Home Neuronal Signaling AChR agonist GTS-21 dihydrochloride For research use only.

GTS-21 dihydrochloride

Synonyms: DMXB-A; DMBX-anabaseine

GTS-21 dihydrochloride(DMXB-A; DMBX-anabaseine) is a selective agonist of alpha7 nicotinic acetylcholine receptor (α7-nAChR) and exhibits anti‑inflammatory and cognition‑enhancing activities. GTS-21 dihydrochloride is also an antagonist of α4β2 with a Ki value of 20 nM for humanα4β2 and 5-HT3A receptor with an IC50 value of 3.1 μM.

GTS-21 dihydrochloride Chemical Structure

GTS-21 dihydrochloride Chemical Structure

CAS: 156223-05-1

Purity & Quality Control

Batch: E187601 Water] 76 mg/mL] false] DMSO] 25 mg/mL] false] Ethanol] 3 mg/mL] false Purity: 99.77%
99.77

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Biological Activity

Description GTS-21 dihydrochloride(DMXB-A; DMBX-anabaseine) is a selective agonist of alpha7 nicotinic acetylcholine receptor (α7-nAChR) and exhibits anti‑inflammatory and cognition‑enhancing activities. GTS-21 dihydrochloride is also an antagonist of α4β2 with a Ki value of 20 nM for humanα4β2 and 5-HT3A receptor with an IC50 value of 3.1 μM.

Chemical Information & Solubility

Molecular Weight 381.30 Formula

C19H20N2O2.2ClH
CAS No. 156223-05-1 SDF Download GTS-21 dihydrochloride SDF
Storage (From the date of receipt) Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

In vitro
Batch:

Water : 76 mg/mL

DMSO : 25 mg/mL ( (65.56 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 3 mg/mL


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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