Galanthamine HBr

Catalog No.S1339

For research use only.

Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase.

Galanthamine HBr Chemical Structure

CAS No. 1953-04-4

Purity & Quality Control

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Biological Activity

Description Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase.
AChE [1]
0.35 μM
In vitro

Galanthamine has been demonstrated to have an IC50 of 14 nM and 15 nM on AChE in post-mortem human brain frontal cortex and the hippocampus region. Red-cell cholinesterase activity in blood samples from the neurosurgery patients is 10 times more strongly inhibited by Galanthamine in brain tissue samples. [1] Galanthamine (1 μM) activates single channels with conductance's of 18 and 30 pS in outside-out patches excised from dexamethasone mouse fibroblasts (M10 cells). [2] Galanthamine acts as noncompetitive nicotinic receptor agonists' on clonal rat pheochromocytoma (PC12) cells. Galanthamine (50 μM) activates single-channel currents in outside-out patches excised from clonal PC12 cells. [3]

In vivo Galantamine significantly increases the number of living pyramidal neurons after ischemia-reperfusion injury. Galantamine significantly reduces TUNEL, active caspase-3, and SOD-2 immunoreactivity. The nicotinic antagonist mecamylamine blockes the protective effects of galantamine. The neuroprotective effects of galantamine are preserved even when first administered at 3 hours postischemia. [4]

Protocol (from reference)

Animal Research:[4]
  • Animal Models: Gerbils
  • Dosages: 10 mg/kg
  • Administration: S.c. twice a day or 3 or 6 hours after ischemia and at subsequent 12-hours intervals until sacrifice

Solubility (25°C)

In vitro

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
For best results, use promptly after mixing.

20 mg/mL

Chemical Information

Molecular Weight 368.27


CAS No. 1953-04-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN1CCC23C=CC(CC2OC4=C(C=CC(=C34)C1)OC)O.Br

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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