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Fudosteine Mucin chemical

Cat.No.S2129

Fudosteine is a cysteine derivative and a MUC5AC mucin hypersecretion inhibitor, used as a muco-active agent with indications for chronic respiratory diseases.
Fudosteine Mucin chemical Chemical Structure

Chemical Structure

Molecular Weight: 179.24

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Quality Control

Batch: Purity: 99.67%
99.67

Solubility

In vitro
Batch:

Water : 36 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 179.24 Formula

C6H13NO3S

 Storage (From the date of receipt)
CAS No. 13189-98-5 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles C(CO)CSCC(C(=O)O)N

Mechanism of Action

In vitro
Fudosteine (FDS), a unique mucolytic antioxidant, shows a stronger scavenging effect of Peroxynitrite than N-acetyl-cysteine on DCDHF oxidation in vitro and in sputum macrophages, and also on Peroxynitrite-induced BSA nitration. This compound (0.1 mM) reduces Peroxynitrite-enhanced interleukin (IL)-1beta-induced IL-8 release and restores corticosteroid sensitivity defected by Peroxynitrite more potently than those induced by H(2)O(2) in A549 airway epithelial cells. It significantly inhibits increases in GRO/CINC-1 at 10-100 mg/kg, and neutrophils and goblet cells at 30 and 100 mg/kg. This chemical inhibits goblet cell hyperplasia by inhibiting GRO/CINC-1 production and/or neutrophil migration. Its treatment reduces the expression levels of p-p38 MAPK and p-ERK in vivo and of p-ERK in vitro. This agent inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression and the effects of this compound are associated with the inhibition of extracellular signal-related kinase and p38 mitogen-activated protein kinase in vivo and extracellular signal-related kinase in vitro. It significantly suppresses blood flow of tracheal microvasculature increased by SO(2) exposure. This substance scavenges superoxide anion generated from rat neutrophils, and enzymatically generated from xanthine oxidase-acetaldehyde reaction.
In vivo
Fudosteine (500 mg/kg, p.o.) significantly increases the amount of dye excreted into the respiratory tract. This compound increases chloride ion concentration in broncho-alveolar lavage of rats.
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/21782562/
  • [5] https://pubmed.ncbi.nlm.nih.gov/11188505/

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