Terbutaline Sulfate

Synonyms: Terbutaline hemisulfate

Terbutaline Sulfate(Terbutaline hemisulfate) is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.

Terbutaline Sulfate Chemical Structure

Terbutaline Sulfate Chemical Structure

CAS No. 23031-32-5

Purity & Quality Control

Batch: S412701 Water]100 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.94%
99.94

Terbutaline Sulfate Related Products

Biological Activity

Description Terbutaline Sulfate(Terbutaline hemisulfate) is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.
Targets
β2-adrenergic receptor [1]
53 nM
In vitro
In vitro

Terbutaline is a relatively selective β2-adrenergic bronchodilator that has little or no effect on alpha-adrenergic receptors. The drug has exerts a preferential effect on β2-adrenergic receptors but stimulates beta-adrenergic receptors less selectively than relatively selective beta2-agonists. Terbutaline inhibits antigen-induced histamine release from passively sensitized human lung tissue, which contributes to the clinical effectiveness of the drug during treatment of allergic asthma.[1] Terbutaline also shows competitive reversible inhibition for all BChE variants. The dissociation constants for UU, FF and AA homozygotes are 0.18, 0.31 and 3.3 mM, respectively. [2]

In Vivo
In vivo

Terbutaline appears to have a greater stimulating effect on beta-receptors of the bronchial, vascular, and uterine smooth muscles (β2 receptors) than on the beta-receptors of the heart (β1 receptors). This drug relaxes smooth muscle and inhibits uterine contractions, but may also cause some cardiostimulatory effects and CNS stimulation. [3]

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06199154 Not yet recruiting
Morbid Obesity|Pregnancy
University of Maryland Baltimore
May 2024 Early Phase 1
NCT05873218 Recruiting
Labor
Icahn School of Medicine at Mount Sinai
June 26 2023 Phase 4
NCT03976037 Completed
Induction of Labor
Christiana Care Health Services
June 4 2019 Early Phase 1
NCT03140488 Completed
Obesity|Labor Induced|Oxytocin
University of Arizona
June 5 2017 Phase 4

Chemical Information & Solubility

Molecular Weight 548.65 Formula

C24H38N2O6.H2SO4

CAS No. 23031-32-5 SDF Download Terbutaline Sulfate SDF
Smiles CC(C)(C)NCC(C1=CC(=CC(=C1)O)O)O.CC(C)(C)NCC(C1=CC(=CC(=C1)O)O)O.OS(=O)(=O)O
Storage (From the date of receipt)

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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