Name: Homatropine Bromide
Brand: Selleck Chemicals
SKU: S4025
Rating: 5 (1 reviews)

Homatropine Bromide is an muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.

Homatropine Bromide Chemical Structure

CAS: 51-56-9

Purity & Quality Control

Batch: S402501 DMSO] 71 mg/mL] false] Water] 71 mg/mL] false] Ethanol] Insoluble] false Purity: 99.99%

99.99

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Signaling Pathway

AChR Signaling Pathway

Choose Selective AChR Inhibitors

Biological Activity

Description

Homatropine Bromide is an muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.

Targets

mAChR (WKY-E) ^[1]	mAChR (SHR-E) ^[1]
162.5 nM	170.3 nM

In vitro
In vitro	Homatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs. ^[2] Homatropine has similar affinities for muscarinic receptors in stomach (pA2 = 7.13) and for those in atria mediating force (pA2 = 7.21) and rate (pA2 = 7.07) responses. ^[3]

In Vivo
In vivo	Homatropine (20 mg/kg) prevents lethality in rats with dichlorvos poisoning with survive rate of 30% and time of death ranged between 4 and 12 minutes, while Homatropine (10 mg/kg) has no effect on preventing lethality. ^[4] Homatropine [¹⁴C]methylbromide administrated rectal achieves higher and rapid peak plasma concentrations than by the other routes in rats whether HMB-14C is administered in a water-soluble suppository base or in aqueous solution, retained 28% of the 14C has been excreted in the urine while 56% remained in the large intestine after 12 hours. Unlabelled Homatropine methylbromide, given in rectal suppositories to anaesthetized rats, causes prompt blockade of the effects of vagal stimulation on pulse rate and of intravenous acetylcholine on blood pressure. ^[5]
Animal Research	Animal Models	Sprague-Dawley rats
	Dosages	20 mg/kg
	Administration	Intramuscular (IM) injections

References

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Chemical Information & Solubility

Molecular Weight	356.25	Formula	C₁₆H₂₁NO₃.HBr
CAS No.	51-56-9	SDF	--
Smiles	CN1C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O.Br
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 71 mg/mL ( (199.29 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 71 mg/mL

Ethanol : Insoluble

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In vivo
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