Glucosamine hydrochloride

Catalog No.S3694 Synonyms: 2-Amino-2-deoxy-glucose HCl, Chitosamine HCl

For research use only.

Glucosamine (2-Amino-2-deoxy-glucose, Chitosamine) is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, also presents in the shells of shellfish, animal bones, bone marrow, and fungi. Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.

Glucosamine hydrochloride Chemical Structure

CAS No. 66-84-2

Selleck's Glucosamine hydrochloride has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Glucosamine (2-Amino-2-deoxy-glucose, Chitosamine) is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, also presents in the shells of shellfish, animal bones, bone marrow, and fungi. Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.
In vitro

Glucosamine enters the hexosamine biosynthetic pathway (HBP) downstream of the rate-limiting step catalyzed by the GFAT (glutamine:fluctose-6-phosphate amidotransferase), providing UDP-GlcNAc substrates for O-linked β-N-acetylglucosamine (O-GlcNAc) protein modification. Glucosamine inhibits proteasomal activity and the proliferation of ALVA41 prostate cancer cells. The inhibition of proteasomal activity results in the accumulation of ubiquitinated proteins, followed by induction of apoptosis. Glucosamine downregulates proteasome activator PA28γ and overexpression of PA28γ rescues the proteasomal activity and growth inhibition mediated by glucosamine[1]. Glucosamine inhibits the proliferation of RCC cells by promoting cell cycle arrest at G0/G1 phase, but not promoting apoptosis[2].

In vivo Glucosamine could significantly inhibit the production of nitric oxide and prostagladin E2 and suppress the progression of adjuvant arthritis in rats. Glucosamine may be expected as a novel anti-inflammatory agent for treatment of rheumatoid arthritis. Administration of glucosamine normalizes cartilage metabolism, so as to inhibit the degradation and stimulate the synthesis of proteoglycans, and to restore the articular function. Glucosamine has been demonstrated to prolong the allogeneic cardiac allograft survival by repressing the activation of T-lymphoblasts and dendritic cells[3].

Protocol (from reference)

Cell Research:[1]
  • Cell lines: ALVA41 cells
  • Concentrations: 0-2 mM
  • Incubation Time: 24 h
  • Method: ALVA41 cells are treated with various concentrations of glucosamine (GlcN) for 24 h, and cell viability is analyzed using MTT assay.
Animal Research:[3]
  • Animal Models: Male Wistar rats
  • Dosages: 300 mg/kg
  • Administration: oral

Solubility (25°C)

In vitro

Water 43 mg/mL
(199.41 mM)
DMSO 4 mg/mL
(18.55 mM)
Ethanol Insoluble

Chemical Information

Molecular Weight 215.63
Formula

C6H13NO5.HCl

CAS No. 66-84-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C(C1C(C(C(C(O1)O)N)O)O)O.Cl

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