Home Metabolism PDE inhibitor - AChR inhibitor Irsogladine For research use only.

Irsogladine

Synonyms: Dicloguamine

Irsogladine(Dicloguamine) is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.

Irsogladine Chemical Structure

Irsogladine Chemical Structure

CAS: 57381-26-7

Purity & Quality Control

Batch: S192901 DMSO] 2 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.89%
99.89

Irsogladine Related Products

Signaling Pathway

PDE Signaling Pathways

PDE Signaling Pathway

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Biological Activity

Description Irsogladine(Dicloguamine) is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.
Targets
AChR [1] mAChR [1] PDE [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02759224 Completed
Gastric Ulcer
Boryung Pharmaceutical Co. Ltd
 April 15 2016 Phase 1
NCT02581696 Completed
Peptic Ulcer
Boryung Pharmaceutical Co. Ltd|The Catholic University of Korea
 August 2015 Phase 1

Chemical Information & Solubility

Molecular Weight 256.09 Formula

C9H7Cl2N5
CAS No. 57381-26-7 SDF Download Irsogladine SDF
Smiles C1=CC(=C(C=C1Cl)C2=NC(=NC(=N2)N)N)Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 2 mg/mL ( (7.8 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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