Pancuronium dibromide

For research use only.

Catalog No.S2497

2 publications

Pancuronium dibromide Chemical Structure

CAS No. 15500-66-0

Pancuronium dibromide is a competitive nicotinic acetylcholine receptor antagonist, used as a muscle relaxant.

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Biological Activity

Description Pancuronium dibromide is a competitive nicotinic acetylcholine receptor antagonist, used as a muscle relaxant.
Targets
AChR [1]
In vitro

Pancuronium results in open channel block of embryonic-type nicotinic acetylcholine receptor channels after coapplication of blocker and acetylcholine, characterized by decrease of the time constant of current decay. Pancuronium also results in competitive block of embryonic-type nicotinic acetylcholine receptor channels. [1] Pancuronium increases heart rate, vecuronium and rocuronium produces positive inotropic effects, and vecuronium shortens refractoriness in isolated rat atria.  [2] Pancuronium (0.5 mM) induces a complete fade of the tetanic contraction while leaving the twitch unaffected in the extensor digitorum longus muscle of the rat. Pancuronium decreases the amplitude and increases the tetanic rundown of trains of endplate potentials (e.p.ps) evoked in the frequency of 50 Hz in the extensor digitorum longus muscle of the rat.[3]

In vivo Pancuronium decreases tidal volume (VT) and minute ventilation (VE) in high dose dogs by 82%. Pancuronium decreases tidal volume (VT) and minute ventilation (VE) in low dose dogs by 40% and 55%. [4] Pancuronium limits cerebral hyperemia during prolonged seizures by attenuating increases in blood pressure as a result of elimination of skeletal muscle activity in newborn pigs. [5] Pancuronium results in a significant difference with control is observed at gallamine concentrations ranging from 0.032-0.32 mM  in tracheal smooth muscle strips from guinea-pigs.[6]

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (136.48 mM)
Water 100 mg/mL (136.48 mM)
Ethanol 100 mg/mL (136.48 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 732.67
Formula

C35H60N2O4.2Br

CAS No. 15500-66-0
Storage powder
in solvent
Synonyms N/A
Smiles CC(=O)OC1CC2CCC3C(C2(CC1[N+]4(CCCCC4)C)C)CCC5(C3CC(C5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-].[Br-]

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AChR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID