GSK805

Catalog No.S6767 Synonyms: JNJ 56914845, GSK-2336805

For research use only.

GSK805 (JNJ 56914845, GSK-2336805) is a potent and orally bioavailable RORγt inhibitor.

GSK805 Chemical Structure

CAS No. 1426802-50-7

Selleck's GSK805 has been cited by 2 Publications

Purity & Quality Control

Related Other Products

Biological Activity

Description GSK805 (JNJ 56914845, GSK-2336805) is a potent and orally bioavailable RORγt inhibitor.

Protocol (from reference)

Chemical Information

Molecular Weight 532.36
Formula

C23H18Cl2 F3NO4S

 

CAS No. 1426802-50-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCS(=O)(=O)C1=CC=C(C=C1)CC(=O)NC2=CC(=C(C(=C2)Cl)C3=CC=CC=C3OC(F)(F)F)Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01827657 Completed Drug: GSK2336805 Hepatitis C GlaxoSmithKline May 28 2013 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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