Terbutaline Sulfate

For research use only.

Catalog No.S4127

2 publications

Terbutaline Sulfate Chemical Structure

CAS No. 23031-32-5

Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.

Selleck's Terbutaline Sulfate has been cited by 2 publications

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Biological Activity

Description Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.
β2-adrenergic receptor [1]
53 nM
In vitro

Terbutaline is a relatively selective β2-adrenergic bronchodilator that has little or no effect on alpha-adrenergic receptors. The drug has exerts a preferential effect on β2-adrenergic receptors but stimulates beta-adrenergic receptors less selectively than relatively selective beta2-agonists. Terbutaline inhibits antigen-induced histamine release from passively sensitized human lung tissue, which contributes to the clinical effectiveness of the drug during treatment of allergic asthma.[1] Terbutaline also shows competitive reversible inhibition for all BChE variants. The dissociation constants for UU, FF and AA homozygotes are 0.18, 0.31 and 3.3 mM, respectively. [2]

In vivo Terbutaline appears to have a greater stimulating effect on beta-receptors of the bronchial, vascular, and uterine smooth muscles (β2 receptors) than on the beta-receptors of the heart (β1 receptors). This drug relaxes smooth muscle and inhibits uterine contractions, but may also cause some cardiostimulatory effects and CNS stimulation. [3]


Solubility (25°C)

In vitro Water 100 mg/mL (182.26 mM)
DMSO Insoluble
Ethanol Insoluble

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Chemical Information

Molecular Weight 548.65


CAS No. 23031-32-5
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)(C)NCC(C1=CC(=CC(=C1)O)O)O.CC(C)(C)NCC(C1=CC(=CC(=C1)O)O)O.OS(=O)(=O)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03976037 Completed Drug: Misoprostol Induction of Labor Christiana Care Health Services June 4 2019 Early Phase 1
NCT03140488 Completed Drug: Oxytocin Obesity|Labor Induced|Oxytocin University of Arizona June 5 2017 Phase 4
NCT02494076 Completed Drug: EzPAP|Other: Standard Care Asthma University of Colorado Denver October 2014 Phase 4
NCT00914797 Unknown status Drug: inhaled and oral terbutaline Asthma Bispebjerg Hospital|Hormone Laboratory Aker University Hospital Oslo Norway July 2009 Phase 4
NCT00782782 Unknown status -- Congestive Heart Failure Hadassah Medical Organization August 2008 --

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Adrenergic Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID