mAChR Selective Inhibitors | Agonists | Antagonists

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S4031 Aclidinium Bromide

Aclidinium Bromide inhibits human muscarinic AChR M1, M2, M3, M4 and M5 with Ki of 0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM and 0.16 nM, respectively.

Selective M5 mAChR, Ki: 0.16 nM; M4 mAChR, Ki: 0.21 nM; M3 mAChR, Ki: 0.14 nM; M2 mAChR, Ki: 0.14 nM; M1 mAChR, Ki: 0.1 nM
S2659 5-hydroxymethyl Tolterodine (PNU 200577, 5-HMT, 5-HM)

5-hydroxymethyl tolterodine (PNU 200577) is a new muscarinic receptor antagonist with Kb of 0.84 nM.

Selective mAChR, Kb: 0.84 nM
S3144 Darifenacin HBr

Darifenacin is a selective M3 muscarinic receptor antagonist with pKi of 8.9.

Selective M3 mAChR, pKi: 8.9
S2130 Atropine

Atropine is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 2.5 nM.

Selective mAChR, IC50: 2.5 nM
S1913 Tropicamide

Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM.

Selective M4 mAChR, IC50: 8 nM
S2508 Scopolamine HBr

Scopolamine HBr is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 nM.

Selective mAChR, IC50: 55.3 nM
S4024 Homatropine Methylbromide

Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.

Selective mAChR (SHR-E), IC50: 170.3 nM; mAChR (WKY-E), IC50: 162.5 nM
S4025 Homatropine Bromide

Homatropine Bromide is an muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.

Selective mAChR (SHR-E), IC50: 170.3 nM; mAChR (WKY-E), IC50: 162.5 nM
S4027 Flavoxate HCl

Flavoxate is a muscarinic AChR antagonist with IC50 of 12.2 μM.

Selective mAChR, IC50: 12.2 μM
S1683 Ipratropium Bromide

Ipratropium Bromide is a muscarinic antagonist, bronchodilator, N-Isopropyl salt of atropine.

Selective
S1978 Methscopolamine

Methscopolamine is a muscarinic acetylcholine receptor blocker.

Selective
S4143 Pentoxyverine Citrate

Pentoxyverine Citrate is an antitussive (cough suppressant) commonly used for cough associated with illnesses like common cold.

Selective
S4034 Diphemanil Methylsulfate

Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).

Selective
S4292 Diphenidol HCl

Diphenidol HCl is a potent antagonist of muscarinic M2 and M3 receptor with pKb of 6.72 and 7.02, respectively, used in the treatment of vomiting and vertigo.

Selective
S3048 Solifenacin succinate

Solifenacin succinate is a urinary antispasmodic of the antimuscarinic class.

Selective
S2614 Arecoline

Arecoline is a muscarinic acetylcholine receptor agonist.

Selective
S2455 Bethanechol chloride

Bethanechol chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors.

Selective
S3047 Otilonium Bromide

Otilonium bromide is an antimuscarinic.

Selective
S4231 Pilocarpine HCl

Pilocarpine HCl is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.

Selective
S3117 Oxybutynin chloride

Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.

Selective
S1929 Irsogladine

Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.

Selective