Glycopyrrolate

Catalog No.S4660 Synonyms: Glycopyrrolate bromide, Glycopyrronium bromide, Robinul, Gastrodyn

For research use only.

Glycopyrrolate (Glycopyrronium, Robinul, Gastrodyn) is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.

Glycopyrrolate Chemical Structure

CAS No. 596-51-0

Purity & Quality Control

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Biological Activity

Description Glycopyrrolate (Glycopyrronium, Robinul, Gastrodyn) is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.
Targets
Muscarinic receptor [1]
In vitro

Glycopyrrolate inhibits EFS-induced contraction of guinea-pig trachea and human airways in a concentration-dependent manner. In competition studies, glycopyrrolate binds human peripheral lung and human airway smooth muscle (HASM) muscarinic receptors with affinities in the nanomolar range (Ki values 0.5–3.6 nM). Glycopyrrolate showed no selectivity in its binding to the M1–M3 receptors. Kinetics studies show that glycopyrrolate dissociates slowly from HASM muscarinic receptors[1].

Protocol (from reference)

Solubility (25°C)

In vitro

Water 79 mg/mL
(198.32 mM)
DMSO 65 mg/mL
(163.18 mM)
Ethanol '59 mg/mL

Chemical Information

Molecular Weight 398.33
Formula

C19H28NO3.Br

CAS No. 596-51-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C[N+]1(CCC(C1)OC(=O)C(C2CCCC2)(C3=CC=CC=C3)O)C.[Br-]

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04979039 Recruiting Other: analgesia nociception index (ANI) monitoring Cesarean Section Seoul National University Bundang Hospital August 1 2021 --
NCT04554589 Not yet recruiting Drug: Glycopyrrolate 0.2 MG|Drug: normal saline Effect of Drugs Tanta University September 14 2020 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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