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NXY-059 (Disufenton sodium)

Catalog No.S6002 Synonyms: Cerovive, Disufenton Sodium

For research use only.

NXY-059 (Cerovive, Disufenton Sodium) is a novel nitrone, shows efficacious neuroprotective effects. Phase 3.

NXY-059 (Disufenton sodium) Chemical Structure

CAS No. 168021-79-2

Selleck's NXY-059 (Disufenton sodium) has been cited by 1 Publication

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Biological Activity

Description NXY-059 (Cerovive, Disufenton Sodium) is a novel nitrone, shows efficacious neuroprotective effects. Phase 3.
In vitro

NXY-059 is more soluble than the spin trapping agent α-phenyl-N-tert-butyl nitrone (PBN). [1] In an in vitro blood-brain barrier (BBB) model, 250 mM of NXY-059 administered at the onset or up to 4 h after oxygen glucose deprivation (OGD) produces a significant reduction in the increased BBB permeability caused by OGD. Furthermore, OGD produces a huge influx of tissue plasminogen activator across the BBB, which is substantially reduced by NXY-059. [2]
In vivo NXY-059 reduces infarct volume in rats subjected to 2 hours of middle cerebral artery occlusion in a dose-dependent manner. At equimolar doses (3.0 mg/kg for NXY-059 and 1.4 mg/kg for PBN), NXY-059 is more efficacious than PBN. Similar results are obtained when a recovery period of 7 days is allowed. The window of therapeutic opportunity for NXY-059 is 3 to 6 hours after the start of recirculation. [1] NXY-059, a free radical-trapping agent, has a substantial protective effect, lessening the disability caused by an experimentally induced stroke in a primate species. NXY-059 treatment reduces the overall amount of brain damage by >50% of saline-treatment values, with similar levels of protection afforded to both white and gray matter. [3] Treatment with NXY-059 (50 mg/kg subcutaneous plus 8.8 mg/kg/h for 3 days subcutaneous delivered via implanted osmotic pumps) significantly decreases neurological impairment following intracerebral hemorrhage in rat, and reduces the neutrophil infiltrate observed 48 hours post-hemorrhage in the vicinity of the hematoma, and the number of TUNEL-positive cells 48 hours post-hemorrhage at the hematoma margin. [4]

Protocol (from reference)

Animal Research:[1]
  • Animal Models: Monofilament fishing line is used to produce occlusion and neurologic deficit in male Wistar rats
  • Dosages: 0.3, 3.0 or 30 mg/kg
  • Administration: Administered into the right jugular vein.

Solubility (25°C)

In vitro

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.

 30 mg/mL

Chemical Information

Molecular Weight 381.33
Formula

C11H13NNa2O7S2
CAS No. 168021-79-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)(C)[N+](=CC1=C(C=C(C=C1)S(=O)(=O)[O-])S(=O)(=O)[O-])[O-].[Na+].[Na+]

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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