Pramoxine HCl

For research use only.

Catalog No.S4092

1 publication

Pramoxine HCl Chemical Structure

Molecular Weight(MW): 329.86

Pramoxine is a topical local anesthetic that has been shown to have antipruritic properties.

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USD 97 In stock
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Selleck's Pramoxine HCl has been cited by 1 publication

1 Customer Review

  • a, Quantification of sterol levels in OPCs (oligodendrocyte progenitor cells) treated with the indicated molecules at 2 μM.

    Nature, 2018, 560(7718):372-376. Pramoxine HCl purchased from Selleck.

Purity & Quality Control

Biological Activity

Description Pramoxine is a topical local anesthetic that has been shown to have antipruritic properties.
In vitro

Pramoxine is used primarily in combination with colloidal oatmeal, hydrocortisone, menthol, and petrolatum. [1]

In vivo Pramoxine (1.7 mM) causes a lower degree of attenuation of the response to substance P than the responses to acetylcholine, histamine and barium chloride on the guinea-pig ileum. Pramoxine exhibits anesthetic inhibitory potency on the guinea-pig ileum with pKa of 6.4. [2] Pramoxine produces shifts in specific skin temperature at which activation and suppression of both panting and shivering occur in dogs, these changes are interpreted as indicating peripheral mediation in control of thermoregulatory end mechanisms. [3]

Protocol

Solubility (25°C)

In vitro DMSO 66 mg/mL (200.08 mM)
Water 66 mg/mL (200.08 mM)
Ethanol 66 mg/mL (200.08 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 329.86
Formula

C17H27NO3.HCl

CAS No. 637-58-1
Storage powder
in solvent
Synonyms N/A
Smiles Cl.CCCCOC1=CC=C(OCCCN2CCOCC2)C=C1

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID