Home Metabolism PDE inhibitor - AChR inhibitor Irsogladine

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Irsogladine PDE inhibitor

Cat.No.S1929

Irsogladine(Dicloguamine) is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.
Irsogladine PDE inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 256.09

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S192901 DMSO]2 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.89%
99.89

Chemical Information, Storage & Stability

Molecular Weight 256.09 Formula

C9H7Cl2N5

 Storage (From the date of receipt)
CAS No. 57381-26-7 Download SDF Storage of Stock Solutions

Synonyms Dicloguamine Smiles C1=CC(=C(C=C1Cl)C2=NC(=NC(=N2)N)N)Cl

Solubility

In vitro
Batch:

DMSO : 2 mg/mL (7.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
AChR [1]
mAChR [1]
PDE [1]

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02759224 Completed
Gastric Ulcer
Boryung Pharmaceutical Co. Ltd
 April 15 2016 Phase 1
NCT02581696 Completed
Peptic Ulcer
Boryung Pharmaceutical Co. Ltd|The Catholic University of Korea
 August 2015 Phase 1

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