Home GPCR & G Protein AChR inhibitor Imidafenacin For research use only.

Imidafenacin

Synonyms: KRP-197, ONO-8025

Imidafenacin (KRP-197, ONO-8025) is a urinary antispasmodic of the anticholinergic class. It is a novel antimuscarinic agent with safety and efficacy, has been clinically used for the treatment of overactive bladder. Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM). IC50 value: 0.3 nM(M3).

Imidafenacin Chemical Structure

Imidafenacin Chemical Structure

CAS: 170105-16-5

Purity & Quality Control

Batch: S538501 DMSO] 63 mg/mL] false] ] ] false] ] ] false Purity: 99.6%
99.6

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Signaling Pathway

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Biological Activity

Description Imidafenacin (KRP-197, ONO-8025) is a urinary antispasmodic of the anticholinergic class. It is a novel antimuscarinic agent with safety and efficacy, has been clinically used for the treatment of overactive bladder. Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM). IC50 value: 0.3 nM(M3).
Targets
M3 receptor [1]
(Cell-free assay)		 M3 receptor [1]
(Cell-free assay)		 M2 receptor [1]
(Cell-free assay)
0.3 nM 0.317 nM(Kd) 4.13 nM

Chemical Information & Solubility

Molecular Weight 319.40 Formula

C20H21N3O
CAS No. 170105-16-5 SDF --
Density g/mL
Smiles CC1=NC=CN1CCC(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 63 mg/mL ( (197.24 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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