2,2,2-Tribromoethanol

Catalog No.S4508 Synonyms: TBE, Tribromoethanol

For research use only.

2,2,2-Tribromoethanol (TBE, Tribromoethanol) is an organic compound used to anesthetize mice.

2,2,2-Tribromoethanol Chemical Structure

CAS No. 75-80-9

Selleck's 2,2,2-Tribromoethanol has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description 2,2,2-Tribromoethanol (TBE, Tribromoethanol) is an organic compound used to anesthetize mice.
In vivo Tribromoethanol has been proposed as an acceptable anaesthetic in dogs, cats, mice, rats, and gerbils. It possesses a concentration dependent irritant effect. When used at low concentration, it displays good anesthetic effect. A high dose of tribromoethanol is not a suitable anesthetic for major surgery in all mouse strains because of the risk of pathologic changes in the abdominal organs, such as retention of the digestive tract, peritonitis, and fibrinoid adhesion[1][2].

Protocol (from reference)

Animal Research:[2]
  • Animal Models: Male ICR, C57BL/6/Bkl, and BALB/c/Bkl mice
  • Dosages: 200 mg/kg
  • Administration: i.p.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 282.76
Formula

C2H3Br3O

CAS No. 75-80-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C(C(Br)(Br)Br)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04573205 Not yet recruiting Drug: FSME-IMMUN Vaccine Tick-borne Encephalitis|Vaccine Region Örebro County January 2024 Phase 4
NCT05138055 Recruiting Other: No intervention Tick-Borne Encephalitis European Sykehuset Telemark|Sykehuset i Vestfold HF|Norwegian Institute of Public Health|Sorlandet Hospital HF|Oslo University Hospital October 1 2020 --
NCT03932448 Recruiting Other: The proposed study is not interventional. Tick-Bite; Fever|Tick Fever|Tick-Borne Diseases|Encephalitis Tick-Borne|Tick Bites Göteborg University|Sahlgrenska University Hospital Sweden|Vastra Gotaland Region May 15 2019 --
NCT03971058 Unknown status Biological: IXIARO®- Japanese Encephalitis vaccine Japanese Encephalitis Vaccine Medical University of Vienna|Valneva Austria GmbH March 1 2019 Phase 4
NCT03294135 Completed Biological: Encepur Adults Virus Diseases GlaxoSmithKline October 5 2017 Phase 4
NCT04017052 Unknown status Drug: FSME-IMMUN Vaccine Tick Borne Encephalitis Medical University of Vienna April 15 2015 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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