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Fudosteine

Cat.No.S2129

Fudosteine is a cysteine derivative and a MUC5AC mucin hypersecretion inhibitor, used as a muco-active agent with indications for chronic respiratory diseases.
Fudosteine Chemical Structure

Chemical Structure

Molecular Weight: 179.24

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Chemical Information, Storage & Stability

Molecular Weight 179.24 Formula

C6H13NO3S

 Storage (From the date of receipt)
CAS No. 13189-98-5 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles C(CO)CSCC(C(=O)O)N

Solubility

In vitro
Batch:

Water : 36 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

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Mass Concentration Volume Molecular Weight

In vivo
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Mechanism of Action

In vitro
Fudosteine (FDS), a unique mucolytic antioxidant, shows a stronger scavenging effect of Peroxynitrite than N-acetyl-cysteine on DCDHF oxidation in vitro and in sputum macrophages, and also on Peroxynitrite-induced BSA nitration. This compound (0.1 mM) reduces Peroxynitrite-enhanced interleukin (IL)-1beta-induced IL-8 release and restores corticosteroid sensitivity defected by Peroxynitrite more potently than those induced by H(2)O(2) in A549 airway epithelial cells. [1] It significantly inhibits increases in GRO/CINC-1 at 10-100 mg/kg, and neutrophils and goblet cells at 30 and 100 mg/kg. This chemical inhibits goblet cell hyperplasia by inhibiting GRO/CINC-1 production and/or neutrophil migration. [2] Its treatment reduces the expression levels of p-p38 MAPK and p-ERK in vivo and of p-ERK in vitro. This agent inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression and the effects of this compound are associated with the inhibition of extracellular signal-related kinase and p38 mitogen-activated protein kinase in vivo and extracellular signal-related kinase in vitro. [3] It significantly suppresses blood flow of tracheal microvasculature increased by SO(2) exposure. This substance scavenges superoxide anion generated from rat neutrophils, and enzymatically generated from xanthine oxidase-acetaldehyde reaction. [4]
In vivo
Fudosteine (500 mg/kg, p.o.) significantly increases the amount of dye excreted into the respiratory tract. This compound increases chloride ion concentration in broncho-alveolar lavage of rats. [5]
References
  • https://pubmed.ncbi.nlm.nih.gov/21782562/
  • https://pubmed.ncbi.nlm.nih.gov/11188505/

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