GO-203

Catalog No.S8674

For research use only.

GO-203 is a D-amino acid cell-penetrating peptide inhibitor of MUC1-C dimerization and thereby its oncogenic function.

GO-203 Chemical Structure

CAS No. 1222186-26-6

Selleck's GO-203 has been cited by 3 Publications

Purity & Quality Control

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Biological Activity

Description GO-203 is a D-amino acid cell-penetrating peptide inhibitor of MUC1-C dimerization and thereby its oncogenic function.
Targets
MUC-1C [1]
()
In vitro

GO-203 inhibits MUC1-C homodimerization which blocks its oncogenic function. Treatment of MUC1-overexpressing SKCO-1 and Colo-205 colon cancer cells with GO-203 is associated with downregulation of the TP53-inducible glycolysis and apoptosis regulator (TIGAR) protein. GO-203 regulates AKT-S6K1-elF4A signaling in colorectal cancer cells. Targeting MUC1-C with GO-203 inhibits p-AKT in colorectal cancer cells. GO-203 treatment also results in increases in reactive oxygen species (ROS) and loss of mitochondrial transmembrane potential[1].

In vivo GO-203 is effective in inhibiting growth and survival of MUC1-positive colorectal cancer cells in mouse xenograft models. It is also effective in xenografts models of breast, prostate, lung and certain hematologic malignancy[1].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: Human SW480 and LOVO colorectal cancer cells
  • Concentrations: 5 μM
  • Incubation Time: 48 h
  • Method:

    To assess cell viability, 20,000–30,000 cells are plated and cultured for 48 h. GO-203 and CP-2 are added at 5 μM every day for six days. Cell viability is measured by trypan blue exclusion.

Animal Research:

[1]

  • Animal Models: BALB/c nu/nu male/female mice with xenograft tumor
  • Dosages: 18 mg/kg
  • Administration: i.p.

Chemical Information

Molecular Weight 2426.77
Formula

C87H170N52O19S2.C2HF3O2

CAS No. 1222186-26-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C(CCN)CC(C(=O)NC(CC(=O)N)C(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CS)NC(=O)C(CCC(=O)N)NC(=O)C(CS)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)N.C(=O)(C(F)(F)F)O

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02204085 Active not recruiting Drug: GO-203-2c|Drug: GO-203-2c + Decitabine Acute Myeloid Leukemia in Relapse|Recurrent Adult Acute Myeloid Leukemia Dana-Farber Cancer Institute September 2014 Phase 1|Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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