Catalog No.S1356 Synonyms: UCB-L059, SIB-S1
Molecular Weight(MW): 170.21
Levetiracetam is an anticonvulsant medication used to treat epilepsy.
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Levetiracetam reduces DNA, synaptic, and neurite damage caused by Dox. (A) An example of cortical cultures pre-treated with 5 μ M Lev and then Dox (0.01 μ M, overnight), fixed and stained with antibodies against MAP2c. Scale bar is 20 μ m. (B) Cortical neurons at 28–32 DIV were pre-treated with 5 μ M Lev, and then a vehicle or with Dox (0.01 μ M for 3 days, or 0.1 μ M, overnight) was added. Neurons were fixed, and stained for MAP2c, synapsin, and with the Hoechst dye, and imaged. Note that red MAP2c staining also includes Dox's red fluorescence. (C) Synaptically developed primary cortical cultures at 28−32 DIV were pretreated with 5 mM Lev, and then a vehicle or with Dox (0.01 μM for 3 days, or 0.1 μM, overnight) was added. Neurons were then fixed, and stained with antibodies against γH2A.X and MAP2c, and with the Hoechst dye. Blue staining was used by the algorithm to identify and analyze γH2A.X.
Sci Rep, 2016, 6:25705.. Levetiracetam purchased from Selleck.
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|Description||Levetiracetam is an anticonvulsant medication used to treat epilepsy.|
Levetiracetam and related compounds bind to SV2A expressed in fibroblasts, indicating that SV2A is sufficient for Levetiracetam binding.  Levetiracetam irreversibly inhibits the high-voltage-activated (HVA) calcium current by approximately 18% on the average in freshly isolated CA1 hippocampal neurons of rats. Levetiracetam selectively inhibits N-type Ca2+ channels of CA1 pyramidal hippocampal neurons.  Levetiracetam reverses the inhibitory effect of DMCM on GABA-elicited currents in hippocampal neurons. 
|In vivo||Levetiracetam (17 mg/kg) produces a potent suppression of sound-induced clonic convulsions in mice, and this protective effect is significantly abolished by co-administration of the beta-carboline FG 7142.  Levetiracetam exerts potent anticonvulsant activity against both focal and secondarily generalized seizures in fully amygdala-kindled rats, i.e. , a model of temporal lobe epilepsy. Levetiracetam (13 mg/kg, 27 mg/kg or 54 mg/kg, i.p.) dose-dependently suppresses the increase in seizure severity and duration induced by repeated amygdala stimulation. Levetiracetam has a relatively short half-life (about 2-3 hours) in rats.  Levetiracetam (5.4 mg/kg to 96 mg/kg i.p.) dose-dependently inhibits both wild running and tonic-clonic convulsions in the audiogenic-seizure prone rat. Levetiracetam markedly suppresses spontaneous spike-and-wave discharge (SWD) but leaves the underlying EEG trace normal in the GAERS model of petit mal epilepsy. |
-  Gigant B, et al. Nature, 2005, 435(7041), 519-522.
-  Lukyanetz EA, et al. Epilepsia, 2002, 43(1), 9-18.
-  Rigo JM, et al. Br J Pharmacol, 2002, 136(5), 659-672.
|In vitro||DMSO||34 mg/mL (199.75 mM)|
|Water||34 mg/mL (199.75 mM)|
|Ethanol||34 mg/mL (199.75 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04117425||Not yet recruiting||Biological: biological collection||Epilepsy in Pregnancy||Assistance Publique - Hôpitaux de Paris||October 2019||Not Applicable|
|NCT03489044||Enrolling by invitation||Drug: Levetiracetam|Drug: Placebo Oral Tablet||Alzheimer Disease|Epilepsy||University of Oxford|Oxford University Hospitals NHS Trust|Oxford Health NHS Foundation Trust|Northumberland Tyne and Wear NHS Foundation Trust|UCB Pharma||November 2018||Phase 2|
|NCT02229123||Recruiting||Drug: Intravenous Levetiracetam||Neonatal Seizures||University Hospital Tours|European Georges Pompidou Hospital|Rennes University Hospital|University of Paris 5 - Rene Descartes||February 27 2018||Phase 2|
|NCT03107507||Unknown status||Drug: Levetiracetam|Drug: Phenobarbital||Neonatal Seizures||Cairo University||March 25 2017||Phase 4|
|NCT02607891||Completed||Drug: GWP42003-P|Drug: Placebo||Epilepsy||GW Research Ltd||November 9 2016||Phase 2|
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