- Inhibitory Selectivity
|Catalog No.||Product Name||Solubility(25°C)|
|S1324||Doxazosin Mesylate||<1 mg/mL||15 mg/mL||<1 mg/mL|
|S5739||Nebivolol||-1 mg/mL||88 mg/mL||-1 mg/mL|
|S5088||Labetalone hydrochloride||-1 mg/mL||72 mg/mL||-1 mg/mL|
|S4076||Propranolol HCl||6 mg/mL||59 mg/mL||<1 mg/mL|
|S1206||Bisoprolol fumarate||88 mg/mL||88 mg/mL||88 mg/mL|
|S4113||Desvenlafaxine||<1 mg/mL||37 mg/mL||3 mg/mL|
|S1642||Methyldopa||<1 mg/mL||2 mg/mL||<1 mg/mL|
|S4112||Desvenlafaxine Succinate||<1 mg/mL||80 mg/mL||<1 mg/mL|
|S2086||Ivabradine HCl||82 mg/mL||101 mg/mL||101 mg/mL|
|S2113||Cisatracurium Besylate||47 mg/mL||249 mg/mL||249 mg/mL|
|S1283||Asenapine maleate||<1 mg/mL||80 mg/mL||<1 mg/mL|
|S5666||Moxisylyte hydrochloride||-1 mg/mL||63 mg/mL||-1 mg/mL|
|S5540||Landiolol hydrochloride||100 mg/mL||100 mg/mL||42 mg/mL|
|S5341||Metroprolol succinate||100 mg/mL||100 mg/mL||5 mg/mL|
|S5430||Metoprolol||-1 mg/mL||53 mg/mL||-1 mg/mL|
|S5281||Dapiprazole Hydrochloride||72 mg/mL||21 mg/mL||72 mg/mL|
|S5432||Dibenamine Hydrochloride||-1 mg/mL||59 mg/mL||-1 mg/mL|
|S5337||Rauwolscine hydrochloride||-1 mg/mL||7 mg/mL||-1 mg/mL|
|S5042||Bevantolol hydrochloride||52 mg/mL||76 mg/mL||61 mg/mL|
|S4817||Atenolol||35 mg/mL||53 mg/mL||53 mg/mL|
|S1409||Alfuzosin HCl||85 mg/mL||85 mg/mL||85 mg/mL|
|S1613||Silodosin||<1 mg/mL||99 mg/mL||99 mg/mL|
|S1549||Nebivolol HCl||<1 mg/mL||88 mg/mL||<1 mg/mL|
|S2691||BMY 7378 Dihydrochloride||92 mg/mL||92 mg/mL||20 mg/mL|
|S1424||Prazosin HCl||<1 mg/mL||4 mg/mL||<1 mg/mL|
|S2038||Phentolamine Mesylate||76 mg/mL||76 mg/mL||76 mg/mL|
|S1856||Metoprolol Tartrate||100 mg/mL||100 mg/mL||31 mg/mL|
|S2059||Terazosin HCl Dihydrate||<1 mg/mL||26 mg/mL||<1 mg/mL|
|S1387||Naftopidil DiHCl||<1 mg/mL||41 mg/mL||2 mg/mL|
|S2517||Maprotiline HCl||<1 mg/mL||63 mg/mL||24 mg/mL|
|S1831||Carvedilol||<1 mg/mL||81 mg/mL||4 mg/mL|
|S2126||Naftopidil||<1 mg/mL||79 mg/mL||<1 mg/mL|
|S2499||Phenoxybenzamine HCl||17 mg/mL||68 mg/mL||68 mg/mL|
|S2509||Sotalol HCl||61 mg/mL||61 mg/mL||<1 mg/mL|
|S4123||Timolol Maleate||<1 mg/mL||86 mg/mL||86 mg/mL|
|S4010||Acebutolol HCl||75 mg/mL||75 mg/mL||75 mg/mL|
|S1827||Betaxolol HCl||69 mg/mL||69 mg/mL||69 mg/mL|
|S2607||Buflomedil HCl||69 mg/mL||31 mg/mL||7 mg/mL|
|S4729||Tamsulosin hydrochloride||17 mg/mL||88 mg/mL||8 mg/mL|
|S4124||Tolazoline HCl||39 mg/mL||39 mg/mL||39 mg/mL|
|S4649||Atipamezole hydrochloride||21 mg/mL||12 mg/mL||49 mg/mL|
|S4650||Atipamezole||<1 mg/mL||42 mg/mL||42 mg/mL|
|S3656||Piribedil||<1 mg/mL||59 mg/mL||59 mg/mL|
|S4679||Terazosin HCl||1 mg/mL||84 mg/mL||<1 mg/mL|
|S4085||Levobetaxolol HCl||69 mg/mL||69 mg/mL||69 mg/mL|
|S8114||ICI-118551 Hydrochloride||21 mg/mL||62 mg/mL||62 mg/mL|
|S4100||Esmolol HCl||66 mg/mL||66 mg/mL||66 mg/mL|
|S2091||Betaxolol||62 mg/mL||62 mg/mL||<1 mg/mL|
|S4278||Carteolol HCl||65 mg/mL||65 mg/mL||<1 mg/mL|
|S2373||Yohimbine HCl||<1 mg/mL||12 mg/mL||<1 mg/mL|
|S4291||Labetalol HCl||8 mg/mL||72 mg/mL||7 mg/mL|
|S2507||Salbutamol Sulfate||68 mg/mL||<1 mg/mL||<1 mg/mL|
|S4009||Mirabegron||<1 mg/mL||79 mg/mL||8 mg/mL|
|S2516||Xylazine HCl||12 mg/mL||50 mg/mL||50 mg/mL|
|S5683||Isoproterenol sulfate dihydrate||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S5564||Xylazine||-1 mg/mL||44 mg/mL||-1 mg/mL|
|S5734||Midodrine hydrochloride||58 mg/mL|
|S5217||Arformoterol Tartrate||-1 mg/mL||99 mg/mL||-1 mg/mL|
|S5654||Indacaterol||<1 mg/mL||52 mg/mL||20 mg/mL|
|S5267||Nylidrin Hydrochloride||67 mg/mL||2 mg/mL|
|S5537||Tizanidine||15 mg/mL||50 mg/mL||6 mg/mL|
|S5494||Salbutamol||-1 mg/mL||47 mg/mL||-1 mg/mL|
|S5527||Salmeterol||<1 mg/mL||83 mg/mL||83 mg/mL|
|S3960||Higenamine hydrochloride||-1 mg/mL||61 mg/mL||-1 mg/mL|
|S3643||Amitraz||<1 mg/mL||58 mg/mL||<1 mg/mL|
|S3664||Flupenthixol dihydrochloride||100 mg/mL||100 mg/mL||30 mg/mL|
|S3083||Indacaterol Maleate||<1 mg/mL||102 mg/mL||<1 mg/mL|
|S2566||Isoprenaline HCl||50 mg/mL||50 mg/mL||<1 mg/mL|
|S2020||Formoterol Hemifumarate||<1 mg/mL||80 mg/mL||<1 mg/mL|
|S2521||Epinephrine bitartrate||67 mg/mL||67 mg/mL||<1 mg/mL|
|S2458||Clonidine HCl||53 mg/mL||53 mg/mL||53 mg/mL|
|S3041||Droxidopa||<1 mg/mL||<1 mg/mL||<1 mg/mL|
|S3075||Dexmedetomidine||<1 mg/mL||40 mg/mL||40 mg/mL|
|S2522||L-Adrenaline||<1 mg/mL||4 mg/mL||<1 mg/mL|
|S2569||Phenylephrine HCl||41 mg/mL||41 mg/mL||41 mg/mL|
|S4065||Guanabenz Acetate||<1 mg/mL||58 mg/mL||5 mg/mL|
|S2519||Naphazoline HCl||49 mg/mL||17 mg/mL||22 mg/mL|
|S2533||Ritodrine HCl||65 mg/mL||65 mg/mL||65 mg/mL|
|S2438||Synephrine HCl||41 mg/mL||14 mg/mL||4 mg/mL|
|S2090||Dexmedetomidine HCl||<1 mg/mL||48 mg/mL||48 mg/mL|
|S3061||Epinephrine HCl||44 mg/mL||44 mg/mL||7 mg/mL|
|S3060||Medetomidine HCl||47 mg/mL||12 mg/mL||47 mg/mL|
|S1437||Tizanidine HCl||15 mg/mL||10 mg/mL||<1 mg/mL|
|S2092||Detomidine HCl||45 mg/mL||45 mg/mL||45 mg/mL|
|S2545||Scopine||<1 mg/mL||31 mg/mL||<1 mg/mL|
|S4296||Salmeterol Xinafoate||<1 mg/mL||100 mg/mL||4 mg/mL|
|S2523||DL-Adrenaline||<1 mg/mL||0.02 mg/mL||<1 mg/mL|
|S4266||Brimonidine Tartrate||75 mg/mL||88 mg/mL||<1 mg/mL|
|S2615||Noradrenaline bitartrate monohydrate||64 mg/mL||64 mg/mL||<1 mg/mL|
|S7974||L755507||<1 mg/mL||100 mg/mL||<1 mg/mL|
|S4127||Terbutaline Sulfate||100 mg/mL||<1 mg/mL||<1 mg/mL|
|S4135||Clorprenaline HCl||50 mg/mL||50 mg/mL||50 mg/mL|
|S4043||Tetrahydrozoline HCl||47 mg/mL||12 mg/mL||26 mg/mL|
|S2576||Xylometazoline HCl||56 mg/mL||27 mg/mL||56 mg/mL|
|S3640||Methoxyphenamine Hydrochloride||43 mg/mL||43 mg/mL||43 mg/mL|
|S3727||Vilanterol Trifenate||<1 mg/mL||100 mg/mL||14 mg/mL|
|S4693||Guanfacine Hydrochloride||30 mg/mL||56 mg/mL||56 mg/mL|
|S4277||Bambuterol HCl||72 mg/mL||80 mg/mL||28 mg/mL|
|S2362||Synephrine||<1 mg/mL||33 mg/mL||2 mg/mL|
|S3185||Adrenalone HCl||44 mg/mL||44 mg/mL||<1 mg/mL|
|S4243||Deoxycorticosterone acetate||<1 mg/mL||11 mg/mL||6 mg/mL|
- Adrenergic Receptor Inhibitors (109)
- New Adrenergic Receptor Products
|Catalog No.||Information||Product Use Citations||Product Validations|
Doxazosin, a quinazoline-derivative, selectively antagonizes postsynaptic α1-adrenergic receptors, used in the treatment of high blood pressure and urinary retention associated with benign prostatic hyperplasia.
Nebivolol is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.
Labetalone hydrochloride is hydrochloride form of labetalone, a blocker of both alpha- and beta-adrenergic receptors that is used as an antihypertensive.
Propranolol HCl is a competitive non-selective beta-adrenergic receptors inhibitor with IC50 of 12 nM.
Bisoprolol fumarate is a selective type β1 adrenergic receptor blocker.
Desvenlafaxine is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively.
Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.
Desvenlafaxine Succinate is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively.
Ivabradine HCl, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.
Cisatracurium Besylate is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.
Asenapine maleate is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder.
Moxisylyte hydrochloride is an alpha-adrenergic blocking agent used for the treatment of Raynaud's disease.
Fargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway.
Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects.
Landiolol hydrochloride is the hydrochloride salt form of Landiolol, which is an ultra-short-acting β1 selective adrenoceptor antagonist.
Metoprolol Succinate is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity.
Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension.
Dapiprazole Hydrochloride is the hydrochloride salt form of dapiprazole, an alpha-adrenergic blocker used to reverse mydriasis after eye examination.
Dibenamine is an irreversible blocker of α1 adrenoceptors.
Rauwolscine hydrochloride is the hydrochloride salt form of Rauwolscine, a specific and potent α2 antagonist with Ki of 12 nM.
Bevantolol hydrochloride is a cardioselective, beta adrenoceptor antagonist, devoid of intrinsic β sympathomimetic activity and with weak membrane-stabilizing and local anesthetic properties.
Atenolol is a selective β1 receptor antagonist with log Kd values of −6.66±0.05, −5.99±0.14, −4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors.
Alfuzosin HCl is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).
PC-3 and LNCaP cell viability following treatment with a1-adrenoceptor antagonists. (A) Cells were treated with drug (0.01-100 μM) for 72 hr and cell viability determined using the resazurin reduction assay. (B) Effect of treatment duration on PC-3 and LNCap cell survival following treatment with doxazosin (30 μM) or prazosin (30 μM). Survival is expressed as the percentage values of untreated vehicle control and values are the mean ( sem) of six independent determinations each conducted in triplicate. *P<0.05, ***P<0.001 compared to corresponding values for LNCap cells.
Silodosin is a highly selective α1A-adrenoceptor antagonist, used in treatment of benign prostatic hyperplasia.
Nebivolol HCl selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM.
BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3.
Prazosin HCl is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia.
Phentolamine Mesylate is a reversible and nonselective alpha-adrenergic receptor antagonist, used for the prevention or control of hypertensive episodes.
Metoprolol Tartrate is a selective β1 receptor blocker medication, used to treat hypertension and heart failure.
Terazosin HCl is a selective α1-adrenoceptor antagonist, used for treatment of symptoms of an enlarged prostate (BPH).
Naftopidil DiHCl is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively.
Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression.
Carvedilol is a non-selective beta blocker/alpha-1 blocker, used to treat congestive heart failure (CHF) and high blood pressure.
Naftopidil is a selective α1-adrenergic receptor antagonist with Ki of 3.7 nM, 20 nM, and 1.2 nM for α1a, α1b, and α1d, respectively, used for the treatment of benign prostatic hyperplasia.
Phenoxybenzamine HCl is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM.
Sotalol is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM.
Timolol Maleate is a non-selective, beta-adrenergic receptor antagonist for β1/β2 with Ki of 1.97 nM/2.0 nM.
Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.
Betaxolol is a β1 adrenergic receptor blocker with IC50 of 6 μM.
Buflomedil HCl is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease; A nonselective alpha adrenergic receptor inhibitor.
Tamsulosin is a potent and selective α1a adrenergic receptor antagonist with Ki values of 0.13 nM, 1.92 nM and 0.18 nM for α1a-AR, α1b-AR and α1d-AR.
The presence of autophagosomes was visualized by fluorescent microscopy. (Cytotoxicity, caspase-3 activity and autophagy induced by treatment of PC-3 and LNCap cells with prazosin or doxazosin for 24 hr)
Tolazoline is a non-selective competitive α-adrenergic receptor antagonist.
Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. Atipamezole hydrochloride is hydrochloride form of atipamezole.
Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug.
Piribedil is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.
Terazosin is a selective alpha-1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.
Levobetaxolol exhibits a higher affinity at cloned human β1 and β2 receptors with Ki value of 0.76 nM and 32.6 nM, respectively.
ICI-118551 is a highly selective β2-adrenergic receptor antagonist with Ki values of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively.
Esmolol is a cardioselective b-blocker, used to control rapid heartbeats or abnormal heart rhythms.
Betaxolol is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.
Carteolol HCl is a β-adrenoceptor antagonist, used for the treatment of glaucoma.
Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.
Labetalol HCl is a dual antagonist for both selective alpha1-adrenergic and nonselective beta-adrenergic receptors, used in the treatment of high blood pressure.
Salbutamol Sulfate is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM.
(B) Bar graphs summarize the incidence of VA from Con (An external file that holds a picture, illustration, etc. Object name is srep07681-m1.jpg) and HF (An external file that holds a picture, illustration, etc. Object name is srep07681-m2.jpg) guinea pigs before and after administration of Sal (10 μM) or Sal plus ICI (1 μM) (*p < 0.05, HF + Sal vs. Con + Sal; #p < 0.05, HF + Sal vs. HF + Sal + ICI, n = 6).
Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.
Xylazine is an α2-Adrenergic receptor agonist, used as a sedative and muscle relaxant.
Isoproterenol Sulfate is the sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity.
Norepinephrine is the neurotransmitter at most sympathetic neuroeffector junctions and has pharmacologic effects on both α1 and β1 adrenoceptors.
Dihydroergotamine Mesylate is an ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors.
(−)-Norepinephrine is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.
Brimonidine is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure.
Xylazine is a partial alpha-2 adrenergic agonist that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals.
Tetryzoline is an alpha-adrenergic agonist used in some over-the-counter eye drops and nasal sprays.
Midodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor.
Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist.
Arformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity.
Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.
Nylidrin Hydrochloride, a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well.
Tizanidine is an imidazoline derivative and a centrally acting α2 adrenergic agonist used as a muscle relaxant for therapy of acute muscle spasms and chronic spasticity.
Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases.
Salmeterol is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500).
Higenamine, also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.
Amitraz is a triazapentadiene, an α2 adrenergic agonist and a member of the amidine chemical family. It is a non-systemic acaricide and insecticide.
Flupentixol, an antipsychotic neuroleptic drug, is a powerful antagonist of both D1 and D2 dopamine receptors and also an alpha-adrenergic receptor antagonist.
Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.
Isoprenaline is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block.
Formoterol Hemifumarate is a potent, selective and long-acting β2-adrenoceptor agonist used in the management of asthma and chronic obstructive pulmonary disease(COPD).
Epinephrine bitartrate is an alpha- and beta-adrenergic receptor stimulator.
Clonidine HCl is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.
Droxidopa is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).
Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.
L-Adrenaline belongs to a group of the compounds known as catecholamines.
Phenylephrine HCl is a selective α1-adrenergic receptor agonist, used primarily as a decongestant.
(F) Fluo-4 AM-loaded EPLC-SMCs and HCASMCs displayed a change in cell surface area following phenylephrine stimulation. Scale bars, 100 μm. (G) Percentage change in cell surface area. Error bars represent SEM; n = 12 cells; **p < 0.01 versus D15 + 8 + 6 cells that did not exhibit calcium transients, analyzed by the Student's t-test. HCASMCs, human coronary artery smooth muscle cells; NS, no significant difference.
Guanabenz Acetate is an selective agonist of α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor with pEC50 of 8.25, 7.01 and ~5, respectively.
Naphazoline HCl is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.
Ritodrine HCl is a hydrochloride salt of ritodrine which is a β-2 adrenergic receptor agonist.
SynephrineHCl (Oxedrine, p-Synephrine) is a sympathomimetic α-adrenergic receptor (AR) agonist.
Dexmedetomidine HCl is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation.
Epinephrine HCl is a hormone and a neurotransmitter.
Medetomidine is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor.
Tizanidine HCl is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.
Detomidine HCl produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors.
Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.
Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms.
DL-Adrenaline is a hormone and a neurotransmitter secreted by the medulla of the adrenal glands.
Brimonidine Tartrate is a highly selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma or ocular hypertension.
Noradrenaline bitartrate monohydrate is a direct alpha-adrenergic receptors stimulator.
L-755,507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.
Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.
Clorprenaline HCl is a β2-receptor agonist, it has a significant expansion of the bronchial effect.
Tetrahydrozoline HCl is an imidazoline derivative with alpha receptor agonist activity.
Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM.
Methoxyphenamine Hydrochloride is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator.
Vilanterol trifenatate is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma.
Guanfacine Hydrochloride is a selective α2A-adrenoceptor agonist with anti-hypertensive effect.
Bambuterol HCl is a potent β-adrenoceptor agonist, used in the treatment of asthma.
Synephrine, a natural protoalkaloid in the extract of bitter orange and other citrus species, is commonly used for weight loss.
Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors.
Deoxycorticosterone acetate is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.