Levetiracetam (UCB-L059)

Catalog No.S1356 Synonyms: SIB-S1

For research use only.

Levetiracetam (UCB-L059, SIB-S1) is an anticonvulsant medication used to treat epilepsy. Levetiracetam (UCB-L059, SIB-S1) is an agonist of muscarinic acetylcholine receptors (mAChR). Levetiracetam modulates the presynaptic P/Q-type voltage-dependent calcium (Ca2+) channel.

Levetiracetam (UCB-L059) Chemical Structure

CAS No. 102767-28-2

Selleck's Levetiracetam (UCB-L059) has been cited by 3 Publications

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Biological Activity

Description Levetiracetam (UCB-L059, SIB-S1) is an anticonvulsant medication used to treat epilepsy. Levetiracetam (UCB-L059, SIB-S1) is an agonist of muscarinic acetylcholine receptors (mAChR). Levetiracetam modulates the presynaptic P/Q-type voltage-dependent calcium (Ca2+) channel.
Targets
Calcium channel [1]
In vitro

Levetiracetam and related compounds bind to SV2A expressed in fibroblasts, indicating that SV2A is sufficient for Levetiracetam binding. [1] Levetiracetam irreversibly inhibits the high-voltage-activated (HVA) calcium current by approximately 18% on the average in freshly isolated CA1 hippocampal neurons of rats. Levetiracetam selectively inhibits N-type Ca2+ channels of CA1 pyramidal hippocampal neurons. [2] Levetiracetam reverses the inhibitory effect of DMCM on GABA-elicited currents in hippocampal neurons. [3]

In vivo Levetiracetam (17 mg/kg) produces a potent suppression of sound-induced clonic convulsions in mice, and this protective effect is significantly abolished by co-administration of the beta-carboline FG 7142. [3] Levetiracetam exerts potent anticonvulsant activity against both focal and secondarily generalized seizures in fully amygdala-kindled rats, i.e. , a model of temporal lobe epilepsy. Levetiracetam (13 mg/kg, 27 mg/kg or 54 mg/kg, i.p.) dose-dependently suppresses the increase in seizure severity and duration induced by repeated amygdala stimulation. Levetiracetam has a relatively short half-life (about 2-3 hours) in rats. [4] Levetiracetam (5.4 mg/kg to 96 mg/kg i.p.) dose-dependently inhibits both wild running and tonic-clonic convulsions in the audiogenic-seizure prone rat. Levetiracetam markedly suppresses spontaneous spike-and-wave discharge (SWD) but leaves the underlying EEG trace normal in the GAERS model of petit mal epilepsy. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.

30 mg/mL

Chemical Information

Molecular Weight 170.21
Formula

C8H14N2O2

CAS No. 102767-28-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCC(C(=O)N)N1CCCC1=O

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04425798 Not yet recruiting -- Glioma|Epilepsy Beijing Neurosurgical Institute|Beijing Tiantan Hospital May 25 2022 --
NCT04117425 Not yet recruiting Biological: biological collection Epilepsy in Pregnancy Assistance Publique - Hôpitaux de Paris September 2021 Not Applicable
NCT04836559 Recruiting Drug: JNJ-40411813|Drug: Placebo Focal Onset Seizures Janssen Research & Development LLC May 18 2021 Phase 2
NCT04836481 Recruiting Other: Serum Sample Collection Traumatic Brain Injury University of Cincinnati|American College of Clinical Pharmacy January 1 2021 --
NCT04776486 Recruiting Drug: Iohexol Augmented Renal Clearance|Critically Ill Assistance Publique - Hôpitaux de Paris September 3 2020 Not Applicable
NCT04317807 Recruiting Drug: Levetiracetam Pill|Other: Placebo Early Psychosis NYU Langone Health August 1 2020 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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