Home Neuronal Signaling AChR antagonist Diphemanil Methylsulfate For research use only.

Diphemanil Methylsulfate

Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).

Diphemanil Methylsulfate Chemical Structure

Diphemanil Methylsulfate Chemical Structure

CAS: 62-97-5

Purity & Quality Control

Batch: S403401 DMSO] 25 mg/mL] false] Water] 18 mg/mL] false] Ethanol] Insoluble] false Purity: 99.78%
99.78

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Biological Activity

Description Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).
Targets
mAChR [1]
In vitro
In vitro Diphemanil Methylsulfate exerts its action by primarily binding the muscarinic M3 receptor. In addition to its well known antimuscarinic effects, Diphemanil Methylsulfate also possesses direct smooth muscle spasmolytic activity.
In Vivo
In vivo The pharmacokinetic experiments show that absorption of diphemanil methylsulphate is slow (tmax = 2 to 4 h), the mean half-life is 8.35 h, and the amount of the drug recovered in urine within 48 h ranges from 0.6 to 7.4% of the administered dose[1]. Poorly absorbed from the gastrointestinal tract with an absolute bioavailability of 15 to 25%.

Chemical Information & Solubility

Molecular Weight 389.51 Formula

C20H24N.CH3O4S
CAS No. 62-97-5 SDF Download Diphemanil Methylsulfate SDF
Smiles C[N+]1(CCC(=C(C2=CC=CC=C2)C3=CC=CC=C3)CC1)C.COS(=O)(=O)[O-]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 25 mg/mL ( (64.18 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 18 mg/mL

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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