Home Neuronal Signaling AChR modulator VU0119498 For research use only.

VU0119498

VU0119498 is a pan Gq muscarinic acetylcholine receptor (mAChR) M1, M3, M5 positive allosteric modulator (PAM) with EC50 of 6.1 μM, 6.4 μM, 4.1 μM, respectively.

VU0119498 Chemical Structure

VU0119498 Chemical Structure

CAS: 79183-37-2

Purity & Quality Control

Batch: S078301 DMSO] 50 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.52%
99.52

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Biological Activity

Description VU0119498 is a pan Gq muscarinic acetylcholine receptor (mAChR) M1, M3, M5 positive allosteric modulator (PAM) with EC50 of 6.1 μM, 6.4 μM, 4.1 μM, respectively.
Targets
mAChR M5 [1]
(Cell-free assay)		 mAChR M1 [1]
(Cell-free assay)		 mAChR M3 [1]
(Cell-free assay)
4.1 μM 6.1 μM 6.4 μM

Chemical Information & Solubility

Molecular Weight 316.15 Formula
C15H10BrNO2
CAS No. 79183-37-2 SDF --
Smiles C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 50 mg/mL ( (158.15 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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