Name: Encenicline (EVP-6124) hydrochloride
Brand: Selleck Chemicals
SKU: S2957
Rating: 5 (1 reviews)

Encenicline (EVP-6124) hydrochloride is a selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors.

Encenicline (EVP-6124) hydrochloride Chemical Structure

CAS: 550999-74-1

Purity & Quality Control

Batch: S295701 DMSO] 71 mg/mL] false] Ethanol] 35 mg/mL] false] Water] Insoluble] false Purity: 99.34%

99.34

Encenicline (EVP-6124) hydrochloride Related Products

Related Targets	mAChR nAChR AChE	Click to Expand
Related Compound Libraries	FDA-approved Drug Library Natural Product Library Neuronal Signaling Compound Library CNS-Penetrant Compound Library Anti-alzheimer Disease Compound Library	Click to Expand

Signaling Pathway

AChR Signaling Pathway

Choose Selective AChR Inhibitors

Biological Activity

Description

Encenicline (EVP-6124) hydrochloride is a selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors.

Targets

α7 nAChR ^[1]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT02246075	Withdrawn	Alzheimer''s Disease\|Dementia\|Cognition	FORUM Pharmaceuticals Inc\|Quintiles Inc.	July 2015	Phase 2
NCT02327182	Terminated	Alzheimer''s Disease	Mitsubishi Tanabe Pharma Corporation	December 2014	Phase 3
NCT02004392	Terminated	Alzheimer''s Disease\|Dementia	FORUM Pharmaceuticals Inc	June 2014	Phase 3
NCT01969123	Terminated	Alzheimer''s Disease\|Dementia	FORUM Pharmaceuticals Inc	October 2013	Phase 3
NCT01969136	Terminated	Alzheimer''s Disease\|Dementia	FORUM Pharmaceuticals Inc	October 2013	Phase 3
NCT01984736	Completed	Hepatic Impairment	FORUM Pharmaceuticals Inc\|PRA Health Sciences	June 2013	Phase 1

References

[1] Prickaerts J, et al. Neuropharmacology. 2012 Feb;62(2):1099-110.

Chemical Information & Solubility

Molecular Weight	357.3	Formula	C₁₆H₁₇ClN₂OS.ClH
CAS No.	550999-74-1	SDF	--
Smiles	Cl.ClC1=C2SC(=CC2=CC=C1)C(=O)NC3CN4CCC3CC4
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 71 mg/mL ( (198.71 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 35 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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