S1206 |
Bisoprolol fumarate
|
Bisoprolol fumarate (EMD33512) is a selective type β1 adrenergic receptor blocker. |
-
Sci Rep, 2019, 9(1):3018
-
J Chromatogr B Analyt Technol Biomed Life Sci, 2019, 1129:121793
-
J Cell Mol Med, 2018, 22(12):5964-5977
|
|
S1324 |
Doxazosin Mesylate
|
Doxazosin, a quinazoline-derivative, selectively antagonizes postsynaptic α1-adrenergic receptors, used in the treatment of high blood pressure and urinary retention associated with benign prostatic hyperplasia. |
-
J Ocul Pharmacol Ther, 2017, 33(1):50-56
-
Prostate, 2016, 76(8):757-66
-
Antiviral Res, 2015, 120:140-6
|
|
S1642 |
Methyldopa
|
Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg. |
|
|
S2086 |
Ivabradine HCl
|
Ivabradine HCl (S 16257-2), a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent. |
-
Cell Rep, 2022, 38(10):110468
-
J Pain, 2018, 19(6):626-634
|
|
S2113 |
Cisatracurium Besylate
|
Cisatracurium Besylate is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission. |
-
Biosci Trends, 2021, 15(1):50-54
|
|
S3913 |
Pimethixene maleate
|
Pimethixene (Pimetixene) maleate, an antihistamine, anntimigraine agent and antiserotonergic compound, is a highly potent antagonist of a broad range of monoamine receptors, including a variety of serotonin receptors. Pimethixene maleate inhibits 5-HT2A, 5-HT2B, 5-HT2C, 5-HT1A, 5-HT1B, 5-HT6, 5-HT7, Adrenergic α-1A, Dopamine D1 Receptor, Dopamine D2 Receptor, Dopamine D4.4 Receptor, Histamine H1 Receptor, Muscarinic M1 and Muscarinic M2 with pKi of 10.22, 10.44, 8.42, 7.63, < 5, 7.30, 7.28, 7.61, 6.37, 8.19, 7.54, 10.14, 8.61 and 9.38, respectively. |
|
|
S4076 |
Propranolol HCl
|
Propranolol HCl (AY-64043, ICI-45520, NCS-91523) is a competitive non-selective beta-adrenergic receptors inhibitor with IC50 of 12 nM. |
-
Cell Rep, 2022, 38(10):110468
-
Cancers (Basel), 2022, 14(9)2222
-
Cell Death Discov, 2022, 8(1):36
|
|
S4112 |
Desvenlafaxine Succinate
|
Desvenlafaxine Succinate (WY 45233) is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively. |
-
Drug Metab Dispos, 2020, 48(10):1044-1052
|
|
S4113 |
Desvenlafaxine
|
Desvenlafaxine (WY 45233 Succinate) is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively. |
-
Drug Metab Dispos, 2020, 48(10):1044-1052
|
|
S5088 |
Labetalone hydrochloride
|
Labetalone hydrochloride (Benzoic amide) is hydrochloride form of labetalone, a blocker of both alpha- and beta-adrenergic receptors that is used as an antihypertensive. |
|
|
S5703 |
Carvedilol Phosphate
|
Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity. |
-
Res Pharm Sci, 2016, 11(5):419-427
-
Res Pharm Sci, 2015, 10(5):388-96
|
|
S5723 |
Carvedilol EP IMpurity E
|
Carvedilol is a nonselective beta blocker/alpha-1 blocker and used in management of congestive heart failure (CHF). |
|
|
S5739 |
Nebivolol
|
Nebivolol (Bystolic) is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure. |
-
Front Pharmacol, 2021, 12:691998
-
Sci Rep, 2015, 5:16406
|
|
S5787 |
Dronedarone
|
Dronedarone (SR33589) is a derivative of amiodarone which is classified as a Class III antiarrhythmic agent. It shows rate-dependent inhibition of the rapid Na+ current, inhibits α and β-adrenergic receptors like Class II agents, exhibits blockade of K+ outward currents as the main mechanism of action of Class III, and effectively block slow Ca2+ inward currents (Class IV). |
-
Chem Res Toxicol, 2021, 10.1021/acs.chemrestox.1c00127
|
|
S6345 |
3-Nitro-L-tyrosine
|
3-Nitro-L-tyrosine (3-NT, N-Tyr, MNT), synthesized from L-tyrosine by peroxynitrite, is a product of nitric oxide and superoxide. 3-Nitro-L-tyrosine inhibits the hemodynamic responses to angiotensin II, possibly through the inhibition of alpha 1-adrenoceptor-mediated events. |
|
|
S9560 |
Anisodamine Hydrobromide
|
Anisodamine (6-Hydroxyhyoscyamine) is a naturally occurring atropine derivative and exhibits anti-inflammatory activity. It also inhibits α1-adrenergic receptors and muscarinic acetylcholine receptors (mAChRs). |
|
|
S3764 |
Isoferulic Acid
|
Isoferulic acid (Hesperetic acid, Hesperetate, Isoferulate), a major active ingredient of Cimicifuga heracleifolia, shows anti-inflammatory, antiviral, antioxidant, and antidiabetic properties. Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) is a cinnamic acid derivative that has antidiabetic activity. Isoferulic acid binds to and activates α1-adrenergic receptors (IC50=1.4 µM) to enhance secretion of β-endorphin (EC50=52.2 nM) and increase glucose use. |
|
|
S0116 |
Piperoxan hydrochloride
|
Piperoxan hydrochloride (Benodaine, Fourneau 933, F933, DL-Piperoxan) is an antagonist of α2 (alpha 2) adrenoceptor. |
|
|
S0812 |
SR59230A
|
SR59230A is a blood-brain barrier penetrating, potent and selective antagonist of β3-adrenergic receptor with IC50 of 40 nM, 408 nM, and 648 nM for β3, β1, and β2 receptors, respectively. |
|
|
S0862 |
L-765314
|
L-765314 is a selective and potent α1b-adrenoceptor (α1b adrenergic receptor) antagonist with an IC50 of 1.90 nM and Kis of 5.4 and 2.0 for rat and human α1b adrenergic receptor, respectively. |
|
|
S1283 |
Asenapine maleate
|
Asenapine maleate (Org 5222) is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder. |
-
Biochem Biophys Res Commun, 2021, 553:172-179
-
Anticancer Res, 2021, 41(2):687-697
-
Sci Rep, 2018, 8(1):15753
|
|
S1387 |
Naftopidil DiHCl
|
Naftopidil DiHCl (KT-611) is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively. |
|
|
S1409 |
Alfuzosin HCl
|
Alfuzosin HCl is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH). |
-
Prostate, 2016, 76(8):757-66
|
|
S1424 |
Prazosin HCl
|
Prazosin HCl (cp-12299-1) is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia. |
-
BMC Pharmacol Toxicol, 2020, 21(1):61
|
|
S1435 |
Tamsulosin hydrochloride
|
Tamsulosin (Flomax) hydrochloride is an antagonist of alpha1A adrenoceptors in the prostate. |
|
|
S1549 |
Nebivolol hydrochloride (R-65824)
|
Nebivolol HCl (R-65824) selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM. |
-
Oncogenesis, 2022, 11(1):24
-
Nat Commun, 2021, 12(1):5919
-
Front Pharmacol, 2021, 12:691998
|
|
S1613 |
Silodosin
|
Silodosin (KAD 3213, KMD 3213) is a highly selective α1A-adrenoceptor antagonist, used in treatment of benign prostatic hyperplasia. |
|
|
S1827 |
Betaxolol HCl
|
Betaxolol (SL 75212) is a β1 adrenergic receptor blocker with IC50 of 6 μM. |
-
Chirality, 2018, 30(11):1195-1205
|
|
S1831 |
Carvedilol
|
Carvedilol (BM-14190, SKF 105517) is a non-selective beta blocker/alpha-1 blocker, used to treat congestive heart failure (CHF) and high blood pressure. |
-
PLoS Pathog, 2020, 16;16(3):e1008341
-
Res Pharm Sci, 2016, 11(5):419-427
-
Res Pharm Sci, 2015, 10(5):388-96
|
|
S1856 |
Metoprolol Tartrate
|
Metoprolol Tartrate (CGP 2175E) is a selective β1 receptor blocker medication, used to treat hypertension and heart failure. |
|
|
S2038 |
Phentolamine Mesylate
|
Phentolamine Mesylate is a reversible and nonselective alpha-adrenergic receptor antagonist, used for the prevention or control of hypertensive episodes. |
-
Oncol Rep, 2021, 46(3)202
|
|
S2059 |
Terazosin HCl Dihydrate
|
Terazosin HCl is a selective α1-adrenoceptor antagonist, used for treatment of symptoms of an enlarged prostate (BPH). |
-
J Biomed Sci, 2021, 28(1):8
|
|
S2091 |
Betaxolol
|
Betaxolol (SL 75212) is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma. |
-
Nat Commun, 2020, 24;11(1):1990
-
Chirality, 2018, 30(11):1195-1205
|
|
S2126 |
Naftopidil
|
Naftopidil (KT-611) is a selective α1-adrenergic receptor antagonist with Ki of 3.7 nM, 20 nM, and 1.2 nM for α1a, α1b, and α1d, respectively, used for the treatment of benign prostatic hyperplasia. |
-
Cell Syst, 2019, 8(2):97-108
|
|
S2174New |
Hydroxyflutamide (Hydroxyniphtholide)
|
Hydroxyflutamide (SCH-16423, Hydroxyniphtholide) is an androgen receptor (AR) antagonist and possesses an IC50 of 0.7 μM for the androgen receptor.
|
|
|
S2373 |
Yohimbine HCl
|
Yohimbine (Antagonil) has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac. |
-
J Med Chem, 2021, 64(18):13510-13523
-
J Inflamm Res, 2021, 14:1217-1233
-
J Med Virol, 2019, 91(8):1440-1447
|
|
S2499 |
Phenoxybenzamine HCl
|
Phenoxybenzamine HCl (NSC 37448, NCI-c01661) is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM. |
|
|
S2509 |
Sotalol HCl
|
Sotalol is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM. |
-
Toxicol Appl Pharmacol, 2021, 431:115731
-
Gynecol Oncol, 2018, 151(3):525-532
-
Toxicol Appl Pharmacol, 2015, 285(1):51-60
|
|
S2517 |
Maprotiline HCl
|
Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression. |
-
Front Pharmacol, 2021, 12:689767
|
|
S2607 |
Buflomedil HCl
|
Buflomedil HCl is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease; A nonselective alpha adrenergic receptor inhibitor. |
|
|
S2691 |
BMY 7378 Dihydrochloride
|
BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3. |
|
|
S3656 |
Piribedil
|
Piribedil (Trivastal, Trivastan) is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties. |
|
|
S3664 |
Flupentixol dihydrochloride
|
Flupentixol (Flupenthixol) dihydrochloride, an antipsychotic neuroleptic drug, is a powerful antagonist of both D1 and D2 dopamine receptors and also an alpha-adrenergic receptor antagonist. |
|
|
S4010 |
Acebutolol HCl
|
Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias. |
-
Front Pharmacol, 2021, 12:740529
|
|
S4085 |
Levobetaxolol HCl
|
Levobetaxolol (AL 1577A) exhibits a higher affinity at cloned human β1 and β2 receptors with Ki value of 0.76 nM and 32.6 nM, respectively. |
|
|
S4100 |
Esmolol HCl
|
Esmolol (ASL8052) is a cardioselective b-blocker, used to control rapid heartbeats or abnormal heart rhythms. |
|
|
S4123 |
Timolol Maleate
|
Timolol Maleate (MK-950) is a non-selective, beta-adrenergic receptor antagonist for β1/β2 with Ki of 1.97 nM/2.0 nM. |
-
J Dermatolog Treat, 2020, 24:1-7
|
|
S4124 |
Tolazoline HCl
|
Tolazoline is a non-selective competitive α-adrenergic receptor antagonist. |
-
Insect Biochem Mol Biol, 2017, 90:61-70
|
|
S4278 |
Carteolol HCl
|
Carteolol HCl is a β-adrenoceptor antagonist, used for the treatment of glaucoma.
|
|
|
S4291 |
Labetalol HCl
|
Labetalol HCl is a dual antagonist for both selective alpha1-adrenergic and nonselective beta-adrenergic receptors, used in the treatment of high blood pressure.
|
|
|
S4358 |
Pimozide
|
Pimozide (Orap, R6238) is an antagonist of Dopamine Receptors with Ki of 0.83 nM, 3.0 nM and 6600 nM for dopamine D3, D2 and D1 receptors, respectively. Pimozide also exhibits binding affinity at α2-adrenoceptor and 5-HT1A with Ki of 360 nM and 310 nM, respectively. Pimozide is an antipsychotic drug with anti-tumor activity and suppresses STAT3 and STAT5 activity. |
-
Biol Pharm Bull, 2021, 10.1248/bpb.b21-00531
|
|
S4649 |
Atipamezole hydrochloride
|
Atipamezole (Antisedan, MPV1248) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. Atipamezole hydrochloride is hydrochloride form of atipamezole. |
|
|
S4650 |
Atipamezole
|
Atipamezole (MPV-1248, MPV1248, Antisedan) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. |
-
Exp Mol Med, 2020, 10.1038/s12276-020-0461-6
-
Nitric Oxide, 2019, 85:1-9
-
Front Neurol, 2019, 10:1041
|
|
S4679 |
Terazosin HCl
|
Terazosin (Hytrin, Zayasel, Terazosine, Flumarc, Fosfomic, Blavin) is a selective alpha-1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls. |
-
J Biomed Sci, 2021, 28(1):8
|
|
S4797 |
Nicergoline
|
Nicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins. It has a selective alpha-1A adrenergic receptor blocking property and also other additional mechanisms of actions. |
|
|
S4817 |
Atenolol
|
Atenolol (Tenormin, Normiten, Blokium) is a selective β1 receptor antagonist with log Kd values of −6.66±0.05, −5.99±0.14, −4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors. |
-
Oncol Rep, 2021, 46(3)202
|
|
S5023 |
Nadolol
|
Nadolol (Corgard, Solgol, Anabet, SQ11725) is a non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities. |
|
|
S5042 |
Bevantolol hydrochloride
|
Bevantolol hydrochloride (NC-1400) is a cardioselective, beta adrenoceptor antagonist, devoid of intrinsic β sympathomimetic activity and with weak membrane-stabilizing and local anesthetic properties. |
|
|
S5281 |
Dapiprazole Hydrochloride
|
Dapiprazole Hydrochloride (Glamidolo Hydrochloride, Reversil Hydrochloride) is the hydrochloride salt form of dapiprazole, an alpha-adrenergic blocker used to reverse mydriasis after eye examination. |
|
|
S5337 |
Rauwolscine hydrochloride
|
Rauwolscine hydrochloride (Isoyohimbine, α-Yohimbine, corynanthidine) is the hydrochloride salt form of Rauwolscine, a specific and potent α2 antagonist with Ki of 12 nM. |
-
J Pharm Biomed Anal, 2020, 180:113019
|
|
S5341 |
Metroprolol succinate
|
Metroprolol Succinate (Metoprolol succinate) is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. |
|
|
S5430 |
Metoprolol
|
Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension. |
-
Cell Rep, 2022, 38(10):110468
|
|
S5432 |
Dibenamine Hydrochloride
|
Dibenamine (N-(2-Chloroethyl)dibenzylamine, Sympatholytin, Dibenzylchlorethamine) is an irreversible blocker of α1 adrenoceptors. |
|
|
S5540 |
Landiolol hydrochloride
|
Landiolol hydrochloride (ONO-1101) is the hydrochloride salt form of Landiolol, which is an ultra-short-acting β1 selective adrenoceptor antagonist. |
|
|
S5666 |
Moxisylyte hydrochloride
|
Moxisylyte hydrochloride (thymoxamine) is an alpha-adrenergic blocking agent used for the treatment of Raynaud's disease. |
|
|
S5766 |
Alfuzosin
|
Alfuzosin, a quinazoline derivative, is a selective and competitive α1-adrenoceptor antagonist. |
|
|
S5778 |
Esmolol
|
Esmolol is a cardioselective beta1 receptor blocker with rapid onset, a very short duration of action, and no significant intrinsic sympathomimetic or membrane stabilising activity at therapeutic dosages. |
|
|
S5780 |
Prazosin
|
Prazosin is an α1-blocker that acts as an inverse agonist at alpha-1 adrenergic receptors. It is used to treat hypertension. |
-
BMC Pharmacol Toxicol, 2020, 21(1):61
|
|
S5782 |
Doxazosin
|
Doxazosin is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors. |
|
|
S5789 |
Propafenone
|
Propafenone (SA-79) is an orally active sodium channel blocking agent and a beta-adrenoceptor (β-adrenergic receptor) antagonist. Propafenone offers a broad spectrum of activity in the treatment of cardiac arrhythmias. |
|
|
S5802 |
Alprenolol hydrochloride
|
Alprenolol hydrochloride is the hydrochloride salt form of alprenolol, which is an beta adrenergic receptorantagonist and is used as an antihypertensive, anti-anginal, and anti-arrhythmic agent. |
|
|
S5923 |
Celiprolol hydrochloride
|
Celiprolol is a β1-adrenoceptor antagonist with partial β2 agonist activity. |
|
|
S5942 |
Bisoprolol
|
Bisoprolol is a cardioselective β1-adrenergic blocking agent used for secondary prevention of myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. |
|
|
S5965 |
Urapidil
|
Urapidil is an antihypertensive drug acting as an α1 adrenoreceptor antagonist and a 5-HT1A agonist. |
|
|
S5981 |
S(-)-Propranolol hydrochloride
|
(S)-(-)-Propranolol hydrochloride, the active enantiomer of propranolol, is a β-Adrenoceptor (β-Adrenergic Receptor) antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively. |
|
|
S6447 |
Carazolol
|
Carazolol is a non-specific β-adrenergic receptor blocking agent and binds to β receptors irreversibly. |
|
|
S7538 |
RS-102895 Hydrochloride
|
RS-102895 hydrochloride (HCl) is a potent antagonist of Chemokine (C-C motif) receptor 2 (CCR2) with IC50 of 360 nM, and shows no effect on CCR1. RS-102895 hydrochloride also inhibits human α1a and α1d receptors, rat brain cortex 5-HT1a receptor in cells with IC50s of 130 nM, 320 nM, 470 nM, respectively. |
|
|
S8114 |
ICI-118551 Hydrochloride
|
ICI-118551 is a highly selective β2-adrenergic receptor antagonist with Ki values of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively. |
-
Biomedicines, 2022, 10(2)487
-
Toxicol In Vitro, 2021, 77:105251
-
iScience, 2021, 24(12):103362
|
|
S9050 |
Boldine
|
Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects. |
|
|
S9285 |
Fargesin
|
Fargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway. |
|
|
E0450New |
Clenbuterol Hydrochloride
|
Clenbuterol (CST-103) Hydrochloride is a potent and selective adrenergic beta 2-receptor agonist.
|
|
|
E1049New |
CL316243
|
CL316243 is a highly potent selective β3-adrenoceptor agonist with a EC50 of 3 nM, but is an extremely poor to β1/2- receptors. |
|
|
S0032 |
Batefenterol
|
Batefenterol (GSK961081, TD-5959) is both a muscarinic receptor antagonist and a β2-adrenoceptor agonist with Ki of 1.4 nM, 1.3 nM and 3.7 nM for hM2, hM3 muscarinic receptors and hβ2-adrenoceptor, respectively. |
|
|
S1437 |
Tizanidine HCl
|
Tizanidine HCl (DS 103-282) is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons. |
-
Drug Metab Dispos, 2021, 49(8):638-647
|
|
S2020 |
Formoterol Hemifumarate
|
Formoterol Hemifumarate (Eformoterol, CGP 25827A, NSC 299587, YM 08316) is a potent, selective and long-acting β2-adrenoceptor agonist used in the management of asthma and chronic obstructive pulmonary disease(COPD). |
|
|
S2083 |
Procaterol HCl
|
Procaterol HCl (OPC-2009) is a short-acting β2-adrenergic receptor agonist with Kp of 8 nM, used for the treatment of asthma
|
|
|
S2090 |
Dexmedetomidine HCl
|
Dexmedetomidine HCl is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation. |
-
Sci Rep, 2021, 11(1):13345
-
Exp Ther Med, 2020, 20(2):917-925
|
|
S2092 |
Detomidine HCl
|
Detomidine HCl produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors. |
-
Nature, 2018, 560(7718):372-376
|
|
S2304 |
Gramine
|
Gramine (Donaxine) is a natural indole alkaloid isolated from giant reed, acts as an active adiponectin receptor (AdipoR) agonist, with IC50 of 3.2 µM and 4.2 µM for AdipoR2 and AdipoR1, respectively. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist. |
|
|
S2362 |
Synephrine
|
Synephrine (Oxedrine), a natural protoalkaloid in the extract of bitter orange and other citrus species, is commonly used for weight loss. |
|
|
S2438 |
Synephrine HCl
|
SynephrineHCl (Oxedrine, p-Synephrine) is a sympathomimetic α-adrenergic receptor (AR) agonist. |
|
|
S2458 |
Clonidine HCl
|
Clonidine HCl is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg. |
|
|
S2507 |
Salbutamol Sulfate
|
Salbutamol Sulfate (Albuterol) is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM. |
-
Front Physiol, 2022, 13:800055
-
cell, 2020, 180(1):64-78.e16
-
Sci Signal, 2020, 13(659)eaax0273
|
|
S2516 |
Xylazine HCl
|
Xylazine is an α2-Adrenergic receptor agonist, used as a sedative and muscle relaxant. |
-
Eur J Pharmacol, 2021, 911:174522
-
Fitoterapia, 2021, 152:104922
-
STAR Protoc, 2021, 2(4):100915
|
|
S2519 |
Naphazoline HCl
|
Naphazoline HCl is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine. |
|
|
S2521 |
Epinephrine bitartrate
|
Epinephrine bitartrate (Adrenalinium) is an alpha- and beta-adrenergic receptor stimulator. |
-
Hum Cell, 2022, 10.1007/s13577-022-00671-y
-
J Immunother Cancer, 2021, 9(1)e001466
-
Hum Cell, 2021, 10.1007/s13577-021-00639-4
|
|
S2522 |
L-Adrenaline
|
L-Adrenaline (Epinephrine) belongs to a group of the compounds known as catecholamines. |
|
|
S2523 |
DL-Adrenaline
|
DL-Adrenaline is a hormone and a neurotransmitter secreted by the medulla of the adrenal glands. |
|
|
S2533 |
Ritodrine HCl
|
Ritodrine HCl (NSC 291565) is a hydrochloride salt of ritodrine which is a β-2 adrenergic receptor agonist. |
|
|
S2545 |
Scopine
|
Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock. |
|
|
S2566 |
Isoprenaline (NCI-C55630) HCl
|
Isoprenaline HCl (NCI-C55630) is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block. |
-
BMC Cancer, 2022, 22(1):213
-
PLoS Pathog, 2020, 16;16(3):e1008341
|
|
S2569 |
Phenylephrine (NCI-C55641) HCl
|
Phenylephrine HCl (NCI-C55641) is a selective α1-adrenergic receptor agonist, used primarily as a decongestant. |
-
Oxid Med Cell Longev, 2021, 2021:7848027
-
Front Pharmacol, 2019, 10:465
-
Sci Adv, 2019, 5(5):eaau0495
|
|
S2576 |
Xylometazoline HCl
|
Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. |
|
|
S2615 |
Noradrenaline bitartrate monohydrate
|
Noradrenaline bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator. |
|
|
S3041 |
Droxidopa
|
Droxidopa (L-DOPS) is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). |
|
|
S3060 |
Medetomidine HCl
|
Medetomidine is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor. |
-
Micromachines, 2018, 9(6)
|
|
S3061 |
Epinephrine HCl
|
Epinephrine HCl (Adrenaline) is a hormone and a neurotransmitter. |
-
J Immunother Cancer, 2021, 9(1)e001466
|
|
S3075 |
Dexmedetomidine
|
Dexmedetomidine is a sedative medication used by intensive care units and anesthetists. |
-
Neural Plast, 2022, 2022:1353778
-
Sci Rep, 2021, 11(1):13345
-
Brain Res Bull, 2021, 174:11-21
|
|
S3083 |
Indacaterol Maleate
|
Indacaterol (QAB149) is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor. |
-
J Allergy Clin Immunol, 2021, S0091-6749(21)00979-9
|
|
S3185 |
Adrenalone HCl
|
Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors. |
|
|
S3294 |
Demethyl-Coclaurine
|
Demethyl-Coclaurine (Higenamine, Norcoclaurine), the key component of the Chinese herb aconite root, is a beta-2 adrenergic receptor (β2-AR) agonist. Demethyl-Coclaurine stimulates AKT phosphorylation and requires PI3K activation for the anti-apoptotic effect in cardiomyocytes. |
|
|
S3640 |
Methoxyphenamine Hydrochloride
|
Methoxyphenamine Hydrochloride (2-methoxy-N-methylamphetamine, OMMA) is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator. |
|
|
S3643 |
Amitraz
|
Amitraz (NSC 324552) is a triazapentadiene, an α2 adrenergic agonist and a member of the amidine chemical family. It is a non-systemic acaricide and insecticide. |
|
|
S3727 |
Vilanterol Trifenate
|
Vilanterol trifenatate (GW642444M) is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma. |
-
Toxicol In Vitro, 2021, 77:105251
-
J Neuroimmunol, 2019, 332:37-48
|
|
S3960 |
Higenamine hydrochloride
|
Higenamine (Norcoclaurine, (+-)-Demethylcoclaurine), also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants. |
-
Oncol Rep, 2021, 46(3)202
-
Mol Cell Biochem, 2021, 10.1007/s11010-021-04197-z
|
|
S4009 |
Mirabegron
|
Mirabegron (YM 178) is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM. |
-
Hum Cell, 2022, 10.1007/s13577-022-00671-y
-
Hum Cell, 2021, 10.1007/s13577-021-00639-4
-
Hum Cell, 2021, 34(6):1911-1918
|
|
S4043 |
Tetrahydrozoline HCl
|
Tetrahydrozoline (Tetryzoline) HCl is an imidazoline derivative with alpha receptor agonist activity. |
|
|
S4065 |
Guanabenz Acetate
|
Guanabenz Acetate (WY-8678) is an selective agonist of α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor with pEC50 of 8.25, 7.01 and ~5, respectively. |
-
Cell Stem Cell, 2020, 27(6):876-889.e12
-
Thyroid, 2019, 29(6):809-823
|
|
S4127 |
Terbutaline Sulfate
|
Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 nM. |
-
BMC Pharmacol Toxicol, 2020, 21(1):61
-
Hum Reprod, 2016, 31(11):2506-2519
|
|
S4135 |
Clorprenaline HCl
|
Clorprenaline HCl (NSC 334693) is a β2-receptor agonist, it has a significant expansion of the bronchial effect. |
|
|
S4266 |
Brimonidine Tartrate
|
Brimonidine Tartrate is a highly selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma or ocular hypertension. |
|
|
S4277 |
Bambuterol HCl
|
Bambuterol HCl is a potent β-adrenoceptor agonist, used in the treatment of asthma.
|
|
|
S4296 |
Salmeterol Xinafoate
|
Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms.
|
-
ACS Pharmacol Transl Sci, 2019, 2(3):148-154
-
Commun Biol, 2018, 1:106
|
|
S4481 |
Guanabenz
|
Guanabenz (GBZ, GA, Wytensin, Wy-8678) is an orally active central alpha 2-adrenoceptor (α2 adrenergic receptor) agonist with antihypertensive action. |
|
|
S4485 |
Olodaterol (BI 1744)
|
Olodaterol (BI 1744) is a long-acting β2-adrenergic receptor agonist that is used as a component of an inhalation (Tiotropium/Olodaterol) for treating patients with chronic obstructive pulmonary disease (COPD). |
|
|
S4693 |
Guanfacine Hydrochloride
|
Guanfacine Hydrochloride (Tenex, Intuniv) is a selective α2A-adrenoceptor agonist with anti-hypertensive effect. |
|
|
S5217 |
Arformoterol Tartrate
|
Arformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity. |
|
|
S5267 |
Nylidrin Hydrochloride
|
Nylidrin Hydrochloride (Buphenine), a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well. |
|
|
S5494 |
Salbutamol
|
Salbutamol (Albuterol) is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases. |
-
Front Physiol, 2022, 13:800055
-
BMC Pharmacol Toxicol, 2020, 21(1):61
|
|
S5527 |
Salmeterol
|
Salmeterol (Astmerole, GR-33343X, SN408D) is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500). |
-
Mol Syst Biol, 2021, 17(8):e10239
-
Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S5537 |
Tizanidine
|
Tizanidine is an imidazoline derivative and a centrally acting α2 adrenergic agonist used as a muscle relaxant for therapy of acute muscle spasms and chronic spasticity. |
-
Drug Metab Dispos, 2021, 49(8):638-647
|
|
S5564 |
Xylazine
|
Xylazine is a partial alpha-2 adrenergic agonist that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. |
-
Cell Death Differ, 2020, 10.1038
-
Mol Med Rep, 2017, 16(2):1911-1919
|
|
S5654 |
Indacaterol
|
Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor. |
-
Drug Test Anal, 2020, 10.1002/dta.2917
-
J Neuroimmunol, 2019, 332:37-48
|
|
S5669 |
Isoxsuprine hydrochloride
|
Isoxsuprine hydrochloride is a beta-adrenergic agonist with vasodilator activity. |
|
|
S5683 |
Isoproterenol sulfate dihydrate
|
Isoproterenol Sulfate is the sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity. |
-
Cell Biol Toxicol, 2021, 10.1007/s10565-021-09615-y
-
Biochim Biophys Acta Mol Cell Res, 2021, 1868(10):119080
|
|
S5727 |
Tetryzoline
|
Tetryzoline (Tetrahydrozoline) is an alpha-adrenergic agonist used in some over-the-counter eye drops and nasal sprays. |
|
|
S5734 |
Midodrine hydrochloride
|
Midodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor. |
|
|
S5735 |
Midodrine
|
Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist. |
|
|
S5750 |
DL-Norepinephrine hydrochloride
|
Norepinephrine (noradrenaline) is the neurotransmitter at most sympathetic neuroeffector junctions and has pharmacologic effects on both α1 and β1 adrenoceptors. |
|
|
S5751 |
Dihydroergotamine Mesylate
|
Dihydroergotamine Mesylate is an ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors. |
|
|
S5768 |
Fenoterol hydrobromide
|
Fenoterol hydrobromide (Phenoterol) is the the hydrobromide salt of fenoterol, a β2 adrenoreceptor agonist with bronchodilator activity. |
-
Toxicol In Vitro, 2021, 77:105251
|
|
S5769 |
Fenoterol
|
Fenoterol (Phenoterol) is a β2 adrenoreceptor agonist with bronchodilator activity. |
|
|
S5925 |
Olodaterol hydrochloride
|
Olodaterol hydrochloride (BI-1744) is the hydrochloride salt form of Olodaterol, which is a long-acting beta2-adrenergic agonist. |
|
|
S5954 |
L-(-)-α-Methyldopa hydrate
|
L-(-)-α-Methyldopa (Methyldopa, MK-351) hydrate, a potent antihypertensive drug, is a selective agonist for α2-adrenergic receptors. |
|
|
S6487 |
fluticasone furoate
|
Fluticasone furoate (GW685698) is an inhaled corticosteroid/long-acting beta-agonist combination with a prolonged bronchodilator duration of action. It is used for the treatment of non-allergic and allergic rhinitis administered by a nasal spray. |
|
|
S6583 |
Apraclonidine HCl
|
Apraclonidine (Iopidine) is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist. |
|
|
S7974 |
L755507
|
L-755,507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types. |
-
Genesis, 2022, 60(1-2):e23465
-
Chembiochem, 2021, 22(20):2957-2965
-
Hum Mutat, 2019, 10.1002/humu.23848
|
|
S9507 |
(−)-Norepinephrine
|
(−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively. |
-
Commun Biol, 2022, 5(1):339
-
Eur J Pharmacol, 2022, 926:175040
-
Cardiovasc Drugs Ther, 2020, 11
|
|
S9508 |
Brimonidine
|
Brimonidine (Bromoxidine, UK 1430) is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure. |
|
|
S3153 |
Levalbuterol tartrate
|
Levalbuterol HCl is a relatively selective beta2-adrenergic receptor agonist used for the treatment of asthma. |
|
|
S4243 |
Deoxycorticosterone acetate
|
Deoxycorticosterone acetate (11-Deoxycorticosterone, DOC, Cortexone) is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid. |
-
Nat Cancer, 2020, 1(2):235-248
|
|
S0116 |
Piperoxan hydrochloride
|
Piperoxan hydrochloride (Benodaine, Fourneau 933, F933, DL-Piperoxan) is an antagonist of α2 (alpha 2) adrenoceptor. |
|
|
S0812 |
SR59230A
|
SR59230A is a blood-brain barrier penetrating, potent and selective antagonist of β3-adrenergic receptor with IC50 of 40 nM, 408 nM, and 648 nM for β3, β1, and β2 receptors, respectively. |
|
|
S0862 |
L-765314
|
L-765314 is a selective and potent α1b-adrenoceptor (α1b adrenergic receptor) antagonist with an IC50 of 1.90 nM and Kis of 5.4 and 2.0 for rat and human α1b adrenergic receptor, respectively. |
|
|
S1283 |
Asenapine maleate
|
Asenapine maleate (Org 5222) is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder. |
- Biochem Biophys Res Commun, 2021, 553:172-179
- Anticancer Res, 2021, 41(2):687-697
- Sci Rep, 2018, 8(1):15753
|
|
S1387 |
Naftopidil DiHCl
|
Naftopidil DiHCl (KT-611) is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively. |
|
|
S1409 |
Alfuzosin HCl
|
Alfuzosin HCl is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH). |
- Prostate, 2016, 76(8):757-66
|
|
S1424 |
Prazosin HCl
|
Prazosin HCl (cp-12299-1) is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia. |
- BMC Pharmacol Toxicol, 2020, 21(1):61
|
|
S1435 |
Tamsulosin hydrochloride
|
Tamsulosin (Flomax) hydrochloride is an antagonist of alpha1A adrenoceptors in the prostate. |
|
|
S1549 |
Nebivolol hydrochloride (R-65824)
|
Nebivolol HCl (R-65824) selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM. |
- Oncogenesis, 2022, 11(1):24
- Nat Commun, 2021, 12(1):5919
- Front Pharmacol, 2021, 12:691998
|
|
S1613 |
Silodosin
|
Silodosin (KAD 3213, KMD 3213) is a highly selective α1A-adrenoceptor antagonist, used in treatment of benign prostatic hyperplasia. |
|
|
S1827 |
Betaxolol HCl
|
Betaxolol (SL 75212) is a β1 adrenergic receptor blocker with IC50 of 6 μM. |
- Chirality, 2018, 30(11):1195-1205
|
|
S1831 |
Carvedilol
|
Carvedilol (BM-14190, SKF 105517) is a non-selective beta blocker/alpha-1 blocker, used to treat congestive heart failure (CHF) and high blood pressure. |
- PLoS Pathog, 2020, 16;16(3):e1008341
- Res Pharm Sci, 2016, 11(5):419-427
- Res Pharm Sci, 2015, 10(5):388-96
|
|
S1856 |
Metoprolol Tartrate
|
Metoprolol Tartrate (CGP 2175E) is a selective β1 receptor blocker medication, used to treat hypertension and heart failure. |
|
|
S2038 |
Phentolamine Mesylate
|
Phentolamine Mesylate is a reversible and nonselective alpha-adrenergic receptor antagonist, used for the prevention or control of hypertensive episodes. |
- Oncol Rep, 2021, 46(3)202
|
|
S2059 |
Terazosin HCl Dihydrate
|
Terazosin HCl is a selective α1-adrenoceptor antagonist, used for treatment of symptoms of an enlarged prostate (BPH). |
- J Biomed Sci, 2021, 28(1):8
|
|
S2091 |
Betaxolol
|
Betaxolol (SL 75212) is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma. |
- Nat Commun, 2020, 24;11(1):1990
- Chirality, 2018, 30(11):1195-1205
|
|
S2126 |
Naftopidil
|
Naftopidil (KT-611) is a selective α1-adrenergic receptor antagonist with Ki of 3.7 nM, 20 nM, and 1.2 nM for α1a, α1b, and α1d, respectively, used for the treatment of benign prostatic hyperplasia. |
- Cell Syst, 2019, 8(2):97-108
|
|
S2174New |
Hydroxyflutamide (Hydroxyniphtholide)
|
Hydroxyflutamide (SCH-16423, Hydroxyniphtholide) is an androgen receptor (AR) antagonist and possesses an IC50 of 0.7 μM for the androgen receptor.
|
|
|
S2373 |
Yohimbine HCl
|
Yohimbine (Antagonil) has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac. |
- J Med Chem, 2021, 64(18):13510-13523
- J Inflamm Res, 2021, 14:1217-1233
- J Med Virol, 2019, 91(8):1440-1447
|
|
S2499 |
Phenoxybenzamine HCl
|
Phenoxybenzamine HCl (NSC 37448, NCI-c01661) is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM. |
|
|
S2509 |
Sotalol HCl
|
Sotalol is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM. |
- Toxicol Appl Pharmacol, 2021, 431:115731
- Gynecol Oncol, 2018, 151(3):525-532
- Toxicol Appl Pharmacol, 2015, 285(1):51-60
|
|
S2517 |
Maprotiline HCl
|
Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression. |
- Front Pharmacol, 2021, 12:689767
|
|
S2607 |
Buflomedil HCl
|
Buflomedil HCl is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease; A nonselective alpha adrenergic receptor inhibitor. |
|
|
S2691 |
BMY 7378 Dihydrochloride
|
BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3. |
|
|
S3656 |
Piribedil
|
Piribedil (Trivastal, Trivastan) is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties. |
|
|
S3664 |
Flupentixol dihydrochloride
|
Flupentixol (Flupenthixol) dihydrochloride, an antipsychotic neuroleptic drug, is a powerful antagonist of both D1 and D2 dopamine receptors and also an alpha-adrenergic receptor antagonist. |
|
|
S4010 |
Acebutolol HCl
|
Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias. |
- Front Pharmacol, 2021, 12:740529
|
|
S4085 |
Levobetaxolol HCl
|
Levobetaxolol (AL 1577A) exhibits a higher affinity at cloned human β1 and β2 receptors with Ki value of 0.76 nM and 32.6 nM, respectively. |
|
|
S4100 |
Esmolol HCl
|
Esmolol (ASL8052) is a cardioselective b-blocker, used to control rapid heartbeats or abnormal heart rhythms. |
|
|
S4123 |
Timolol Maleate
|
Timolol Maleate (MK-950) is a non-selective, beta-adrenergic receptor antagonist for β1/β2 with Ki of 1.97 nM/2.0 nM. |
- J Dermatolog Treat, 2020, 24:1-7
|
|
S4124 |
Tolazoline HCl
|
Tolazoline is a non-selective competitive α-adrenergic receptor antagonist. |
- Insect Biochem Mol Biol, 2017, 90:61-70
|
|
S4278 |
Carteolol HCl
|
Carteolol HCl is a β-adrenoceptor antagonist, used for the treatment of glaucoma.
|
|
|
S4291 |
Labetalol HCl
|
Labetalol HCl is a dual antagonist for both selective alpha1-adrenergic and nonselective beta-adrenergic receptors, used in the treatment of high blood pressure.
|
|
|
S4358 |
Pimozide
|
Pimozide (Orap, R6238) is an antagonist of Dopamine Receptors with Ki of 0.83 nM, 3.0 nM and 6600 nM for dopamine D3, D2 and D1 receptors, respectively. Pimozide also exhibits binding affinity at α2-adrenoceptor and 5-HT1A with Ki of 360 nM and 310 nM, respectively. Pimozide is an antipsychotic drug with anti-tumor activity and suppresses STAT3 and STAT5 activity. |
- Biol Pharm Bull, 2021, 10.1248/bpb.b21-00531
|
|
S4649 |
Atipamezole hydrochloride
|
Atipamezole (Antisedan, MPV1248) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. Atipamezole hydrochloride is hydrochloride form of atipamezole. |
|
|
S4650 |
Atipamezole
|
Atipamezole (MPV-1248, MPV1248, Antisedan) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. |
- Exp Mol Med, 2020, 10.1038/s12276-020-0461-6
- Nitric Oxide, 2019, 85:1-9
- Front Neurol, 2019, 10:1041
|
|
S4679 |
Terazosin HCl
|
Terazosin (Hytrin, Zayasel, Terazosine, Flumarc, Fosfomic, Blavin) is a selective alpha-1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls. |
- J Biomed Sci, 2021, 28(1):8
|
|
S4797 |
Nicergoline
|
Nicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins. It has a selective alpha-1A adrenergic receptor blocking property and also other additional mechanisms of actions. |
|
|
S4817 |
Atenolol
|
Atenolol (Tenormin, Normiten, Blokium) is a selective β1 receptor antagonist with log Kd values of −6.66±0.05, −5.99±0.14, −4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors. |
- Oncol Rep, 2021, 46(3)202
|
|
S5023 |
Nadolol
|
Nadolol (Corgard, Solgol, Anabet, SQ11725) is a non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities. |
|
|
S5042 |
Bevantolol hydrochloride
|
Bevantolol hydrochloride (NC-1400) is a cardioselective, beta adrenoceptor antagonist, devoid of intrinsic β sympathomimetic activity and with weak membrane-stabilizing and local anesthetic properties. |
|
|
S5281 |
Dapiprazole Hydrochloride
|
Dapiprazole Hydrochloride (Glamidolo Hydrochloride, Reversil Hydrochloride) is the hydrochloride salt form of dapiprazole, an alpha-adrenergic blocker used to reverse mydriasis after eye examination. |
|
|
S5337 |
Rauwolscine hydrochloride
|
Rauwolscine hydrochloride (Isoyohimbine, α-Yohimbine, corynanthidine) is the hydrochloride salt form of Rauwolscine, a specific and potent α2 antagonist with Ki of 12 nM. |
- J Pharm Biomed Anal, 2020, 180:113019
|
|
S5341 |
Metroprolol succinate
|
Metroprolol Succinate (Metoprolol succinate) is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. |
|
|
S5430 |
Metoprolol
|
Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension. |
- Cell Rep, 2022, 38(10):110468
|
|
S5432 |
Dibenamine Hydrochloride
|
Dibenamine (N-(2-Chloroethyl)dibenzylamine, Sympatholytin, Dibenzylchlorethamine) is an irreversible blocker of α1 adrenoceptors. |
|
|
S5540 |
Landiolol hydrochloride
|
Landiolol hydrochloride (ONO-1101) is the hydrochloride salt form of Landiolol, which is an ultra-short-acting β1 selective adrenoceptor antagonist. |
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S5666 |
Moxisylyte hydrochloride
|
Moxisylyte hydrochloride (thymoxamine) is an alpha-adrenergic blocking agent used for the treatment of Raynaud's disease. |
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S5766 |
Alfuzosin
|
Alfuzosin, a quinazoline derivative, is a selective and competitive α1-adrenoceptor antagonist. |
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S5778 |
Esmolol
|
Esmolol is a cardioselective beta1 receptor blocker with rapid onset, a very short duration of action, and no significant intrinsic sympathomimetic or membrane stabilising activity at therapeutic dosages. |
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S5780 |
Prazosin
|
Prazosin is an α1-blocker that acts as an inverse agonist at alpha-1 adrenergic receptors. It is used to treat hypertension. |
- BMC Pharmacol Toxicol, 2020, 21(1):61
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S5782 |
Doxazosin
|
Doxazosin is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors. |
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S5789 |
Propafenone
|
Propafenone (SA-79) is an orally active sodium channel blocking agent and a beta-adrenoceptor (β-adrenergic receptor) antagonist. Propafenone offers a broad spectrum of activity in the treatment of cardiac arrhythmias. |
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S5802 |
Alprenolol hydrochloride
|
Alprenolol hydrochloride is the hydrochloride salt form of alprenolol, which is an beta adrenergic receptorantagonist and is used as an antihypertensive, anti-anginal, and anti-arrhythmic agent. |
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S5923 |
Celiprolol hydrochloride
|
Celiprolol is a β1-adrenoceptor antagonist with partial β2 agonist activity. |
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S5942 |
Bisoprolol
|
Bisoprolol is a cardioselective β1-adrenergic blocking agent used for secondary prevention of myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. |
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S5965 |
Urapidil
|
Urapidil is an antihypertensive drug acting as an α1 adrenoreceptor antagonist and a 5-HT1A agonist. |
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S5981 |
S(-)-Propranolol hydrochloride
|
(S)-(-)-Propranolol hydrochloride, the active enantiomer of propranolol, is a β-Adrenoceptor (β-Adrenergic Receptor) antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively. |
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S6447 |
Carazolol
|
Carazolol is a non-specific β-adrenergic receptor blocking agent and binds to β receptors irreversibly. |
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S7538 |
RS-102895 Hydrochloride
|
RS-102895 hydrochloride (HCl) is a potent antagonist of Chemokine (C-C motif) receptor 2 (CCR2) with IC50 of 360 nM, and shows no effect on CCR1. RS-102895 hydrochloride also inhibits human α1a and α1d receptors, rat brain cortex 5-HT1a receptor in cells with IC50s of 130 nM, 320 nM, 470 nM, respectively. |
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S8114 |
ICI-118551 Hydrochloride
|
ICI-118551 is a highly selective β2-adrenergic receptor antagonist with Ki values of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively. |
- Biomedicines, 2022, 10(2)487
- Toxicol In Vitro, 2021, 77:105251
- iScience, 2021, 24(12):103362
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S9050 |
Boldine
|
Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects. |
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S9285 |
Fargesin
|
Fargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway. |
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E0450New |
Clenbuterol Hydrochloride
|
Clenbuterol (CST-103) Hydrochloride is a potent and selective adrenergic beta 2-receptor agonist.
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E1049New |
CL316243
|
CL316243 is a highly potent selective β3-adrenoceptor agonist with a EC50 of 3 nM, but is an extremely poor to β1/2- receptors. |
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S0032 |
Batefenterol
|
Batefenterol (GSK961081, TD-5959) is both a muscarinic receptor antagonist and a β2-adrenoceptor agonist with Ki of 1.4 nM, 1.3 nM and 3.7 nM for hM2, hM3 muscarinic receptors and hβ2-adrenoceptor, respectively. |
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S1437 |
Tizanidine HCl
|
Tizanidine HCl (DS 103-282) is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons. |
- Drug Metab Dispos, 2021, 49(8):638-647
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S2020 |
Formoterol Hemifumarate
|
Formoterol Hemifumarate (Eformoterol, CGP 25827A, NSC 299587, YM 08316) is a potent, selective and long-acting β2-adrenoceptor agonist used in the management of asthma and chronic obstructive pulmonary disease(COPD). |
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S2083 |
Procaterol HCl
|
Procaterol HCl (OPC-2009) is a short-acting β2-adrenergic receptor agonist with Kp of 8 nM, used for the treatment of asthma
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S2090 |
Dexmedetomidine HCl
|
Dexmedetomidine HCl is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation. |
- Sci Rep, 2021, 11(1):13345
- Exp Ther Med, 2020, 20(2):917-925
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S2092 |
Detomidine HCl
|
Detomidine HCl produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors. |
- Nature, 2018, 560(7718):372-376
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S2304 |
Gramine
|
Gramine (Donaxine) is a natural indole alkaloid isolated from giant reed, acts as an active adiponectin receptor (AdipoR) agonist, with IC50 of 3.2 µM and 4.2 µM for AdipoR2 and AdipoR1, respectively. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist. |
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S2362 |
Synephrine
|
Synephrine (Oxedrine), a natural protoalkaloid in the extract of bitter orange and other citrus species, is commonly used for weight loss. |
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S2438 |
Synephrine HCl
|
SynephrineHCl (Oxedrine, p-Synephrine) is a sympathomimetic α-adrenergic receptor (AR) agonist. |
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S2458 |
Clonidine HCl
|
Clonidine HCl is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg. |
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S2507 |
Salbutamol Sulfate
|
Salbutamol Sulfate (Albuterol) is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM. |
- Front Physiol, 2022, 13:800055
- cell, 2020, 180(1):64-78.e16
- Sci Signal, 2020, 13(659)eaax0273
|
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S2516 |
Xylazine HCl
|
Xylazine is an α2-Adrenergic receptor agonist, used as a sedative and muscle relaxant. |
- Eur J Pharmacol, 2021, 911:174522
- Fitoterapia, 2021, 152:104922
- STAR Protoc, 2021, 2(4):100915
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S2519 |
Naphazoline HCl
|
Naphazoline HCl is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine. |
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S2521 |
Epinephrine bitartrate
|
Epinephrine bitartrate (Adrenalinium) is an alpha- and beta-adrenergic receptor stimulator. |
- Hum Cell, 2022, 10.1007/s13577-022-00671-y
- J Immunother Cancer, 2021, 9(1)e001466
- Hum Cell, 2021, 10.1007/s13577-021-00639-4
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S2522 |
L-Adrenaline
|
L-Adrenaline (Epinephrine) belongs to a group of the compounds known as catecholamines. |
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S2523 |
DL-Adrenaline
|
DL-Adrenaline is a hormone and a neurotransmitter secreted by the medulla of the adrenal glands. |
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S2533 |
Ritodrine HCl
|
Ritodrine HCl (NSC 291565) is a hydrochloride salt of ritodrine which is a β-2 adrenergic receptor agonist. |
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S2545 |
Scopine
|
Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock. |
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S2566 |
Isoprenaline (NCI-C55630) HCl
|
Isoprenaline HCl (NCI-C55630) is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block. |
- BMC Cancer, 2022, 22(1):213
- PLoS Pathog, 2020, 16;16(3):e1008341
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S2569 |
Phenylephrine (NCI-C55641) HCl
|
Phenylephrine HCl (NCI-C55641) is a selective α1-adrenergic receptor agonist, used primarily as a decongestant. |
- Oxid Med Cell Longev, 2021, 2021:7848027
- Front Pharmacol, 2019, 10:465
- Sci Adv, 2019, 5(5):eaau0495
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S2576 |
Xylometazoline HCl
|
Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. |
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S2615 |
Noradrenaline bitartrate monohydrate
|
Noradrenaline bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator. |
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S3041 |
Droxidopa
|
Droxidopa (L-DOPS) is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). |
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S3060 |
Medetomidine HCl
|
Medetomidine is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor. |
- Micromachines, 2018, 9(6)
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|
S3061 |
Epinephrine HCl
|
Epinephrine HCl (Adrenaline) is a hormone and a neurotransmitter. |
- J Immunother Cancer, 2021, 9(1)e001466
|
|
S3075 |
Dexmedetomidine
|
Dexmedetomidine is a sedative medication used by intensive care units and anesthetists. |
- Neural Plast, 2022, 2022:1353778
- Sci Rep, 2021, 11(1):13345
- Brain Res Bull, 2021, 174:11-21
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S3083 |
Indacaterol Maleate
|
Indacaterol (QAB149) is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor. |
- J Allergy Clin Immunol, 2021, S0091-6749(21)00979-9
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S3185 |
Adrenalone HCl
|
Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors. |
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S3294 |
Demethyl-Coclaurine
|
Demethyl-Coclaurine (Higenamine, Norcoclaurine), the key component of the Chinese herb aconite root, is a beta-2 adrenergic receptor (β2-AR) agonist. Demethyl-Coclaurine stimulates AKT phosphorylation and requires PI3K activation for the anti-apoptotic effect in cardiomyocytes. |
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S3640 |
Methoxyphenamine Hydrochloride
|
Methoxyphenamine Hydrochloride (2-methoxy-N-methylamphetamine, OMMA) is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator. |
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S3643 |
Amitraz
|
Amitraz (NSC 324552) is a triazapentadiene, an α2 adrenergic agonist and a member of the amidine chemical family. It is a non-systemic acaricide and insecticide. |
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S3727 |
Vilanterol Trifenate
|
Vilanterol trifenatate (GW642444M) is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma. |
- Toxicol In Vitro, 2021, 77:105251
- J Neuroimmunol, 2019, 332:37-48
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S3960 |
Higenamine hydrochloride
|
Higenamine (Norcoclaurine, (+-)-Demethylcoclaurine), also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants. |
- Oncol Rep, 2021, 46(3)202
- Mol Cell Biochem, 2021, 10.1007/s11010-021-04197-z
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|
S4009 |
Mirabegron
|
Mirabegron (YM 178) is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM. |
- Hum Cell, 2022, 10.1007/s13577-022-00671-y
- Hum Cell, 2021, 10.1007/s13577-021-00639-4
- Hum Cell, 2021, 34(6):1911-1918
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S4043 |
Tetrahydrozoline HCl
|
Tetrahydrozoline (Tetryzoline) HCl is an imidazoline derivative with alpha receptor agonist activity. |
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S4065 |
Guanabenz Acetate
|
Guanabenz Acetate (WY-8678) is an selective agonist of α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor with pEC50 of 8.25, 7.01 and ~5, respectively. |
- Cell Stem Cell, 2020, 27(6):876-889.e12
- Thyroid, 2019, 29(6):809-823
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S4127 |
Terbutaline Sulfate
|
Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 nM. |
- BMC Pharmacol Toxicol, 2020, 21(1):61
- Hum Reprod, 2016, 31(11):2506-2519
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S4135 |
Clorprenaline HCl
|
Clorprenaline HCl (NSC 334693) is a β2-receptor agonist, it has a significant expansion of the bronchial effect. |
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S4266 |
Brimonidine Tartrate
|
Brimonidine Tartrate is a highly selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma or ocular hypertension. |
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S4277 |
Bambuterol HCl
|
Bambuterol HCl is a potent β-adrenoceptor agonist, used in the treatment of asthma.
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S4296 |
Salmeterol Xinafoate
|
Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms.
|
- ACS Pharmacol Transl Sci, 2019, 2(3):148-154
- Commun Biol, 2018, 1:106
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|
S4481 |
Guanabenz
|
Guanabenz (GBZ, GA, Wytensin, Wy-8678) is an orally active central alpha 2-adrenoceptor (α2 adrenergic receptor) agonist with antihypertensive action. |
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S4485 |
Olodaterol (BI 1744)
|
Olodaterol (BI 1744) is a long-acting β2-adrenergic receptor agonist that is used as a component of an inhalation (Tiotropium/Olodaterol) for treating patients with chronic obstructive pulmonary disease (COPD). |
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S4693 |
Guanfacine Hydrochloride
|
Guanfacine Hydrochloride (Tenex, Intuniv) is a selective α2A-adrenoceptor agonist with anti-hypertensive effect. |
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S5217 |
Arformoterol Tartrate
|
Arformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity. |
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|
S5267 |
Nylidrin Hydrochloride
|
Nylidrin Hydrochloride (Buphenine), a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well. |
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S5494 |
Salbutamol
|
Salbutamol (Albuterol) is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases. |
- Front Physiol, 2022, 13:800055
- BMC Pharmacol Toxicol, 2020, 21(1):61
|
|
S5527 |
Salmeterol
|
Salmeterol (Astmerole, GR-33343X, SN408D) is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500). |
- Mol Syst Biol, 2021, 17(8):e10239
- Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S5537 |
Tizanidine
|
Tizanidine is an imidazoline derivative and a centrally acting α2 adrenergic agonist used as a muscle relaxant for therapy of acute muscle spasms and chronic spasticity. |
- Drug Metab Dispos, 2021, 49(8):638-647
|
|
S5564 |
Xylazine
|
Xylazine is a partial alpha-2 adrenergic agonist that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. |
- Cell Death Differ, 2020, 10.1038
- Mol Med Rep, 2017, 16(2):1911-1919
|
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S5654 |
Indacaterol
|
Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor. |
- Drug Test Anal, 2020, 10.1002/dta.2917
- J Neuroimmunol, 2019, 332:37-48
|
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S5669 |
Isoxsuprine hydrochloride
|
Isoxsuprine hydrochloride is a beta-adrenergic agonist with vasodilator activity. |
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S5683 |
Isoproterenol sulfate dihydrate
|
Isoproterenol Sulfate is the sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity. |
- Cell Biol Toxicol, 2021, 10.1007/s10565-021-09615-y
- Biochim Biophys Acta Mol Cell Res, 2021, 1868(10):119080
|
|
S5727 |
Tetryzoline
|
Tetryzoline (Tetrahydrozoline) is an alpha-adrenergic agonist used in some over-the-counter eye drops and nasal sprays. |
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S5734 |
Midodrine hydrochloride
|
Midodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor. |
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S5735 |
Midodrine
|
Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist. |
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S5750 |
DL-Norepinephrine hydrochloride
|
Norepinephrine (noradrenaline) is the neurotransmitter at most sympathetic neuroeffector junctions and has pharmacologic effects on both α1 and β1 adrenoceptors. |
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S5751 |
Dihydroergotamine Mesylate
|
Dihydroergotamine Mesylate is an ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors. |
|
|
S5768 |
Fenoterol hydrobromide
|
Fenoterol hydrobromide (Phenoterol) is the the hydrobromide salt of fenoterol, a β2 adrenoreceptor agonist with bronchodilator activity. |
- Toxicol In Vitro, 2021, 77:105251
|
|
S5769 |
Fenoterol
|
Fenoterol (Phenoterol) is a β2 adrenoreceptor agonist with bronchodilator activity. |
|
|
S5925 |
Olodaterol hydrochloride
|
Olodaterol hydrochloride (BI-1744) is the hydrochloride salt form of Olodaterol, which is a long-acting beta2-adrenergic agonist. |
|
|
S5954 |
L-(-)-α-Methyldopa hydrate
|
L-(-)-α-Methyldopa (Methyldopa, MK-351) hydrate, a potent antihypertensive drug, is a selective agonist for α2-adrenergic receptors. |
|
|
S6487 |
fluticasone furoate
|
Fluticasone furoate (GW685698) is an inhaled corticosteroid/long-acting beta-agonist combination with a prolonged bronchodilator duration of action. It is used for the treatment of non-allergic and allergic rhinitis administered by a nasal spray. |
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S6583 |
Apraclonidine HCl
|
Apraclonidine (Iopidine) is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist. |
|
|
S7974 |
L755507
|
L-755,507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types. |
- Genesis, 2022, 60(1-2):e23465
- Chembiochem, 2021, 22(20):2957-2965
- Hum Mutat, 2019, 10.1002/humu.23848
|
|
S9507 |
(−)-Norepinephrine
|
(−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively. |
- Commun Biol, 2022, 5(1):339
- Eur J Pharmacol, 2022, 926:175040
- Cardiovasc Drugs Ther, 2020, 11
|
|
S9508 |
Brimonidine
|
Brimonidine (Bromoxidine, UK 1430) is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure. |
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