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Glucosamine hydrochloride

Name: Glucosamine hydrochloride
Brand: Selleck Chemicals
SKU: S3694
Rating: 5 (1 reviews)

Synonyms: 2-Amino-2-deoxy-glucose HCl, Chitosamine HCl

Catalog No.S3694 Purity: 98.4%

Glucosamine (2-Amino-2-deoxy-glucose, Chitosamine) is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, also presents in the shells of shellfish, animal bones, bone marrow, and fungi. Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.

Glucosamine hydrochloride Chemical Structure

CAS: 66-84-2

Selleck's Glucosamine hydrochloride has been cited by 1 publication

Purity & Quality Control

Batch: S369401 Water] 43 mg/mL] false] DMSO] 4 mg/mL] false] Ethanol] Insoluble] false Purity: 98.4%

98.4

Glucosamine hydrochloride Related Products

Biological Activity

Description	Glucosamine (2-Amino-2-deoxy-glucose, Chitosamine) is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, also presents in the shells of shellfish, animal bones, bone marrow, and fungi. Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.

In vitro
In vitro	Glucosamine enters the hexosamine biosynthetic pathway (HBP) downstream of the rate-limiting step catalyzed by the GFAT (glutamine:fluctose-6-phosphate amidotransferase), providing UDP-GlcNAc substrates for O-linked β-N-acetylglucosamine (O-GlcNAc) protein modification. Glucosamine inhibits proteasomal activity and the proliferation of ALVA41 prostate cancer cells. The inhibition of proteasomal activity results in the accumulation of ubiquitinated proteins, followed by induction of apoptosis. Glucosamine downregulates proteasome activator PA28γ and overexpression of PA28γ rescues the proteasomal activity and growth inhibition mediated by glucosamine^[1]. Glucosamine inhibits the proliferation of RCC cells by promoting cell cycle arrest at G0/G1 phase, but not promoting apoptosis^[2].
Cell Research	Cell lines	ALVA41 cells
	Concentrations	0-2 mM
	Incubation Time	24 h
	Method	ALVA41 cells are treated with various concentrations of glucosamine (GlcN) for 24 h, and cell viability is analyzed using MTT assay.

In Vivo
In vivo	Glucosamine could significantly inhibit the production of nitric oxide and prostagladin E2 and suppress the progression of adjuvant arthritis in rats. Glucosamine may be expected as a novel anti-inflammatory agent for treatment of rheumatoid arthritis. Administration of glucosamine normalizes cartilage metabolism, so as to inhibit the degradation and stimulate the synthesis of proteoglycans, and to restore the articular function. Glucosamine has been demonstrated to prolong the allogeneic cardiac allograft survival by repressing the activation of T-lymphoblasts and dendritic cells^[3].
Animal Research	Animal Models	Male Wistar rats
	Dosages	300 mg/kg
	Administration	oral

References

Chemical Information & Solubility

Molecular Weight	215.63	Formula	C₆H₁₃NO₅.HCl
CAS No.	66-84-2	SDF	Download Glucosamine hydrochloride SDF
Smiles	C(C1C(C(C(C(O1)O)N)O)O)O.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

Water : 43 mg/mL

DMSO : 4 mg/mL ( (18.55 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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