Home GPCR & G Protein Adrenergic Receptor agonist Terbutaline Sulfate

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Terbutaline Sulfate Adrenergic Receptor agonist

Cat.No.S4127

Terbutaline Sulfate(Terbutaline hemisulfate) is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.
Terbutaline Sulfate Adrenergic Receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 548.65

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Quality Control

Batch: S412701 Water]100 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.94%
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99.94

Solubility

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble
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Ethanol : Insoluble

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In vivo
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Chemical Information, Storage & Stability

Molecular Weight 548.65 Formula

C24H38N2O6.H2SO4

 Storage (From the date of receipt)
CAS No. 23031-32-5 Download SDF Storage of Stock Solutions

Synonyms Terbutaline hemisulfate Smiles CC(C)(C)NCC(C1=CC(=CC(=C1)O)O)O.CC(C)(C)NCC(C1=CC(=CC(=C1)O)O)O.OS(=O)(=O)O

Mechanism of Action

Targets/IC50/Ki
β2-adrenergic receptor
53 nM
In vitro

Terbutaline is a relatively selective β2-adrenergic bronchodilator that has little or no effect on alpha-adrenergic receptors. The drug has exerts a preferential effect on β2-adrenergic receptors but stimulates beta-adrenergic receptors less selectively than relatively selective beta2-agonists. Terbutaline inhibits antigen-induced histamine release from passively sensitized human lung tissue, which contributes to the clinical effectiveness of the drug during treatment of allergic asthma. Terbutaline also shows competitive reversible inhibition for all BChE variants. The dissociation constants for UU, FF and AA homozygotes are 0.18, 0.31 and 3.3 mM, respectively.

In vivo

Terbutaline appears to have a greater stimulating effect on beta-receptors of the bronchial, vascular, and uterine smooth muscles (β2 receptors) than on the beta-receptors of the heart (β1 receptors). This drug relaxes smooth muscle and inhibits uterine contractions, but may also cause some cardiostimulatory effects and CNS stimulation.

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06199154 Not yet recruiting
Morbid Obesity|Pregnancy
University of Maryland Baltimore
 May 2024 Early Phase 1
NCT05873218 Recruiting
Labor
Icahn School of Medicine at Mount Sinai
 June 26 2023 Phase 4
NCT03976037 Completed
Induction of Labor
Christiana Care Health Services
 June 4 2019 Early Phase 1
NCT03140488 Completed
Obesity|Labor Induced|Oxytocin
University of Arizona
 June 5 2017 Phase 4

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