 and 297 μmol/kg
  • Administration: oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 80 mg/mL (198.04 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 403.94
Formula

C23H29NO3.Cl H

CAS No. 54556-98-8
Storage powder
in solvent
Synonyms N/A
Smiles CCCOC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OC3CCN(CC3)C.Cl

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID