For research use only.

Catalog No.S5538 Synonyms: ICS 205-930

Tropisetron Chemical Structure

CAS No. 89565-68-4

Tropisetron (ICS 205-930) is a 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.

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Biological Activity

Description Tropisetron (ICS 205-930) is a 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.
5-HT3 receptor [1]
α7 nAChR [1]
5.3 nM(Ki) 6.9 nM(Ki)
In vitro

Tropisetron inhibits antigen-induced proliferation and IL-2 production in human peripheral T cells. Tropisetron inhibits the signalling pathways that regulate the activation of the transcription factors NFAT, NF-κB and AP-1, which are known to play a critical role in the immune response[2].

In vivo Tropisetron could ameliorate the ischemic brain injury via decreasing myeloperoxidase activity and TNF-α level. Tropisetron elicits anti-inflammatory effects in experimental model of cisplatin-induced nephrotoxicity and these effects were completely 5-HT3-receptor-independent[3].


Cell Research:


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  • Cell lines: Jurkat cells
  • Concentrations: 10, 25, 50 μg/ml
  • Incubation Time: 30 min
  • Method:

    Jurkat cells (1 × 106 cells/ml) were stimulated with either TNFα (2 ng/ml) or PMA (20 ng/ml) plus ionomycin (0.5 ug/ml) for p65, JNK, ERK1 + 2, p38 and IκBα proteins in the presence or absence of tropisetron. Cells were then washed with PBS and proteins extracted in 50 μl of lysis buffer containing 0.5% NP-40. Protein concentration was determined by the Bradford assay and 30 μg of proteins were boiled in Laemmli buffer and electrophoresed in 10% SDS/polyacrylamide gels.

    (Only for Reference)
Animal Research:


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  • Animal Models: Male albino mice
  • Dosages: 3 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro Water 56 mg/mL (196.94 mM)
DMSO 10 mg/mL (35.16 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 284.35


CAS No. 89565-68-4
Storage powder
in solvent
Synonyms ICS 205-930
Smiles CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04195204 Recruiting Drug: Tropisetron|Drug: Placebos Postoperative Cognitive Dysfunction|Postoperative Delirium Beijing Chao Yang Hospital November 1 2019 Phase 4

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5-HT Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID