Pilocarpine HCl

For research use only.

Catalog No.S4231 Synonyms: NSC 5746 HCl

7 publications

Pilocarpine HCl Chemical Structure

CAS No. 54-71-7

Pilocarpine HCl (NSC 5746) is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.

Selleck's Pilocarpine HCl has been cited by 7 publications

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Biological Activity

Description Pilocarpine HCl (NSC 5746) is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.
Targets
mAChR [1]
In vitro

Pilocarpine is a parasympathomimetic alkaloid obtained from the leaves of tropical American shrubs from the genus Pilocarpus. It is a non-selective muscarinic receptor agonist in the parasympathetic nervous system, which acts therapeutically at themuscarinic acetylcholine receptor M3 due to its topical application, e.g., in glaucoma and xerostomia. Pilocarpine acts on a subtype of muscarinic receptor (M3) found on the iris sphincter muscle, causing the muscle to contract and engage in miosis. [1] Pilocarpine also acts on the ciliary muscle and causes it to contract. When the ciliary muscle contracts, it opens the trabecular meshwork through increased tension on the scleral spur. This action facilitates the rate that aqueous humorleaves the eye to decrease intraocular pressure. In ophthalmology, pilocarpine is also used to reduce the possibility of glare at night from lights when the patient has undergone implantation of phakic intraocular lenses; the use of pilocarpine would reduce the size of the pupils, relieving these symptoms. The most common concentration for this use is pilocarpine 1%, the weakest concentration. Pilocarpine is also used to treat dry mouth (xerostomia) which can occur, for example, as a side effect of radiation therapy for head and neck cancers. Pilocarpine stimulates the secretion of large amounts of saliva and sweat.[2]

Protocol

Solubility (25°C)

In vitro DMSO 48 mg/mL (196.14 mM)
Water 48 mg/mL (196.14 mM)
Ethanol 48 mg/mL (196.14 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 244.72
Formula

C11H16N2O2.HCl

CAS No. 54-71-7
Storage powder
in solvent
Synonyms NSC 5746 HCl
Smiles CCC1C(COC1=O)CC2=CN=CN2C.Cl

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05006898 Completed Combination Product: PBO to control presbyopia symptoms Presbyopia Optall Vision June 1 2020 Phase 1
NCT04005079 Terminated Drug: Pilocarpine|Drug: Ofloxacin|Drug: Prednisolone Open Angle Glaucoma|Ocular Hypertension Montefiore Medical Center June 5 2019 Phase 3
NCT03912792 Withdrawn -- XLHED Dermelix Biotherapeutics LLC. June 28 2019 --
NCT03825081 Unknown status Drug: Brimonidine pilocarpine Presbyopia|Pseudophakia Massachusetts Eye and Ear Infirmary January 21 2019 Early Phase 1
NCT02807415 Completed Drug: Lumacaftor plus Ivacaftor Cystic Fibrosis Hannover Medical School|Heidelberg University|University of Giessen June 1 2016 --

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AChR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID