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Technical Data
| Formula | C17H27NO3.HCl |
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| Molecular Weight | 329.86 | CAS No. | 637-58-1 | |
| Solubility (25°C)* | In vitro | DMSO | 66 mg/mL (200.08 mM) | |
| Water | 66 mg/mL (200.08 mM) | |||
| Ethanol | 66 mg/mL (200.08 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Pramoxine(Pramocaine hydrochloride) is a topical local anesthetic that has been shown to have antipruritic properties. |
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| In vitro | Pramoxine is used primarily in combination with colloidal oatmeal, hydrocortisone, menthol, and petrolatum. [1] |
| In vivo | Pramoxine (1.7 mM) causes a lower degree of attenuation of the response to substance P than the responses to acetylcholine, histamine and barium chloride on the guinea-pig ileum. Pramoxine exhibits anesthetic inhibitory potency on the guinea-pig ileum with pKa of 6.4. [2] Pramoxine produces shifts in specific skin temperature at which activation and suppression of both panting and shivering occur in dogs, these changes are interpreted as indicating peripheral mediation in control of thermoregulatory end mechanisms. [3] |
Protocol (from reference)
References
Customer Product Validation
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Data from [Data independently produced by , , Nature, 2018, 560(7718):372-376]
Selleck's Pramoxine HCl has been cited by 1 publication
| Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination [Hubler Z, et al. Nature, 2018, 560(7718):372-376] | PubMed: 30046109 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.