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Levetiracetam (UCB-L059)

Name: Levetiracetam (UCB-L059)
Brand: Selleck Chemicals
SKU: S1356
Rating: 5 (5 reviews)

Synonyms: UCB-L059, SIB-S1

Catalog No.S1356 Purity: 99.99%

Levetiracetam (UCB-L059, SIB-S1) is an anticonvulsant medication used to treat epilepsy. Levetiracetam (UCB-L059, SIB-S1) is an agonist of muscarinic acetylcholine receptors (mAChR). Levetiracetam modulates the presynaptic P/Q-type voltage-dependent calcium (Ca2+) channel.

Levetiracetam (UCB-L059) Chemical Structure

CAS: 102767-28-2

Selleck's Levetiracetam (UCB-L059) has been cited by 5 Publications

1 Customer Review

Purity & Quality Control

Batch: Purity: 99.99%

99.99

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Signaling Pathway

Calcium Channel Signaling Pathway

Choose Selective Calcium Channel Inhibitors

Biological Activity

Description

Targets

Calcium channel ^[1]

In vitro
In vitro	Levetiracetam and related compounds bind to SV2A expressed in fibroblasts, indicating that SV2A is sufficient for Levetiracetam binding. ^[1] Levetiracetam irreversibly inhibits the high-voltage-activated (HVA) calcium current by approximately 18% on the average in freshly isolated CA1 hippocampal neurons of rats. Levetiracetam selectively inhibits N-type Ca2+ channels of CA1 pyramidal hippocampal neurons. ^[2] Levetiracetam reverses the inhibitory effect of DMCM on GABA-elicited currents in hippocampal neurons. ^[3]

In Vivo
In vivo	Levetiracetam (17 mg/kg) produces a potent suppression of sound-induced clonic convulsions in mice, and this protective effect is significantly abolished by co-administration of the beta-carboline FG 7142. ^[3] Levetiracetam exerts potent anticonvulsant activity against both focal and secondarily generalized seizures in fully amygdala-kindled rats, i.e. , a model of temporal lobe epilepsy. Levetiracetam (13 mg/kg, 27 mg/kg or 54 mg/kg, i.p.) dose-dependently suppresses the increase in seizure severity and duration induced by repeated amygdala stimulation. Levetiracetam has a relatively short half-life (about 2-3 hours) in rats. ^[4] Levetiracetam (5.4 mg/kg to 96 mg/kg i.p.) dose-dependently inhibits both wild running and tonic-clonic convulsions in the audiogenic-seizure prone rat. Levetiracetam markedly suppresses spontaneous spike-and-wave discharge (SWD) but leaves the underlying EEG trace normal in the GAERS model of petit mal epilepsy. ^[5]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05860153	Not yet recruiting	Febrile Convulsion	Assiut University	June 1 2023	Not Applicable
NCT06067412	Completed	Status Epilepticus	Shaheed Zulfiqar Ali Bhutto Medical University	August 1 2022	Not Applicable
NCT04425798	Unknown status	Glioma\|Epilepsy	Beijing Neurosurgical Institute\|Beijing Tiantan Hospital	May 25 2022	--
NCT04117425	Recruiting	Epilepsy in Pregnancy	Assistance Publique - Hôpitaux de Paris	April 20 2022	Not Applicable
NCT04836559	Active not recruiting	Focal Onset Seizures	Janssen Research & Development LLC	May 18 2021	Phase 2

References

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Chemical Information & Solubility

Molecular Weight	170.21	Formula	C₈H₁₄N₂O₂
CAS No.	102767-28-2	SDF	Download Levetiracetam (UCB-L059) SDF
Smiles	CCC(C(=O)N)N1CCCC1=O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 34 mg/mL ( (199.75 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 34 mg/mL

Ethanol : 34 mg/mL

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In vivo
Batch:

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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