Levetiracetam (UCB-L059)

For research use only.

Catalog No.S1356 Synonyms: SIB-S1

2 publications

Levetiracetam (UCB-L059) Chemical Structure

CAS No. 102767-28-2

Levetiracetam (UCB-L059, SIB-S1) is an anticonvulsant medication used to treat epilepsy. Levetiracetam (UCB-L059, SIB-S1) is an agonist of muscarinic acetylcholine receptors (mAChR). Levetiracetam modulates the presynaptic P/Q-type voltage-dependent calcium (Ca2+) channel.

Selleck's Levetiracetam (UCB-L059) has been cited by 2 publications

1 Customer Review

  • Levetiracetam reduces DNA, synaptic, and neurite damage caused by Dox. (A) An example of cortical cultures pre-treated with 5 μ M Lev and then Dox (0.01 μ M, overnight), fixed and stained with antibodies against MAP2c. Scale bar is 20 μ m. (B) Cortical neurons at 28–32 DIV were pre-treated with 5 μ M Lev, and then a vehicle or with Dox (0.01 μ M for 3 days, or 0.1 μ M, overnight) was added. Neurons were fixed, and stained for MAP2c, synapsin, and with the Hoechst dye, and imaged. Note that red MAP2c staining also includes Dox's red fluorescence. (C) Synaptically developed primary cortical cultures at 28−32 DIV were pretreated with 5 mM Lev, and then a vehicle or with Dox (0.01 μM for 3 days, or 0.1 μM, overnight) was added. Neurons were then fixed, and stained with antibodies against γH2A.X and MAP2c, and with the Hoechst dye. Blue staining was used by the algorithm to identify and analyze γH2A.X.

    Sci Rep, 2016, 6:25705.. Levetiracetam (UCB-L059) purchased from Selleck.

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Biological Activity

Description Levetiracetam (UCB-L059, SIB-S1) is an anticonvulsant medication used to treat epilepsy. Levetiracetam (UCB-L059, SIB-S1) is an agonist of muscarinic acetylcholine receptors (mAChR). Levetiracetam modulates the presynaptic P/Q-type voltage-dependent calcium (Ca2+) channel.
Targets
Calcium channel [1]
In vitro

Levetiracetam and related compounds bind to SV2A expressed in fibroblasts, indicating that SV2A is sufficient for Levetiracetam binding. [1] Levetiracetam irreversibly inhibits the high-voltage-activated (HVA) calcium current by approximately 18% on the average in freshly isolated CA1 hippocampal neurons of rats. Levetiracetam selectively inhibits N-type Ca2+ channels of CA1 pyramidal hippocampal neurons. [2] Levetiracetam reverses the inhibitory effect of DMCM on GABA-elicited currents in hippocampal neurons. [3]

In vivo Levetiracetam (17 mg/kg) produces a potent suppression of sound-induced clonic convulsions in mice, and this protective effect is significantly abolished by co-administration of the beta-carboline FG 7142. [3] Levetiracetam exerts potent anticonvulsant activity against both focal and secondarily generalized seizures in fully amygdala-kindled rats, i.e. , a model of temporal lobe epilepsy. Levetiracetam (13 mg/kg, 27 mg/kg or 54 mg/kg, i.p.) dose-dependently suppresses the increase in seizure severity and duration induced by repeated amygdala stimulation. Levetiracetam has a relatively short half-life (about 2-3 hours) in rats. [4] Levetiracetam (5.4 mg/kg to 96 mg/kg i.p.) dose-dependently inhibits both wild running and tonic-clonic convulsions in the audiogenic-seizure prone rat. Levetiracetam markedly suppresses spontaneous spike-and-wave discharge (SWD) but leaves the underlying EEG trace normal in the GAERS model of petit mal epilepsy. [5]

Protocol

Solubility (25°C)

In vitro DMSO 34 mg/mL (199.75 mM)
Water 34 mg/mL (199.75 mM)
Ethanol '34 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 170.21
Formula

C8H14N2O2

CAS No. 102767-28-2
Storage powder
in solvent
Synonyms SIB-S1
Smiles CCC(C(=O)N)N1CCCC1=O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04425798 Not yet recruiting -- Glioma|Epilepsy Beijing Neurosurgical Institute|Beijing Tiantan Hospital May 25 2022 --
NCT04117425 Not yet recruiting Biological: biological collection Epilepsy in Pregnancy Assistance Publique - Hôpitaux de Paris September 2021 Not Applicable
NCT04836559 Recruiting Drug: JNJ-40411813|Drug: Placebo Focal Onset Seizures Janssen Research & Development LLC April 7 2021 Phase 2
NCT04836481 Recruiting Other: Serum Sample Collection Traumatic Brain Injury University of Cincinnati|American College of Clinical Pharmacy January 1 2021 --
NCT04776486 Recruiting Drug: Iohexol Augmented Renal Clearance|Critically Ill Assistance Publique - Hôpitaux de Paris September 3 2020 Not Applicable
NCT04317807 Recruiting Drug: Levetiracetam Pill|Other: Placebo Early Psychosis NYU Langone Health August 1 2020 Phase 2

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