Pramoxine HCl

For research use only.

Catalog No.S4092

1 publication

Pramoxine HCl Chemical Structure

Molecular Weight(MW): 329.86

Pramoxine is a topical local anesthetic that has been shown to have antipruritic properties.

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Selleck's Pramoxine HCl has been cited by 1 publication

1 Customer Review

  • a, Quantification of sterol levels in OPCs (oligodendrocyte progenitor cells) treated with the indicated molecules at 2 μM.

    Nature, 2018, 560(7718):372-376. Pramoxine HCl purchased from Selleck.

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Biological Activity

Description Pramoxine is a topical local anesthetic that has been shown to have antipruritic properties.
In vitro

Pramoxine is used primarily in combination with colloidal oatmeal, hydrocortisone, menthol, and petrolatum. [1]

In vivo Pramoxine (1.7 mM) causes a lower degree of attenuation of the response to substance P than the responses to acetylcholine, histamine and barium chloride on the guinea-pig ileum. Pramoxine exhibits anesthetic inhibitory potency on the guinea-pig ileum with pKa of 6.4. [2] Pramoxine produces shifts in specific skin temperature at which activation and suppression of both panting and shivering occur in dogs, these changes are interpreted as indicating peripheral mediation in control of thermoregulatory end mechanisms. [3]


Solubility (25°C)

In vitro DMSO 66 mg/mL (200.08 mM)
Water 66 mg/mL (200.08 mM)
Ethanol 66 mg/mL (200.08 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 329.86


CAS No. 637-58-1
Storage powder
in solvent
Synonyms N/A

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Dilution Calculator

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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