Fudosteine

For research use only.

Catalog No.S2129

Fudosteine Chemical Structure

Molecular Weight(MW): 179.24

Fudosteine is a cysteine derivative and a MUC5AC mucin hypersecretion inhibitor, used as a muco-active agent with indications for chronic respiratory diseases.

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Biological Activity

Description Fudosteine is a cysteine derivative and a MUC5AC mucin hypersecretion inhibitor, used as a muco-active agent with indications for chronic respiratory diseases.
In vitro

Fudosteine (FDS), a unique mucolytic antioxidant, shows a stronger scavenging effect of Peroxynitrite than N-acetyl-cysteine on DCDHF oxidation in vitro and in sputum macrophages, and also on Peroxynitrite-induced BSA nitration. Fudosteine (0.1 mM) reduces Peroxynitrite-enhanced interleukin (IL)-1beta-induced IL-8 release and restores corticosteroid sensitivity defected by Peroxynitrite more potently than those induced by H(2)O(2) in A549 airway epithelial cells. [1] Fudosteine significantly inhibits increases in GRO/CINC-1 at 10-100 mg/kg, and neutrophils and goblet cells at 30 and 100 mg/kg. Fudosteine inhibits goblet cell hyperplasia by inhibiting GRO/CINC-1 production and/or neutrophil migration. [2] Fudosteine treatment reduces the expression levels of p-p38 MAPK and p-ERK in vivo and of p-ERK in vitro. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression and the effects of fudosteine are associated with the inhibition of extracellular signal-related kinase and p38 mitogen-activated protein kinase in vivo and extracellular signal-related kinase in vitro. [3] Fudosteine significantly suppresses blood flow of tracheal microvasculature increased by SO(2) exposure. Fudosteine scavenges superoxide anion generated from rat neutrophils, and enzymatically generated from xanthine oxidase-acetaldehyde reaction. [4]

In vivo Fudosteine (500 mg/kg, p.o.) significantly increases the amount of dye excreted into the respiratory tract. Fudosteine increases chloride ion concentration in broncho-alveolar lavage of rats. [5]

Protocol

Solubility (25°C)

In vitro Water 36 mg/mL (200.84 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 179.24
Formula

C6H13NO3S

CAS No. 13189-98-5
Storage powder
in solvent
Synonyms N/A
Smiles NC(CSCCCO)C(O)=O

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID