VU 0365114

VU 0365114 is a muscarinic acetylcholine receptor M5-preferring (mAChR M5-preferring) positive allosteric modulator (PAM) with an EC50 of 2.7 μM.

VU 0365114 Chemical Structure

VU 0365114 Chemical Structure

CAS: 1208222-39-2

Purity & Quality Control

Batch: E079901 DMSO] 79 mg/mL] false] Ethanol] 10 mg/mL] false] Water] Insoluble] false Purity: 99.68%
99.68

VU 0365114 Related Products

Signaling Pathway

Choose Selective AChR Inhibitors

Biological Activity

Description VU 0365114 is a muscarinic acetylcholine receptor M5-preferring (mAChR M5-preferring) positive allosteric modulator (PAM) with an EC50 of 2.7 μM.
Targets
mAChR M5 [1]
(in intracellular calcium mobilization assay)
2.7 μM(EC50)

Chemical Information & Solubility

Molecular Weight 397.35 Formula

C22H14F3NO3

CAS No. 1208222-39-2 SDF --
Smiles FC(F)(F)OC1=CC2=C(C=C1)N(CC3=CC=C(C=C3)C4=CC=CC=C4)C(=O)C2=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 79 mg/mL ( (198.81 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 10 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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