Encenicline (EVP-6124) hydrochloride

Catalog No.S2957

For research use only.

Encenicline (EVP-6124) hydrochloride is a selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors.

Encenicline (EVP-6124) hydrochloride Chemical Structure

CAS No. 550999-74-1

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Biological Activity

Description Encenicline (EVP-6124) hydrochloride is a selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors.
Targets
α7 nAChR [1]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 357.3
Formula

C16H17ClN2OS.ClH

CAS No. 550999-74-1
Storage 3 years -20°C powder
2 years -80°C in solvent

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02246075 Withdrawn Drug: EVP-6124 Alzheimer''s Disease|Dementia|Cognition FORUM Pharmaceuticals Inc|Quintiles Inc. July 2015 Phase 2
NCT02327182 Terminated Drug: MT-4666 Alzheimer''s Disease Mitsubishi Tanabe Pharma Corporation December 2014 Phase 3
NCT02004392 Terminated Drug: EVP-6124 Alzheimer''s Disease|Dementia FORUM Pharmaceuticals Inc June 2014 Phase 3
NCT01969123 Terminated Drug: Drug: EVP-6124|Drug: Placebo Alzheimer''s Disease|Dementia FORUM Pharmaceuticals Inc October 2013 Phase 3
NCT01969136 Terminated Drug: Drug: EVP-6124|Drug: Placebo Alzheimer''s Disease|Dementia FORUM Pharmaceuticals Inc October 2013 Phase 3
NCT01984736 Completed Drug: Experimental: EVP-6124 Hepatic Impairment FORUM Pharmaceuticals Inc|PRA Health Sciences June 2013 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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