Home Neuronal Signaling ADC Cytotoxin inhibitor Galanthamine HBr

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Galanthamine HBr ADC Cytotoxin inhibitor

Cat.No.S1339

Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase.
Galanthamine HBr ADC Cytotoxin inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 368.27

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Quality Control

Batch: Purity: 99.90%
99.90

Solubility

In vitro
Batch:

Water : 10 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 368.27 Formula

C17H21NO3.HBr

 Storage (From the date of receipt)
CAS No. 1953-04-4 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CN1CCC23C=CC(CC2OC4=C(C=CC(=C34)C1)OC)O.Br

Mechanism of Action

Targets/IC50/Ki
AChE
0.35 μM
In vitro
Galanthamine has been demonstrated to have an IC50 of 14 nM and 15 nM on AChE in post-mortem human brain frontal cortex and the hippocampus region. Red-cell cholinesterase activity in blood samples from the neurosurgery patients is 10 times more strongly inhibited by Galanthamine in brain tissue samples. Galanthamine (1 μM) activates single channels with conductance's of 18 and 30 pS in outside-out patches excised from dexamethasone mouse fibroblasts (M10 cells). Galanthamine acts as noncompetitive nicotinic receptor agonists' on clonal rat pheochromocytoma (PC12) cells. Galanthamine (50 μM) activates single-channel currents in outside-out patches excised from clonal PC12 cells.
In vivo
Galantamine significantly increases the number of living pyramidal neurons after ischemia-reperfusion injury. Galantamine significantly reduces TUNEL, active caspase-3, and SOD-2 immunoreactivity. The nicotinic antagonist mecamylamine blockes the protective effects of galantamine. The neuroprotective effects of galantamine are preserved even when first administered at 3 hours postischemia.
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/17526807/

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