Home Immunology & Inflammation TLR agonist Polyinosinic acid-polycytidylic acid (Poly(I:C))

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Polyinosinic acid-polycytidylic acid (Poly(I:C)) TLR3 Agonist

Cat.No.E0518

Polyinosinic acid-polycytidylic acid (Polyinosinic-polycytidylic acid; Poly(I:C)), a double-stranded RNA that induces innate immunity in mammals, is a candidate immunopotentiator for pharmaceuticals. Polyinosinic acid-polycytidylic acid is dsRNA formed by the long chain decomposition of muscle poly (I) homopolymer into poly (C) homopolymer.
Polyinosinic acid-polycytidylic acid (Poly(I:C)) TLR agonist Chemical Structure

Chemical Structure

Molecular Weight: 671.40

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Quality Control

Batch: Purity: 99.91%
99.91

Solubility

In vitro
Batch:

Water : 50 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 671.40 Formula

C19H27N7O16P2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 24939-03-5 -- Storage of Stock Solutions

Synonyms Polyinosinic-polycytidylic acid; Poly(I:C) Smiles NC1=NC(=O)N(C=C1)C2OC(CO[P;v5](O)(O)=O)C(O)C2O.OC3C(O)C(OC3CO[P;v5](O)(O)=O)[N]4C=NC5=C4NC=NC5=O

Mechanism of Action

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02423863 Completed
Melanoma|Head and Neck Cancer|Sarcoma|Non-Melanoma Skin Cancers
Oncovir Inc.|National Institutes of Health (NIH)|Icahn School of Medicine at Mount Sinai|Bay Hematology Oncology|National Cancer Institute (NCI)|University of Missouri-Columbia|Chevy Chase Regional Cancer Care Associates LLC|Dermatologic Surgery Center of Washington LLC and Skin Cancer Treatment Center
 March 2015 Phase 2
NCT01727895 Completed
Immunologic Deficiency Syndromes
Radboud University Medical Center
 May 2013 Not Applicable

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