Umeclidinium bromide

Synonyms: GSK573719A

Umeclidinium bromide(GSK573719A) is a long-acting muscarinic antagonist approved for the maintenance treatment of chronic obstructive pulmonary disease (COPD).

Umeclidinium bromide Chemical Structure

Umeclidinium bromide Chemical Structure

CAS: 869113-09-7

Purity & Quality Control

Batch: S373501 DMSO] 100 mg/mL] false] Ethanol] 12 mg/mL] false] Water] Insoluble] false Purity: 99.81%
99.81

Umeclidinium bromide Related Products

Signaling Pathway

Choose Selective AChR Inhibitors

Biological Activity

Description Umeclidinium bromide(GSK573719A) is a long-acting muscarinic antagonist approved for the maintenance treatment of chronic obstructive pulmonary disease (COPD).
Targets
mAChR [1]
In vitro
In vitro

Umeclidinium is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium for the cloned human M1-M5 mAChRs ranged from 0.05 to 0.16 nM[1].

In Vivo
In vivo

Umeclidinium is a potent anticholinergic agent that demonstrates slow functional reversibility at the human M3 mAChR and long duration of action in animal models[1].

Chemical Information & Solubility

Molecular Weight 508.49 Formula

C29H34NO2.Br

CAS No. 869113-09-7 SDF Download Umeclidinium bromide SDF
Smiles C1C[N+]2(CCC1(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)CCOCC5=CC=CC=C5.[Br-]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (196.66 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 12 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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