Terbutaline Sulfate

Catalog No.S4127

Terbutaline Sulfate Chemical Structure

Molecular Weight(MW): 548.65

Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.

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Biological Activity

Description Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.
Targets
β2-adrenergic receptor [1]
53 nM
In vitro

Terbutaline is a relatively selective β2-adrenergic bronchodilator that has little or no effect on alpha-adrenergic receptors. The drug has exerts a preferential effect on β2-adrenergic receptors but stimulates beta-adrenergic receptors less selectively than relatively selective beta2-agonists. Terbutaline inhibits antigen-induced histamine release from passively sensitized human lung tissue, which contributes to the clinical effectiveness of the drug during treatment of allergic asthma.[1] Terbutaline also shows competitive reversible inhibition for all BChE variants. The dissociation constants for UU, FF and AA homozygotes are 0.18, 0.31 and 3.3 mM, respectively. [2]

In vivo Terbutaline appears to have a greater stimulating effect on beta-receptors of the bronchial, vascular, and uterine smooth muscles (β2 receptors) than on the beta-receptors of the heart (β1 receptors). This drug relaxes smooth muscle and inhibits uterine contractions, but may also cause some cardiostimulatory effects and CNS stimulation. [3]

Protocol

Solubility (25°C)

In vitro Water 100 mg/mL (182.26 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 548.65
Formula

C24H38N2O6.H2SO4

CAS No. 23031-32-5
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03877874 Not yet recruiting pH Cairo University April 2019 --
NCT03877874 Not yet recruiting pH Cairo University April 2019 --
NCT03565302 Recruiting Hypertrophy|Physiologic Hypertrophy|Physical Activity Morten Hostrup PhD|University of Copenhagen June 25 2018 Not Applicable
NCT03565302 Recruiting Hypertrophy|Physiologic Hypertrophy|Physical Activity Morten Hostrup PhD|University of Copenhagen June 25 2018 Not Applicable
NCT03106753 Terminated External Cephalic Version Icahn School of Medicine at Mount Sinai April 12 2017 Phase 4
NCT03106753 Terminated External Cephalic Version Icahn School of Medicine at Mount Sinai April 12 2017 Phase 4

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Adrenergic Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID