Decamethonium Bromide

For research use only.

Catalog No.S4072

Decamethonium Bromide Chemical Structure

CAS No. 541-22-0

Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.

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Biological Activity

Description Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.
Targets
nAChR [1]
In vitro

Decamethonium (Syncurine) is a depolarizing muscle relaxant or neuromuscular blocking agent, and is used in anesthesia to induce paralysis. Decamethonium, which has a short action time, is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor. In the motor endplate, it causes depolarization, preventing further effects to the normal release of acetylcholine from the presynaptic terminal, and therefore preventing the neural stimulus from affecting the muscle. In the process of binding, decamethonium actually activates (depolarizes) the motor endplate, but since the decamethonium itself is not degraded, the membrane remains depolarized and unresponsive to normal acetylcholine release. [1]

Protocol

Solubility (25°C)

In vitro Water 84 mg/mL (200.81 mM)
DMSO 34 mg/mL (81.28 mM)
Ethanol 25 mg/mL (59.76 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 418.29
Formula

C16H38N2.2Br

CAS No. 541-22-0
Storage powder
in solvent
Synonyms N/A
Smiles C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C.[Br-].[Br-]

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AChR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID