Rivastigmine Tartrate

Catalog No.S2087 Synonyms: ENA 713

For research use only.

Rivastigmine Tartrate (ENA 713) is a cholinesterase inhibitor with IC50 of 5.5 μM, and used as a parasympathomimetic or cholinergic agent for the treatment of mild to moderate Alzheimer disease.

Rivastigmine Tartrate Chemical Structure

CAS No. 129101-54-8

Selleck's Rivastigmine Tartrate has been cited by 1 Publication

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Biological Activity

Description Rivastigmine Tartrate (ENA 713) is a cholinesterase inhibitor with IC50 of 5.5 μM, and used as a parasympathomimetic or cholinergic agent for the treatment of mild to moderate Alzheimer disease.
Targets
AChR [1]
5.5 μM

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 400.42
Formula

C14H22N2O2.C4H6O6

CAS No. 129101-54-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCN(C)C(=O)OC1=CC=CC(=C1)C(C)N(C)C.C(C(C(=O)O)O)(C(=O)O)O

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01585272 Completed Drug: ENA713 Alzheimer''s Dementia Novartis Pharmaceuticals|Novartis August 2012 Phase 4
NCT01073319 Completed Other: Placebo|Drug: Rivastigmine Methamphetamine Dependence|Substance Abuse|Methamphetamine Abuse Baylor College of Medicine|National Institute on Drug Abuse (NIDA) July 2009 Phase 1
NCT01312363 Completed Drug: Rivastigmine patch Alzheimer''s Disease Seoul National University Hospital|Seoul National University Bundang Hospital|Seoul St. Mary''s Hospital|Korea University|Bobath Memorial Hospital|Chung-Ang University Hosptial Chung-Ang University College of Medicine|Hanyang University|Kwandong University Myongji Hospital|Inha University Hospital|SungAe General Hospital|Ewha Womans University|Inje University|Hanyang University Seoul Hospital|Kyunghee University Medical Center|Hallym University Medical Center|Pusan National University Hospital|Konyang University Hospital|Wonkwang University Sanbon Medical Center|Yong-in Hyoja Geriatric Hospital|Jeju National University|Dong-A University Hospital June 2009 --
NCT00624663 Completed Drug: Rivastigmine Rivastigmine Toxicity Tel-Aviv Sourasky Medical Center|Medical Corps Israel Defense Force January 2009 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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