Home Neuronal Signaling AChR agonist Encenicline (EVP-6124) hydrochloride

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Encenicline (EVP-6124) hydrochloride AChR agonist

Cat.No.S2957

Encenicline (EVP-6124) hydrochloride is a selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors.
Encenicline (EVP-6124) hydrochloride AChR agonist Chemical Structure

Chemical Structure

Molecular Weight: 357.3

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Quality Control

Batch: S295701 DMSO]71 mg/mL]false]Ethanol]35 mg/mL]false]Water]Insoluble]false Purity: 99.34%
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99.34

Solubility

In vitro
Batch:

DMSO : 71 mg/mL (198.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 35 mg/mL

Water : Insoluble

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In vivo
Batch:

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 357.3 Formula

C16H17ClN2OS.ClH

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 550999-74-1 -- Storage of Stock Solutions

Synonyms N/A Smiles Cl.ClC1=C2SC(=CC2=CC=C1)C(=O)NC3CN4CCC3CC4

Mechanism of Action

Targets/IC50/Ki
α7 nAChR
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02246075 Withdrawn
Alzheimer''s Disease|Dementia|Cognition
FORUM Pharmaceuticals Inc|Quintiles Inc.
 July 2015 Phase 2
NCT02327182 Terminated
Alzheimer''s Disease
Mitsubishi Tanabe Pharma Corporation
 December 2014 Phase 3
NCT02004392 Terminated
Alzheimer''s Disease|Dementia
FORUM Pharmaceuticals Inc
 June 2014 Phase 3
NCT01969123 Terminated
Alzheimer''s Disease|Dementia
FORUM Pharmaceuticals Inc
 October 2013 Phase 3
NCT01969136 Terminated
Alzheimer''s Disease|Dementia
FORUM Pharmaceuticals Inc
 October 2013 Phase 3
NCT01984736 Completed
Hepatic Impairment
FORUM Pharmaceuticals Inc|PRA Health Sciences
 June 2013 Phase 1

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