Adrenergic Receptor

Signaling Pathway Map

Research Area

Inhibitory Selectivity

Isoform-specific Inhibitors

Adrenergic Receptor Products

All (125) Adrenergic Receptor Inhibitors (12) Adrenergic Receptor Antagonists (52) Adrenergic Receptor Agonists (59) Adrenergic Receptor Chemicals (2) New Adrenergic Receptor Products

Catalog No.	Information	Product Use Citations	Product Validations
S1324	Doxazosin Mesylate Doxazosin, a quinazoline-derivative, selectively antagonizes postsynaptic α1-adrenergic receptors, used in the treatment of high blood pressure and urinary retention associated with benign prostatic hyperplasia.	J Clin Invest, 2013, 123(12):5119-34 Antiviral Res, 2015, 120:140-6 J Ocul Pharmacol Ther, 2017, 33(1):50-56
S5703^New	Carvedilol Phosphate Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.
S5723^New	Carvedilol EP IMpurity E Carvedilol is a nonselective beta blocker/alpha-1 blocker and used in management of congestive heart failure (CHF).
S5739^New	Nebivolol Nebivolol is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.
S4076	Propranolol HCl Propranolol HCl is a competitive non-selective beta-adrenergic receptors inhibitor with IC50 of 12 nM.
S1206	Bisoprolol fumarate Bisoprolol fumarate is a selective type β1 adrenergic receptor blocker.	J Cell Mol Med, 2018, 22(12):5964-5977 J Toxicol Sci, 2017, 42(6):755-761
S4113	Desvenlafaxine Desvenlafaxine is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with K_i of 40.2 nM and 558.4 nM, respectively.
S5088	Labetalone hydrochloride Labetalone hydrochloride is hydrochloride form of labetalone, a blocker of both alpha- and beta-adrenergic receptors that is used as an antihypertensive.
S1642	Methyldopa Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.
S4112	Desvenlafaxine Succinate Desvenlafaxine Succinate is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with K_i of 40.2 nM and 558.4 nM respectively.
S2086	Ivabradine HCl Ivabradine HCl, a new I_f inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.
S2113	Cisatracurium Besylate Cisatracurium Besylate is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.
S1283	Asenapine maleate Asenapine maleate is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder.
S6447^New	Carazolol Carazolol is a non-specific β-adrenergic receptor blocking agent and binds to β receptors irreversibly.
S5942^New	Bisoprolol Bisoprolol is a cardioselective β1-adrenergic blocking agent used for secondary prevention of myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension.
S5782^New	Doxazosin Doxazosin is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors.
S5923^New	Celiprolol hydrochloride Celiprolol is a β1-adrenoceptor antagonist with partial β2 agonist activity.
S5778^New	Esmolol Esmolol is a cardioselective beta1 receptor blocker with rapid onset, a very short duration of action, and no significant intrinsic sympathomimetic or membrane stabilising activity at therapeutic dosages.
S5780^New	Prazosin Prazosin is an α1-blocker that acts as an inverse agonist at alpha-1 adrenergic receptors. It is used to treat hypertension.
S5766^New	Alfuzosin Alfuzosin, a quinazoline derivative, is a selective and competitive α1-adrenoceptor antagonist.
S5802^New	Alprenolol hydrochloride Alprenolol hydrochloride is the hydrochloride salt form of alprenolol, which is an beta adrenergic receptorantagonist and is used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.
S5666^New	Moxisylyte hydrochloride Moxisylyte hydrochloride is an alpha-adrenergic blocking agent used for the treatment of Raynaud's disease.
S9285^New	Fargesin Fargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway.
s9050^New	Boldine Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects.
S1435^New	Tamsulosin hydrochloride Tamsulosin hydrochloride is an antagonist of alpha1A adrenoceptors in the prostate.
S5540^New	Landiolol hydrochloride Landiolol hydrochloride is the hydrochloride salt form of Landiolol, which is an ultra-short-acting β1 selective adrenoceptor antagonist.
S5341^New	Metroprolol succinate Metoprolol Succinate is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity.
S5430^New	Metoprolol Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension.
S5281^New	Dapiprazole Hydrochloride Dapiprazole Hydrochloride is the hydrochloride salt form of dapiprazole, an alpha-adrenergic blocker used to reverse mydriasis after eye examination.
S5432^New	Dibenamine Hydrochloride Dibenamine is an irreversible blocker of α1 adrenoceptors.
S5337^New	Rauwolscine hydrochloride Rauwolscine hydrochloride is the hydrochloride salt form of Rauwolscine, a specific and potent α2 antagonist with Ki of 12 nM.
S1409	Alfuzosin HCl Alfuzosin HCl is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).	Prostate, 2016, 76(8):757-66	PC-3 and LNCaP cell viability following treatment with a1-adrenoceptor antagonists. (A) Cells were treated with drug (0.01-100 μM) for 72 hr and cell viability determined using the resazurin reduction assay. (B) Effect of treatment duration on PC-3 and LNCap cell survival following treatment with doxazosin (30 μM) or prazosin (30 μM). Survival is expressed as the percentage values of untreated vehicle control and values are the mean ( sem) of six independent determinations each conducted in triplicate. P<0.05, **P<0.001 compared to corresponding values for LNCap cells.
S1613	Silodosin Silodosin is a highly selective α1A-adrenoceptor antagonist, used in treatment of benign prostatic hyperplasia.
S1549	Nebivolol HCl Nebivolol HCl selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM.
S2691	BMY 7378 Dihydrochloride BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pK_i of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pK_i of 8.3.
S1424	Prazosin HCl Prazosin HCl is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia.
S2038	Phentolamine Mesylate Phentolamine Mesylate is a reversible and nonselective alpha-adrenergic receptor antagonist, used for the prevention or control of hypertensive episodes.
S1856	Metoprolol Tartrate Metoprolol Tartrate is a selective β1 receptor blocker medication, used to treat hypertension and heart failure.
S2059	Terazosin HCl Dihydrate Terazosin HCl is a selective α1-adrenoceptor antagonist, used for treatment of symptoms of an enlarged prostate (BPH).
S1387	Naftopidil DiHCl Naftopidil DiHCl is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively.
S2517	Maprotiline HCl Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression.
S1831	Carvedilol Carvedilol is a non-selective beta blocker/alpha-1 blocker, used to treat congestive heart failure (CHF) and high blood pressure.	Res Pharm Sci, 2015, 10(5):388-96
S2126	Naftopidil Naftopidil is a selective α1-adrenergic receptor antagonist with K_i of 3.7 nM, 20 nM, and 1.2 nM for α1a, α1b, and α1d, respectively, used for the treatment of benign prostatic hyperplasia.
S2499	Phenoxybenzamine HCl Phenoxybenzamine HCl is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM.
S2509	Sotalol HCl Sotalol is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM.	Toxicol Appl Pharmacol, 2015, 285(1):51-60 Gynecol Oncol, 2018, 151(3):525-532
S4123	Timolol Maleate Timolol Maleate is a non-selective, beta-adrenergic receptor antagonist for β1/β2 with K_i of 1.97 nM/2.0 nM.
S4010	Acebutolol HCl Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.
S1827	Betaxolol HCl Betaxolol is a β₁ adrenergic receptor blocker with IC50 of 6 μM.
S2607	Buflomedil HCl Buflomedil HCl is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease; A nonselective alpha adrenergic receptor inhibitor.
S3664	Flupenthixol dihydrochloride Flupentixol, an antipsychotic neuroleptic drug, is a powerful antagonist of both D1 and D2 dopamine receptors and also an alpha-adrenergic receptor antagonist.
S4124	Tolazoline HCl Tolazoline is a non-selective competitive α-adrenergic receptor antagonist.	Insect Biochem Mol Biol, 2017, 90:61-70
S4649	Atipamezole hydrochloride Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. Atipamezole hydrochloride is hydrochloride form of atipamezole.
S4650	Atipamezole Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug.
S3656	Piribedil Piribedil is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.
S4679	Terazosin HCl Terazosin is a selective alpha-1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.
S4085	Levobetaxolol HCl Levobetaxolol exhibits a higher affinity at cloned human β1 and β2 receptors with K_i value of 0.76 nM and 32.6 nM, respectively.
S5042	Bevantolol hydrochloride Bevantolol hydrochloride is a cardioselective, beta adrenoceptor antagonist, devoid of intrinsic β sympathomimetic activity and with weak membrane-stabilizing and local anesthetic properties.
S8114	ICI-118551 Hydrochloride ICI-118551 is a highly selective β2-adrenergic receptor antagonist with Ki values of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively.
S4100	Esmolol HCl Esmolol is a cardioselective b-blocker, used to control rapid heartbeats or abnormal heart rhythms.
S2091	Betaxolol Betaxolol is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.
S4278	Carteolol HCl Carteolol HCl is a β-adrenoceptor antagonist, used for the treatment of glaucoma.
S4817	Atenolol Atenolol is a selective β1 receptor antagonist with log Kd values of −6.66±0.05, −5.99±0.14, −4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors.
S2373	Yohimbine HCl Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.
S4291	Labetalol HCl Labetalol HCl is a dual antagonist for both selective alpha1-adrenergic and nonselective beta-adrenergic receptors, used in the treatment of high blood pressure.
S2507	Salbutamol Sulfate Salbutamol Sulfate is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM.	Eur J Immunol, 2016, 1948-58 Sci Rep, 2015, 5:7681	(B) Bar graphs summarize the incidence of VA from Con (An external file that holds a picture, illustration, etc. Object name is srep07681-m1.jpg) and HF (An external file that holds a picture, illustration, etc. Object name is srep07681-m2.jpg) guinea pigs before and after administration of Sal (10 μM) or Sal plus ICI (1 μM) (*p < 0.05, HF + Sal vs. Con + Sal; #p < 0.05, HF + Sal vs. HF + Sal + ICI, n = 6).
S4009	Mirabegron Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.	Andrologia, 2019, 10.1111/and.13241
S2516	Xylazine HCl Xylazine is an α2-Adrenergic receptor agonist, used as a sedative and muscle relaxant.	Biomed Rep, 2016, 5(3):357-360 Acad Radiol, 2012, 19(3):358-65 J Neurochem, 2018, 146(6):703-721
S2083^New	Procaterol HCl Procaterol HCl is a short-acting β2-adrenergic receptor agonist with K_p of 8 nM, used for the treatment of asthma
S5925^New	Olodaterol hydrochloride Olodaterol hydrochloride is the hydrochloride salt form of Olodaterol, which is a long-acting beta2-adrenergic agonist.
S5669^New	Isoxsuprine hydrochloride Isoxsuprine hydrochloride is a beta-adrenergic agonist with vasodilator activity.
S5768^New	Fenoterol hydrobromide Fenoterol hydrobromide is the the hydrobromide salt of fenoterol, a β2 adrenoreceptor agonist with bronchodilator activity.
S5769^New	Fenoterol Fenoterol is a β2 adrenoreceptor agonist with bronchodilator activity.
S5683^New	Isoproterenol sulfate dihydrate Isoproterenol Sulfate is the sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity.
S5750^New	DL-Norepinephrine hydrochloride Norepinephrine is the neurotransmitter at most sympathetic neuroeffector junctions and has pharmacologic effects on both α1 and β1 adrenoceptors.
S5751^New	Dihydroergotamine Mesylate Dihydroergotamine Mesylate is an ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors.
S9507^New	(−)-Norepinephrine (−)-Norepinephrine is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.
S9508^New	Brimonidine Brimonidine is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure.
S5564^New	Xylazine Xylazine is a partial alpha-2 adrenergic agonist that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals.
S5727^New	Tetryzoline Tetryzoline is an alpha-adrenergic agonist used in some over-the-counter eye drops and nasal sprays.
S5734^New	Midodrine hydrochloride Midodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor.
S5735^New	Midodrine Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist.
S5217^New	Arformoterol Tartrate Arformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity.
S5654^New	Indacaterol Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.
S5267^New	Nylidrin Hydrochloride Nylidrin Hydrochloride, a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well.
S5537^New	Tizanidine Tizanidine is an imidazoline derivative and a centrally acting α2 adrenergic agonist used as a muscle relaxant for therapy of acute muscle spasms and chronic spasticity.
S5494^New	Salbutamol Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases.
S5527^New	Salmeterol Salmeterol is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500).
S3083	Indacaterol Maleate Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pK_i of 7.36 for β1-adrenoceptor and pK_i of 5.48 for β2-adrenoceptor.
S2566	Isoprenaline HCl Isoprenaline is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block.
S2020	Formoterol Hemifumarate Formoterol Hemifumarate is a potent, selective and long-acting β2-adrenoceptor agonist used in the management of asthma and chronic obstructive pulmonary disease(COPD).
S2521	Epinephrine bitartrate Epinephrine bitartrate is an alpha- and beta-adrenergic receptor stimulator.
S2458	Clonidine HCl Clonidine HCl is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.
S3041	Droxidopa Droxidopa is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).
S3075	Dexmedetomidine Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.
S2522	L-Adrenaline L-Adrenaline belongs to a group of the compounds known as catecholamines.
S2569	Phenylephrine HCl Phenylephrine HCl is a selective α1-adrenergic receptor agonist, used primarily as a decongestant.	Stem Cells Dev, 2017, 26(7):528-540	(F) Fluo-4 AM-loaded EPLC-SMCs and HCASMCs displayed a change in cell surface area following phenylephrine stimulation. Scale bars, 100 μm. (G) Percentage change in cell surface area. Error bars represent SEM; n = 12 cells; **p < 0.01 versus D15 + 8 + 6 cells that did not exhibit calcium transients, analyzed by the Student's t-test. HCASMCs, human coronary artery smooth muscle cells; NS, no significant difference.
S4065	Guanabenz Acetate Guanabenz Acetate is an selective agonist of α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor with pEC50 of 8.25, 7.01 and ~5, respectively.
S2519	Naphazoline HCl Naphazoline HCl is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.
S2533	Ritodrine HCl Ritodrine HCl is a hydrochloride salt of ritodrine which is a β-2 adrenergic receptor agonist.
S2438	Synephrine HCl SynephrineHCl (Oxedrine, p-Synephrine) is a sympathomimetic α-adrenergic receptor (AR) agonist.
S2090	Dexmedetomidine HCl Dexmedetomidine HCl is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation.
S3061	Epinephrine HCl Epinephrine HCl is a hormone and a neurotransmitter.
S3060	Medetomidine HCl Medetomidine is a selective α2-adrenoceptor agonist, with K_i of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor.	Micromachines, 2018, 9(6)
S1437	Tizanidine HCl Tizanidine HCl is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.
S2092	Detomidine HCl Detomidine HCl produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors.	Nature, 2018, 560(7718):372-376
S2545	Scopine Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.
S4296	Salmeterol Xinafoate Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms.
S2523	DL-Adrenaline DL-Adrenaline is a hormone and a neurotransmitter secreted by the medulla of the adrenal glands.
S4266	Brimonidine Tartrate Brimonidine Tartrate is a highly selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma or ocular hypertension.
S3960	Higenamine hydrochloride Higenamine, also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.
S2615	Noradrenaline bitartrate monohydrate Noradrenaline bitartrate monohydrate is a direct alpha-adrenergic receptors stimulator.
S7974	L755507 L-755,507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.
S4127	Terbutaline Sulfate Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.
S4135	Clorprenaline HCl Clorprenaline HCl is a β2-receptor agonist, it has a significant expansion of the bronchial effect.
S4043	Tetrahydrozoline HCl Tetrahydrozoline HCl is an imidazoline derivative with alpha receptor agonist activity.
S2576	Xylometazoline HCl Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α_2B-adrenoceptor subtype with EC50 of 99 μM.
S3640	Methoxyphenamine Hydrochloride Methoxyphenamine Hydrochloride is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator.
S3643	Amitraz Amitraz is a triazapentadiene, an α2 adrenergic agonist and a member of the amidine chemical family. It is a non-systemic acaricide and insecticide.
S3727	Vilanterol Trifenate Vilanterol trifenatate is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma.
S4693	Guanfacine Hydrochloride Guanfacine Hydrochloride is a selective α2A-adrenoceptor agonist with anti-hypertensive effect.
S4277	Bambuterol HCl Bambuterol HCl is a potent β-adrenoceptor agonist, used in the treatment of asthma.
S2362	Synephrine Synephrine, a natural protoalkaloid in the extract of bitter orange and other citrus species, is commonly used for weight loss.
S3185	Adrenalone HCl Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors.
S9560^New	Anisodamine Hydrobromide Anisodamine is a naturally occurring atropine derivative and exhibits anti-inflammatory activity. It also inhibits α1-adrenergic receptors and muscarinic acetylcholine receptors (mAChRs).
S4243	Deoxycorticosterone acetate Deoxycorticosterone acetate is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.

Catalog No.	Information	Product Use Citations
S1324	Doxazosin Mesylate Doxazosin, a quinazoline-derivative, selectively antagonizes postsynaptic α1-adrenergic receptors, used in the treatment of high blood pressure and urinary retention associated with benign prostatic hyperplasia.	J Clin Invest, 2013, 123(12):5119-34 Antiviral Res, 2015, 120:140-6 J Ocul Pharmacol Ther, 2017, 33(1):50-56
S5703^New	Carvedilol Phosphate Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.
S5723^New	Carvedilol EP IMpurity E Carvedilol is a nonselective beta blocker/alpha-1 blocker and used in management of congestive heart failure (CHF).
S5739^New	Nebivolol Nebivolol is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.
S4076	Propranolol HCl Propranolol HCl is a competitive non-selective beta-adrenergic receptors inhibitor with IC50 of 12 nM.
S1206	Bisoprolol fumarate Bisoprolol fumarate is a selective type β1 adrenergic receptor blocker.	J Cell Mol Med, 2018, 22(12):5964-5977 J Toxicol Sci, 2017, 42(6):755-761
S4113	Desvenlafaxine Desvenlafaxine is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with K_i of 40.2 nM and 558.4 nM, respectively.
S5088	Labetalone hydrochloride Labetalone hydrochloride is hydrochloride form of labetalone, a blocker of both alpha- and beta-adrenergic receptors that is used as an antihypertensive.
S1642	Methyldopa Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.
S4112	Desvenlafaxine Succinate Desvenlafaxine Succinate is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with K_i of 40.2 nM and 558.4 nM respectively.
S2086	Ivabradine HCl Ivabradine HCl, a new I_f inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.
S2113	Cisatracurium Besylate Cisatracurium Besylate is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.

Catalog No.	Information	Product Use Citations	Product Validations
S1283	Asenapine maleate Asenapine maleate is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder.
S6447^New	Carazolol Carazolol is a non-specific β-adrenergic receptor blocking agent and binds to β receptors irreversibly.
S5942^New	Bisoprolol Bisoprolol is a cardioselective β1-adrenergic blocking agent used for secondary prevention of myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension.
S5782^New	Doxazosin Doxazosin is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors.
S5923^New	Celiprolol hydrochloride Celiprolol is a β1-adrenoceptor antagonist with partial β2 agonist activity.
S5778^New	Esmolol Esmolol is a cardioselective beta1 receptor blocker with rapid onset, a very short duration of action, and no significant intrinsic sympathomimetic or membrane stabilising activity at therapeutic dosages.
S5780^New	Prazosin Prazosin is an α1-blocker that acts as an inverse agonist at alpha-1 adrenergic receptors. It is used to treat hypertension.
S5766^New	Alfuzosin Alfuzosin, a quinazoline derivative, is a selective and competitive α1-adrenoceptor antagonist.
S5802^New	Alprenolol hydrochloride Alprenolol hydrochloride is the hydrochloride salt form of alprenolol, which is an beta adrenergic receptorantagonist and is used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.
S5666^New	Moxisylyte hydrochloride Moxisylyte hydrochloride is an alpha-adrenergic blocking agent used for the treatment of Raynaud's disease.
S9285^New	Fargesin Fargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway.
s9050^New	Boldine Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects.
S1435^New	Tamsulosin hydrochloride Tamsulosin hydrochloride is an antagonist of alpha1A adrenoceptors in the prostate.
S5540^New	Landiolol hydrochloride Landiolol hydrochloride is the hydrochloride salt form of Landiolol, which is an ultra-short-acting β1 selective adrenoceptor antagonist.
S5341^New	Metroprolol succinate Metoprolol Succinate is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity.
S5430^New	Metoprolol Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension.
S5281^New	Dapiprazole Hydrochloride Dapiprazole Hydrochloride is the hydrochloride salt form of dapiprazole, an alpha-adrenergic blocker used to reverse mydriasis after eye examination.
S5432^New	Dibenamine Hydrochloride Dibenamine is an irreversible blocker of α1 adrenoceptors.
S5337^New	Rauwolscine hydrochloride Rauwolscine hydrochloride is the hydrochloride salt form of Rauwolscine, a specific and potent α2 antagonist with Ki of 12 nM.
S1409	Alfuzosin HCl Alfuzosin HCl is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).	Prostate, 2016, 76(8):757-66	PC-3 and LNCaP cell viability following treatment with a1-adrenoceptor antagonists. (A) Cells were treated with drug (0.01-100 μM) for 72 hr and cell viability determined using the resazurin reduction assay. (B) Effect of treatment duration on PC-3 and LNCap cell survival following treatment with doxazosin (30 μM) or prazosin (30 μM). Survival is expressed as the percentage values of untreated vehicle control and values are the mean ( sem) of six independent determinations each conducted in triplicate. P<0.05, **P<0.001 compared to corresponding values for LNCap cells.
S1613	Silodosin Silodosin is a highly selective α1A-adrenoceptor antagonist, used in treatment of benign prostatic hyperplasia.
S1549	Nebivolol HCl Nebivolol HCl selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM.
S2691	BMY 7378 Dihydrochloride BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pK_i of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pK_i of 8.3.
S1424	Prazosin HCl Prazosin HCl is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia.
S2038	Phentolamine Mesylate Phentolamine Mesylate is a reversible and nonselective alpha-adrenergic receptor antagonist, used for the prevention or control of hypertensive episodes.
S1856	Metoprolol Tartrate Metoprolol Tartrate is a selective β1 receptor blocker medication, used to treat hypertension and heart failure.
S2059	Terazosin HCl Dihydrate Terazosin HCl is a selective α1-adrenoceptor antagonist, used for treatment of symptoms of an enlarged prostate (BPH).
S1387	Naftopidil DiHCl Naftopidil DiHCl is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively.
S2517	Maprotiline HCl Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression.
S1831	Carvedilol Carvedilol is a non-selective beta blocker/alpha-1 blocker, used to treat congestive heart failure (CHF) and high blood pressure.	Res Pharm Sci, 2015, 10(5):388-96
S2126	Naftopidil Naftopidil is a selective α1-adrenergic receptor antagonist with K_i of 3.7 nM, 20 nM, and 1.2 nM for α1a, α1b, and α1d, respectively, used for the treatment of benign prostatic hyperplasia.
S2499	Phenoxybenzamine HCl Phenoxybenzamine HCl is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM.
S2509	Sotalol HCl Sotalol is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM.	Toxicol Appl Pharmacol, 2015, 285(1):51-60 Gynecol Oncol, 2018, 151(3):525-532
S4123	Timolol Maleate Timolol Maleate is a non-selective, beta-adrenergic receptor antagonist for β1/β2 with K_i of 1.97 nM/2.0 nM.
S4010	Acebutolol HCl Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.
S1827	Betaxolol HCl Betaxolol is a β₁ adrenergic receptor blocker with IC50 of 6 μM.
S2607	Buflomedil HCl Buflomedil HCl is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease; A nonselective alpha adrenergic receptor inhibitor.
S3664	Flupenthixol dihydrochloride Flupentixol, an antipsychotic neuroleptic drug, is a powerful antagonist of both D1 and D2 dopamine receptors and also an alpha-adrenergic receptor antagonist.
S4124	Tolazoline HCl Tolazoline is a non-selective competitive α-adrenergic receptor antagonist.	Insect Biochem Mol Biol, 2017, 90:61-70
S4649	Atipamezole hydrochloride Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. Atipamezole hydrochloride is hydrochloride form of atipamezole.
S4650	Atipamezole Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug.
S3656	Piribedil Piribedil is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.
S4679	Terazosin HCl Terazosin is a selective alpha-1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.
S4085	Levobetaxolol HCl Levobetaxolol exhibits a higher affinity at cloned human β1 and β2 receptors with K_i value of 0.76 nM and 32.6 nM, respectively.
S5042	Bevantolol hydrochloride Bevantolol hydrochloride is a cardioselective, beta adrenoceptor antagonist, devoid of intrinsic β sympathomimetic activity and with weak membrane-stabilizing and local anesthetic properties.
S8114	ICI-118551 Hydrochloride ICI-118551 is a highly selective β2-adrenergic receptor antagonist with Ki values of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively.
S4100	Esmolol HCl Esmolol is a cardioselective b-blocker, used to control rapid heartbeats or abnormal heart rhythms.
S2091	Betaxolol Betaxolol is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.
S4278	Carteolol HCl Carteolol HCl is a β-adrenoceptor antagonist, used for the treatment of glaucoma.
S4817	Atenolol Atenolol is a selective β1 receptor antagonist with log Kd values of −6.66±0.05, −5.99±0.14, −4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors.
S2373	Yohimbine HCl Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.
S4291	Labetalol HCl Labetalol HCl is a dual antagonist for both selective alpha1-adrenergic and nonselective beta-adrenergic receptors, used in the treatment of high blood pressure.

Catalog No.	Information	Product Use Citations	Product Validations
S2507	Salbutamol Sulfate Salbutamol Sulfate is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM.	Eur J Immunol, 2016, 1948-58 Sci Rep, 2015, 5:7681	(B) Bar graphs summarize the incidence of VA from Con (An external file that holds a picture, illustration, etc. Object name is srep07681-m1.jpg) and HF (An external file that holds a picture, illustration, etc. Object name is srep07681-m2.jpg) guinea pigs before and after administration of Sal (10 μM) or Sal plus ICI (1 μM) (*p < 0.05, HF + Sal vs. Con + Sal; #p < 0.05, HF + Sal vs. HF + Sal + ICI, n = 6).
S4009	Mirabegron Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.	Andrologia, 2019, 10.1111/and.13241
S2516	Xylazine HCl Xylazine is an α2-Adrenergic receptor agonist, used as a sedative and muscle relaxant.	Biomed Rep, 2016, 5(3):357-360 Acad Radiol, 2012, 19(3):358-65 J Neurochem, 2018, 146(6):703-721
S2083^New	Procaterol HCl Procaterol HCl is a short-acting β2-adrenergic receptor agonist with K_p of 8 nM, used for the treatment of asthma
S5925^New	Olodaterol hydrochloride Olodaterol hydrochloride is the hydrochloride salt form of Olodaterol, which is a long-acting beta2-adrenergic agonist.
S5669^New	Isoxsuprine hydrochloride Isoxsuprine hydrochloride is a beta-adrenergic agonist with vasodilator activity.
S5768^New	Fenoterol hydrobromide Fenoterol hydrobromide is the the hydrobromide salt of fenoterol, a β2 adrenoreceptor agonist with bronchodilator activity.
S5769^New	Fenoterol Fenoterol is a β2 adrenoreceptor agonist with bronchodilator activity.
S5683^New	Isoproterenol sulfate dihydrate Isoproterenol Sulfate is the sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity.
S5750^New	DL-Norepinephrine hydrochloride Norepinephrine is the neurotransmitter at most sympathetic neuroeffector junctions and has pharmacologic effects on both α1 and β1 adrenoceptors.
S5751^New	Dihydroergotamine Mesylate Dihydroergotamine Mesylate is an ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors.
S9507^New	(−)-Norepinephrine (−)-Norepinephrine is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.
S9508^New	Brimonidine Brimonidine is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure.
S5564^New	Xylazine Xylazine is a partial alpha-2 adrenergic agonist that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals.
S5727^New	Tetryzoline Tetryzoline is an alpha-adrenergic agonist used in some over-the-counter eye drops and nasal sprays.
S5734^New	Midodrine hydrochloride Midodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor.
S5735^New	Midodrine Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist.
S5217^New	Arformoterol Tartrate Arformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity.
S5654^New	Indacaterol Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.
S5267^New	Nylidrin Hydrochloride Nylidrin Hydrochloride, a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well.
S5537^New	Tizanidine Tizanidine is an imidazoline derivative and a centrally acting α2 adrenergic agonist used as a muscle relaxant for therapy of acute muscle spasms and chronic spasticity.
S5494^New	Salbutamol Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases.
S5527^New	Salmeterol Salmeterol is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500).
S3083	Indacaterol Maleate Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pK_i of 7.36 for β1-adrenoceptor and pK_i of 5.48 for β2-adrenoceptor.
S2566	Isoprenaline HCl Isoprenaline is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block.
S2020	Formoterol Hemifumarate Formoterol Hemifumarate is a potent, selective and long-acting β2-adrenoceptor agonist used in the management of asthma and chronic obstructive pulmonary disease(COPD).
S2521	Epinephrine bitartrate Epinephrine bitartrate is an alpha- and beta-adrenergic receptor stimulator.
S2458	Clonidine HCl Clonidine HCl is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.
S3041	Droxidopa Droxidopa is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).
S3075	Dexmedetomidine Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.
S2522	L-Adrenaline L-Adrenaline belongs to a group of the compounds known as catecholamines.
S2569	Phenylephrine HCl Phenylephrine HCl is a selective α1-adrenergic receptor agonist, used primarily as a decongestant.	Stem Cells Dev, 2017, 26(7):528-540	(F) Fluo-4 AM-loaded EPLC-SMCs and HCASMCs displayed a change in cell surface area following phenylephrine stimulation. Scale bars, 100 μm. (G) Percentage change in cell surface area. Error bars represent SEM; n = 12 cells; **p < 0.01 versus D15 + 8 + 6 cells that did not exhibit calcium transients, analyzed by the Student's t-test. HCASMCs, human coronary artery smooth muscle cells; NS, no significant difference.
S4065	Guanabenz Acetate Guanabenz Acetate is an selective agonist of α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor with pEC50 of 8.25, 7.01 and ~5, respectively.
S2519	Naphazoline HCl Naphazoline HCl is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.
S2533	Ritodrine HCl Ritodrine HCl is a hydrochloride salt of ritodrine which is a β-2 adrenergic receptor agonist.
S2438	Synephrine HCl SynephrineHCl (Oxedrine, p-Synephrine) is a sympathomimetic α-adrenergic receptor (AR) agonist.
S2090	Dexmedetomidine HCl Dexmedetomidine HCl is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation.
S3061	Epinephrine HCl Epinephrine HCl is a hormone and a neurotransmitter.
S3060	Medetomidine HCl Medetomidine is a selective α2-adrenoceptor agonist, with K_i of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor.	Micromachines, 2018, 9(6)
S1437	Tizanidine HCl Tizanidine HCl is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.
S2092	Detomidine HCl Detomidine HCl produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors.	Nature, 2018, 560(7718):372-376
S2545	Scopine Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.
S4296	Salmeterol Xinafoate Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms.
S2523	DL-Adrenaline DL-Adrenaline is a hormone and a neurotransmitter secreted by the medulla of the adrenal glands.
S4266	Brimonidine Tartrate Brimonidine Tartrate is a highly selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma or ocular hypertension.
S3960	Higenamine hydrochloride Higenamine, also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.
S2615	Noradrenaline bitartrate monohydrate Noradrenaline bitartrate monohydrate is a direct alpha-adrenergic receptors stimulator.
S7974	L755507 L-755,507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.
S4127	Terbutaline Sulfate Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.
S4135	Clorprenaline HCl Clorprenaline HCl is a β2-receptor agonist, it has a significant expansion of the bronchial effect.
S4043	Tetrahydrozoline HCl Tetrahydrozoline HCl is an imidazoline derivative with alpha receptor agonist activity.
S2576	Xylometazoline HCl Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α_2B-adrenoceptor subtype with EC50 of 99 μM.
S3640	Methoxyphenamine Hydrochloride Methoxyphenamine Hydrochloride is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator.
S3643	Amitraz Amitraz is a triazapentadiene, an α2 adrenergic agonist and a member of the amidine chemical family. It is a non-systemic acaricide and insecticide.
S3727	Vilanterol Trifenate Vilanterol trifenatate is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma.
S4693	Guanfacine Hydrochloride Guanfacine Hydrochloride is a selective α2A-adrenoceptor agonist with anti-hypertensive effect.
S4277	Bambuterol HCl Bambuterol HCl is a potent β-adrenoceptor agonist, used in the treatment of asthma.
S2362	Synephrine Synephrine, a natural protoalkaloid in the extract of bitter orange and other citrus species, is commonly used for weight loss.
S3185	Adrenalone HCl Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors.

Catalog No.	Information	Product Use Citations	Product Validations
S9560^New	Anisodamine Hydrobromide Anisodamine is a naturally occurring atropine derivative and exhibits anti-inflammatory activity. It also inhibits α1-adrenergic receptors and muscarinic acetylcholine receptors (mAChRs).
S4243	Deoxycorticosterone acetate Deoxycorticosterone acetate is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.

Catalog No.

Information

Product Use Citations

Product Validations

S9560^New

Anisodamine Hydrobromide

Anisodamine is a naturally occurring atropine derivative and exhibits anti-inflammatory activity. It also inhibits α1-adrenergic receptors and muscarinic acetylcholine receptors (mAChRs).

S4243

Deoxycorticosterone acetate

Deoxycorticosterone acetate is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.