Adrenergic Receptor

Signaling Pathway Map

Research Area

Inhibitory Selectivity

Isoform-specific Inhibitors

Adrenergic Receptor Products

New Adrenergic Receptor Products
Catalog No. Information Product Use Citations Product Validations
S1324

Doxazosin Mesylate

Doxazosin, a quinazoline-derivative, selectively antagonizes postsynaptic α1-adrenergic receptors, used in the treatment of high blood pressure and urinary retention associated with benign prostatic hyperplasia.

S5703New

Carvedilol Phosphate

Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.

S5723New

Carvedilol EP IMpurity E

Carvedilol is a nonselective beta blocker/alpha-1 blocker and used in management of congestive heart failure (CHF).

S4076

Propranolol HCl

Propranolol HCl is a competitive non-selective beta-adrenergic receptors inhibitor with IC50 of 12 nM.

S1206

Bisoprolol fumarate

Bisoprolol fumarate is a selective type β1 adrenergic receptor blocker.

S4113

Desvenlafaxine

Desvenlafaxine is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively.

S5739

Nebivolol

Nebivolol is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.

S5088

Labetalone hydrochloride

Labetalone hydrochloride is hydrochloride form of labetalone, a blocker of both alpha- and beta-adrenergic receptors that is used as an antihypertensive.

S1642

Methyldopa

Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.

S4112

Desvenlafaxine Succinate

Desvenlafaxine Succinate is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively.

S2086

Ivabradine HCl

Ivabradine HCl, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.

S2113

Cisatracurium Besylate

Cisatracurium Besylate is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.

S1283

Asenapine maleate

Asenapine maleate is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder.

S6447New

Carazolol

Carazolol is a non-specific β-adrenergic receptor blocking agent and binds to β receptors irreversibly.

S5942New

Bisoprolol

Bisoprolol is a cardioselective β1-adrenergic blocking agent used for secondary prevention of myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension.

S5782New

Doxazosin

Doxazosin is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors.

S5923New

Celiprolol hydrochloride

Celiprolol is a β1-adrenoceptor antagonist with partial β2 agonist activity.

S5778New

Esmolol

Esmolol is a cardioselective beta1 receptor blocker with rapid onset, a very short duration of action, and no significant intrinsic sympathomimetic or membrane stabilising activity at therapeutic dosages.

S5780New

Prazosin

Prazosin is an α1-blocker that acts as an inverse agonist at alpha-1 adrenergic receptors. It is used to treat hypertension.

S5766New

Alfuzosin

Alfuzosin, a quinazoline derivative, is a selective and competitive α1-adrenoceptor antagonist.

S5802New

Alprenolol hydrochloride

Alprenolol hydrochloride is the hydrochloride salt form of alprenolol, which is an beta adrenergic receptorantagonist and is used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.

S1409

Alfuzosin HCl

Alfuzosin HCl is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).

S1613

Silodosin

Silodosin is a highly selective α1A-adrenoceptor antagonist, used in treatment of benign prostatic hyperplasia.

S1549

Nebivolol HCl

Nebivolol HCl selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM.

S2691

BMY 7378 Dihydrochloride

BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3.

S1424

Prazosin HCl

Prazosin HCl is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia.

S2038

Phentolamine Mesylate

Phentolamine Mesylate is a reversible and nonselective alpha-adrenergic receptor antagonist, used for the prevention or control of hypertensive episodes.

S1856

Metoprolol Tartrate

Metoprolol Tartrate is a selective β1 receptor blocker medication, used to treat hypertension and heart failure.

S2059

Terazosin HCl Dihydrate

Terazosin HCl is a selective α1-adrenoceptor antagonist, used for treatment of symptoms of an enlarged prostate (BPH).

S1387

Naftopidil DiHCl

Naftopidil DiHCl is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively.

S2517

Maprotiline HCl

Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression.

S1831

Carvedilol

Carvedilol is a non-selective beta blocker/alpha-1 blocker, used to treat congestive heart failure (CHF) and high blood pressure.

S2126

Naftopidil

Naftopidil is a selective α1-adrenergic receptor antagonist with Ki of 3.7 nM, 20 nM, and 1.2 nM for α1a, α1b, and α1d, respectively, used for the treatment of benign prostatic hyperplasia.

S2499

Phenoxybenzamine HCl

Phenoxybenzamine HCl is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM.

S2509

Sotalol HCl

Sotalol is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM.

S4123

Timolol Maleate

Timolol Maleate is a non-selective, beta-adrenergic receptor antagonist for β1/β2 with Ki of 1.97 nM/2.0 nM.

S4010

Acebutolol HCl

Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.

S1827

Betaxolol HCl

Betaxolol is a β1 adrenergic receptor blocker with IC50 of 6 μM.

S2607

Buflomedil HCl

Buflomedil HCl is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease; A nonselective alpha adrenergic receptor inhibitor.

S5540

Landiolol hydrochloride

Landiolol hydrochloride is the hydrochloride salt form of Landiolol, which is an ultra-short-acting β1 selective adrenoceptor antagonist.

S3664

Flupenthixol dihydrochloride

Flupentixol, an antipsychotic neuroleptic drug, is a powerful antagonist of both D1 and D2 dopamine receptors and also an alpha-adrenergic receptor antagonist.

S4124

Tolazoline HCl

Tolazoline is a non-selective competitive α-adrenergic receptor antagonist.

S5666

Moxisylyte hydrochloride

Moxisylyte hydrochloride is an alpha-adrenergic blocking agent used for the treatment of Raynaud's disease.

S9285

Fargesin

Fargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway.

S5281

Dapiprazole Hydrochloride

Dapiprazole Hydrochloride is the hydrochloride salt form of dapiprazole, an alpha-adrenergic blocker used to reverse mydriasis after eye examination.

S5337

Rauwolscine hydrochloride

Rauwolscine hydrochloride is the hydrochloride salt form of Rauwolscine, a specific and potent α2 antagonist with Ki of 12 nM.

S4649

Atipamezole hydrochloride

Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. Atipamezole hydrochloride is hydrochloride form of atipamezole.

S4650

Atipamezole

Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug.

S3656

Piribedil

Piribedil is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.

s9050

Boldine

Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects.

S1435

Tamsulosin hydrochloride

Tamsulosin hydrochloride is an antagonist of alpha1A adrenoceptors in the prostate.

S4679

Terazosin HCl

Terazosin is a selective alpha-1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.

S4085

Levobetaxolol HCl

Levobetaxolol exhibits a higher affinity at cloned human β1 and β2 receptors with Ki value of 0.76 nM and 32.6 nM, respectively.

S5042

Bevantolol hydrochloride

Bevantolol hydrochloride is a cardioselective, beta adrenoceptor antagonist, devoid of intrinsic β sympathomimetic activity and with weak membrane-stabilizing and local anesthetic properties.

S8114

ICI-118551 Hydrochloride

ICI-118551 is a highly selective β2-adrenergic receptor antagonist with Ki values of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively.

S4100

Esmolol HCl

Esmolol is a cardioselective b-blocker, used to control rapid heartbeats or abnormal heart rhythms.

S5341

Metroprolol succinate

Metoprolol Succinate is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity.

S5432

Dibenamine Hydrochloride

Dibenamine is an irreversible blocker of α1 adrenoceptors.

S2091

Betaxolol

Betaxolol is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.

S4278

Carteolol HCl

Carteolol HCl is a β-adrenoceptor antagonist, used for the treatment of glaucoma.

S5430

Metoprolol

Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension.

S4817

Atenolol

Atenolol is a selective β1 receptor antagonist with log Kd values of −6.66±0.05, −5.99±0.14, −4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors.

S2373

Yohimbine HCl

Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.

S4291

Labetalol HCl

Labetalol HCl is a dual antagonist for both selective alpha1-adrenergic and nonselective beta-adrenergic receptors, used in the treatment of high blood pressure.

S2507

Salbutamol Sulfate

Salbutamol Sulfate is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM.

S4009

Mirabegron

Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.

S2516

Xylazine HCl

Xylazine is an α2-Adrenergic receptor agonist, used as a sedative and muscle relaxant.

S6583New

Apraclonidine HCl

Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist.

S6487New

fluticasone furoate

Fluticasone furoate is an inhaled corticosteroid/long-acting beta-agonist combination with a prolonged bronchodilator duration of action. It is used for the treatment of non-allergic and allergic rhinitis administered by a nasal spray.

S2083New

Procaterol HCl

Procaterol HCl is a short-acting β2-adrenergic receptor agonist with Kp of 8 nM, used for the treatment of asthma

S5925New

Olodaterol hydrochloride

Olodaterol hydrochloride is the hydrochloride salt form of Olodaterol, which is a long-acting beta2-adrenergic agonist.

S5669New

Isoxsuprine hydrochloride

Isoxsuprine hydrochloride is a beta-adrenergic agonist with vasodilator activity.

S5768New

Fenoterol hydrobromide

Fenoterol hydrobromide is the the hydrobromide salt of fenoterol, a β2 adrenoreceptor agonist with bronchodilator activity.

S5769New

Fenoterol

Fenoterol is a β2 adrenoreceptor agonist with bronchodilator activity.

S3083

Indacaterol Maleate

Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.

S2566

Isoprenaline HCl

Isoprenaline is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block.

S2020

Formoterol Hemifumarate

Formoterol Hemifumarate is a potent, selective and long-acting β2-adrenoceptor agonist used in the management of asthma and chronic obstructive pulmonary disease(COPD).

S2521

Epinephrine bitartrate

Epinephrine bitartrate is an alpha- and beta-adrenergic receptor stimulator.

S2458

Clonidine HCl

Clonidine HCl is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.

S3041

Droxidopa

Droxidopa is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).

S3075

Dexmedetomidine

Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.

S2522

L-Adrenaline

L-Adrenaline belongs to a group of the compounds known as catecholamines.

S2569

Phenylephrine HCl

Phenylephrine HCl is a selective α1-adrenergic receptor agonist, used primarily as a decongestant.

S4065

Guanabenz Acetate

Guanabenz Acetate is an selective agonist of α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor with pEC50 of 8.25, 7.01 and ~5, respectively.

S2519

Naphazoline HCl

Naphazoline HCl is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.

S2533

Ritodrine HCl

Ritodrine HCl is a hydrochloride salt of ritodrine which is a β-2 adrenergic receptor agonist.

S2438

Synephrine HCl

SynephrineHCl (Oxedrine, p-Synephrine) is a sympathomimetic α-adrenergic receptor (AR) agonist.

S2090

Dexmedetomidine HCl

Dexmedetomidine HCl is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation.

S3061

Epinephrine HCl

Epinephrine HCl is a hormone and a neurotransmitter.

S3060

Medetomidine HCl

Medetomidine is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor.

S1437

Tizanidine HCl

Tizanidine HCl is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.

S2092

Detomidine HCl

Detomidine HCl produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors.

S5537

Tizanidine

Tizanidine is an imidazoline derivative and a centrally acting α2 adrenergic agonist used as a muscle relaxant for therapy of acute muscle spasms and chronic spasticity.

S2545

Scopine

Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.

S5527

Salmeterol

Salmeterol is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500).

S4296

Salmeterol Xinafoate

Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms.

S2523

DL-Adrenaline

DL-Adrenaline is a hormone and a neurotransmitter secreted by the medulla of the adrenal glands.

S4266

Brimonidine Tartrate

Brimonidine Tartrate is a highly selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma or ocular hypertension.

S3960

Higenamine hydrochloride

Higenamine, also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.

S2615

Noradrenaline bitartrate monohydrate

Noradrenaline bitartrate monohydrate is a direct alpha-adrenergic receptors stimulator.

S7974

L755507

L-755,507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.

S5564

Xylazine

Xylazine is a partial alpha-2 adrenergic agonist that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals.

S4127

Terbutaline Sulfate

Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.

S5683

Isoproterenol sulfate dihydrate

Isoproterenol Sulfate is the sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity.

S4135

Clorprenaline HCl

Clorprenaline HCl is a β2-receptor agonist, it has a significant expansion of the bronchial effect.

S4043

Tetrahydrozoline HCl

Tetrahydrozoline HCl is an imidazoline derivative with alpha receptor agonist activity.

S5217

Arformoterol Tartrate

Arformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity.

S5734

Midodrine hydrochloride

Midodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor.

S5735

Midodrine

Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist.

S5727

Tetryzoline

Tetryzoline is an alpha-adrenergic agonist used in some over-the-counter eye drops and nasal sprays.

S2576

Xylometazoline HCl

Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM.

S3640

Methoxyphenamine Hydrochloride

Methoxyphenamine Hydrochloride is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator.

S3643

Amitraz

Amitraz is a triazapentadiene, an α2 adrenergic agonist and a member of the amidine chemical family. It is a non-systemic acaricide and insecticide.

S3727

Vilanterol Trifenate

Vilanterol trifenatate is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma.

S4693

Guanfacine Hydrochloride

Guanfacine Hydrochloride is a selective α2A-adrenoceptor agonist with anti-hypertensive effect.

S5654

Indacaterol

Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.

S4277

Bambuterol HCl

Bambuterol HCl is a potent β-adrenoceptor agonist, used in the treatment of asthma.

S5750

DL-Norepinephrine hydrochloride

Norepinephrine is the neurotransmitter at most sympathetic neuroeffector junctions and has pharmacologic effects on both α1 and β1 adrenoceptors.

S2362

Synephrine

Synephrine, a natural protoalkaloid in the extract of bitter orange and other citrus species, is commonly used for weight loss.

S9507

(−)-Norepinephrine

(−)-Norepinephrine is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.

S9508

Brimonidine

Brimonidine is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure.

S5751

Dihydroergotamine Mesylate

Dihydroergotamine Mesylate is an ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors.

S5494

Salbutamol

Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases.

S5267

Nylidrin Hydrochloride

Nylidrin Hydrochloride, a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well.

S3185

Adrenalone HCl

Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors.

S3153New

Levalbuterol tartrate

Levalbuterol HCl is a relatively selective beta2-adrenergic receptor agonist used for the treatment of asthma.

S9560New

Anisodamine Hydrobromide

Anisodamine is a naturally occurring atropine derivative and exhibits anti-inflammatory activity. It also inhibits α1-adrenergic receptors and muscarinic acetylcholine receptors (mAChRs).

S4243

Deoxycorticosterone acetate

Deoxycorticosterone acetate is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.

Catalog No. Information Product Use Citations Product Validations
S1324

Doxazosin Mesylate

Doxazosin, a quinazoline-derivative, selectively antagonizes postsynaptic α1-adrenergic receptors, used in the treatment of high blood pressure and urinary retention associated with benign prostatic hyperplasia.

S5703New

Carvedilol Phosphate

Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.

S5723New

Carvedilol EP IMpurity E

Carvedilol is a nonselective beta blocker/alpha-1 blocker and used in management of congestive heart failure (CHF).

S4076

Propranolol HCl

Propranolol HCl is a competitive non-selective beta-adrenergic receptors inhibitor with IC50 of 12 nM.

S1206

Bisoprolol fumarate

Bisoprolol fumarate is a selective type β1 adrenergic receptor blocker.

S4113

Desvenlafaxine

Desvenlafaxine is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively.

S5739

Nebivolol

Nebivolol is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.

S5088

Labetalone hydrochloride

Labetalone hydrochloride is hydrochloride form of labetalone, a blocker of both alpha- and beta-adrenergic receptors that is used as an antihypertensive.

S1642

Methyldopa

Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.

S4112

Desvenlafaxine Succinate

Desvenlafaxine Succinate is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively.

S2086

Ivabradine HCl

Ivabradine HCl, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.

S2113

Cisatracurium Besylate

Cisatracurium Besylate is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.

Catalog No. Information Product Use Citations Product Validations
S1283

Asenapine maleate

Asenapine maleate is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder.

S6447New

Carazolol

Carazolol is a non-specific β-adrenergic receptor blocking agent and binds to β receptors irreversibly.

S5942New

Bisoprolol

Bisoprolol is a cardioselective β1-adrenergic blocking agent used for secondary prevention of myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension.

S5782New

Doxazosin

Doxazosin is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors.

S5923New

Celiprolol hydrochloride

Celiprolol is a β1-adrenoceptor antagonist with partial β2 agonist activity.

S5778New

Esmolol

Esmolol is a cardioselective beta1 receptor blocker with rapid onset, a very short duration of action, and no significant intrinsic sympathomimetic or membrane stabilising activity at therapeutic dosages.

S5780New

Prazosin

Prazosin is an α1-blocker that acts as an inverse agonist at alpha-1 adrenergic receptors. It is used to treat hypertension.

S5766New

Alfuzosin

Alfuzosin, a quinazoline derivative, is a selective and competitive α1-adrenoceptor antagonist.

S5802New

Alprenolol hydrochloride

Alprenolol hydrochloride is the hydrochloride salt form of alprenolol, which is an beta adrenergic receptorantagonist and is used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.

S1409

Alfuzosin HCl

Alfuzosin HCl is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).

S1613

Silodosin

Silodosin is a highly selective α1A-adrenoceptor antagonist, used in treatment of benign prostatic hyperplasia.

S1549

Nebivolol HCl

Nebivolol HCl selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM.

S2691

BMY 7378 Dihydrochloride

BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3.

S1424

Prazosin HCl

Prazosin HCl is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia.

S2038

Phentolamine Mesylate

Phentolamine Mesylate is a reversible and nonselective alpha-adrenergic receptor antagonist, used for the prevention or control of hypertensive episodes.

S1856

Metoprolol Tartrate

Metoprolol Tartrate is a selective β1 receptor blocker medication, used to treat hypertension and heart failure.

S2059

Terazosin HCl Dihydrate

Terazosin HCl is a selective α1-adrenoceptor antagonist, used for treatment of symptoms of an enlarged prostate (BPH).

S1387

Naftopidil DiHCl

Naftopidil DiHCl is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively.

S2517

Maprotiline HCl

Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression.

S1831

Carvedilol

Carvedilol is a non-selective beta blocker/alpha-1 blocker, used to treat congestive heart failure (CHF) and high blood pressure.

S2126

Naftopidil

Naftopidil is a selective α1-adrenergic receptor antagonist with Ki of 3.7 nM, 20 nM, and 1.2 nM for α1a, α1b, and α1d, respectively, used for the treatment of benign prostatic hyperplasia.

S2499

Phenoxybenzamine HCl

Phenoxybenzamine HCl is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM.

S2509

Sotalol HCl

Sotalol is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM.

S4123

Timolol Maleate

Timolol Maleate is a non-selective, beta-adrenergic receptor antagonist for β1/β2 with Ki of 1.97 nM/2.0 nM.

S4010

Acebutolol HCl

Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.

S1827

Betaxolol HCl

Betaxolol is a β1 adrenergic receptor blocker with IC50 of 6 μM.

S2607

Buflomedil HCl

Buflomedil HCl is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease; A nonselective alpha adrenergic receptor inhibitor.

S5540

Landiolol hydrochloride

Landiolol hydrochloride is the hydrochloride salt form of Landiolol, which is an ultra-short-acting β1 selective adrenoceptor antagonist.

S3664

Flupenthixol dihydrochloride

Flupentixol, an antipsychotic neuroleptic drug, is a powerful antagonist of both D1 and D2 dopamine receptors and also an alpha-adrenergic receptor antagonist.

S4124

Tolazoline HCl

Tolazoline is a non-selective competitive α-adrenergic receptor antagonist.

S5666

Moxisylyte hydrochloride

Moxisylyte hydrochloride is an alpha-adrenergic blocking agent used for the treatment of Raynaud's disease.

S9285

Fargesin

Fargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway.

S5281

Dapiprazole Hydrochloride

Dapiprazole Hydrochloride is the hydrochloride salt form of dapiprazole, an alpha-adrenergic blocker used to reverse mydriasis after eye examination.

S5337

Rauwolscine hydrochloride

Rauwolscine hydrochloride is the hydrochloride salt form of Rauwolscine, a specific and potent α2 antagonist with Ki of 12 nM.

S4649

Atipamezole hydrochloride

Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. Atipamezole hydrochloride is hydrochloride form of atipamezole.

S4650

Atipamezole

Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug.

S3656

Piribedil

Piribedil is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.

s9050

Boldine

Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects.

S1435

Tamsulosin hydrochloride

Tamsulosin hydrochloride is an antagonist of alpha1A adrenoceptors in the prostate.

S4679

Terazosin HCl

Terazosin is a selective alpha-1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.

S4085

Levobetaxolol HCl

Levobetaxolol exhibits a higher affinity at cloned human β1 and β2 receptors with Ki value of 0.76 nM and 32.6 nM, respectively.

S5042

Bevantolol hydrochloride

Bevantolol hydrochloride is a cardioselective, beta adrenoceptor antagonist, devoid of intrinsic β sympathomimetic activity and with weak membrane-stabilizing and local anesthetic properties.

S8114

ICI-118551 Hydrochloride

ICI-118551 is a highly selective β2-adrenergic receptor antagonist with Ki values of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively.

S4100

Esmolol HCl

Esmolol is a cardioselective b-blocker, used to control rapid heartbeats or abnormal heart rhythms.

S5341

Metroprolol succinate

Metoprolol Succinate is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity.

S5432

Dibenamine Hydrochloride

Dibenamine is an irreversible blocker of α1 adrenoceptors.

S2091

Betaxolol

Betaxolol is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.

S4278

Carteolol HCl

Carteolol HCl is a β-adrenoceptor antagonist, used for the treatment of glaucoma.

S5430

Metoprolol

Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension.

S4817

Atenolol

Atenolol is a selective β1 receptor antagonist with log Kd values of −6.66±0.05, −5.99±0.14, −4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors.

S2373

Yohimbine HCl

Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.

S4291

Labetalol HCl

Labetalol HCl is a dual antagonist for both selective alpha1-adrenergic and nonselective beta-adrenergic receptors, used in the treatment of high blood pressure.

Catalog No. Information Product Use Citations Product Validations
S2507

Salbutamol Sulfate

Salbutamol Sulfate is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM.

S4009

Mirabegron

Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.

S2516

Xylazine HCl

Xylazine is an α2-Adrenergic receptor agonist, used as a sedative and muscle relaxant.

S6583New

Apraclonidine HCl

Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist.

S6487New

fluticasone furoate

Fluticasone furoate is an inhaled corticosteroid/long-acting beta-agonist combination with a prolonged bronchodilator duration of action. It is used for the treatment of non-allergic and allergic rhinitis administered by a nasal spray.

S2083New

Procaterol HCl

Procaterol HCl is a short-acting β2-adrenergic receptor agonist with Kp of 8 nM, used for the treatment of asthma

S5925New

Olodaterol hydrochloride

Olodaterol hydrochloride is the hydrochloride salt form of Olodaterol, which is a long-acting beta2-adrenergic agonist.

S5669New

Isoxsuprine hydrochloride

Isoxsuprine hydrochloride is a beta-adrenergic agonist with vasodilator activity.

S5768New

Fenoterol hydrobromide

Fenoterol hydrobromide is the the hydrobromide salt of fenoterol, a β2 adrenoreceptor agonist with bronchodilator activity.

S5769New

Fenoterol

Fenoterol is a β2 adrenoreceptor agonist with bronchodilator activity.

S3083

Indacaterol Maleate

Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.

S2566

Isoprenaline HCl

Isoprenaline is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block.

S2020

Formoterol Hemifumarate

Formoterol Hemifumarate is a potent, selective and long-acting β2-adrenoceptor agonist used in the management of asthma and chronic obstructive pulmonary disease(COPD).

S2521

Epinephrine bitartrate

Epinephrine bitartrate is an alpha- and beta-adrenergic receptor stimulator.

S2458

Clonidine HCl

Clonidine HCl is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.

S3041

Droxidopa

Droxidopa is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).

S3075

Dexmedetomidine

Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.

S2522

L-Adrenaline

L-Adrenaline belongs to a group of the compounds known as catecholamines.

S2569

Phenylephrine HCl

Phenylephrine HCl is a selective α1-adrenergic receptor agonist, used primarily as a decongestant.

S4065

Guanabenz Acetate

Guanabenz Acetate is an selective agonist of α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor with pEC50 of 8.25, 7.01 and ~5, respectively.

S2519

Naphazoline HCl

Naphazoline HCl is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.

S2533

Ritodrine HCl

Ritodrine HCl is a hydrochloride salt of ritodrine which is a β-2 adrenergic receptor agonist.

S2438

Synephrine HCl

SynephrineHCl (Oxedrine, p-Synephrine) is a sympathomimetic α-adrenergic receptor (AR) agonist.

S2090

Dexmedetomidine HCl

Dexmedetomidine HCl is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation.

S3061

Epinephrine HCl

Epinephrine HCl is a hormone and a neurotransmitter.

S3060

Medetomidine HCl

Medetomidine is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor.

S1437

Tizanidine HCl

Tizanidine HCl is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.

S2092

Detomidine HCl

Detomidine HCl produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors.

S5537

Tizanidine

Tizanidine is an imidazoline derivative and a centrally acting α2 adrenergic agonist used as a muscle relaxant for therapy of acute muscle spasms and chronic spasticity.

S2545

Scopine

Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.

S5527

Salmeterol

Salmeterol is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500).

S4296

Salmeterol Xinafoate

Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms.

S2523

DL-Adrenaline

DL-Adrenaline is a hormone and a neurotransmitter secreted by the medulla of the adrenal glands.

S4266

Brimonidine Tartrate

Brimonidine Tartrate is a highly selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma or ocular hypertension.

S3960

Higenamine hydrochloride

Higenamine, also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.

S2615

Noradrenaline bitartrate monohydrate

Noradrenaline bitartrate monohydrate is a direct alpha-adrenergic receptors stimulator.

S7974

L755507

L-755,507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.

S5564

Xylazine

Xylazine is a partial alpha-2 adrenergic agonist that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals.

S4127

Terbutaline Sulfate

Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.

S5683

Isoproterenol sulfate dihydrate

Isoproterenol Sulfate is the sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity.

S4135

Clorprenaline HCl

Clorprenaline HCl is a β2-receptor agonist, it has a significant expansion of the bronchial effect.

S4043

Tetrahydrozoline HCl

Tetrahydrozoline HCl is an imidazoline derivative with alpha receptor agonist activity.

S5217

Arformoterol Tartrate

Arformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity.

S5734

Midodrine hydrochloride

Midodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor.

S5735

Midodrine

Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist.

S5727

Tetryzoline

Tetryzoline is an alpha-adrenergic agonist used in some over-the-counter eye drops and nasal sprays.

S2576

Xylometazoline HCl

Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM.

S3640

Methoxyphenamine Hydrochloride

Methoxyphenamine Hydrochloride is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator.

S3643

Amitraz

Amitraz is a triazapentadiene, an α2 adrenergic agonist and a member of the amidine chemical family. It is a non-systemic acaricide and insecticide.

S3727

Vilanterol Trifenate

Vilanterol trifenatate is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma.

S4693

Guanfacine Hydrochloride

Guanfacine Hydrochloride is a selective α2A-adrenoceptor agonist with anti-hypertensive effect.

S5654

Indacaterol

Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.

S4277

Bambuterol HCl

Bambuterol HCl is a potent β-adrenoceptor agonist, used in the treatment of asthma.

S5750

DL-Norepinephrine hydrochloride

Norepinephrine is the neurotransmitter at most sympathetic neuroeffector junctions and has pharmacologic effects on both α1 and β1 adrenoceptors.

S2362

Synephrine

Synephrine, a natural protoalkaloid in the extract of bitter orange and other citrus species, is commonly used for weight loss.

S9507

(−)-Norepinephrine

(−)-Norepinephrine is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.

S9508

Brimonidine

Brimonidine is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure.

S5751

Dihydroergotamine Mesylate

Dihydroergotamine Mesylate is an ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors.

S5494

Salbutamol

Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases.

S5267

Nylidrin Hydrochloride

Nylidrin Hydrochloride, a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well.

S3185

Adrenalone HCl

Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors.

Catalog No. Information Product Use Citations Product Validations
S3153New

Levalbuterol tartrate

Levalbuterol HCl is a relatively selective beta2-adrenergic receptor agonist used for the treatment of asthma.

Catalog No. Information Product Use Citations Product Validations
S9560New

Anisodamine Hydrobromide

Anisodamine is a naturally occurring atropine derivative and exhibits anti-inflammatory activity. It also inhibits α1-adrenergic receptors and muscarinic acetylcholine receptors (mAChRs).

S4243

Deoxycorticosterone acetate

Deoxycorticosterone acetate is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.

Tags: adrenergic receptor activation | adrenergic receptor types | adrenergic receptor location | adrenergic receptor drugs | adrenergic receptor signaling | adrenergic receptor pathway | beta adrenergic receptor pathway | beta adrenergic receptor activation | beta 2 adrenergic receptor activation | beta 2 adrenergic receptor pathway | alpha adrenergic receptor pathway | alpha 1 adrenergic receptor pathway | beta 1 adrenergic receptor pathway | adrenergic receptor inhibitor review