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Tizanidine HCl

Name: Tizanidine HCl
Brand: Selleck Chemicals
SKU: S1437
Rating: 5 (1 reviews)

Synonyms: DS 103-282

Catalog No.S1437 Purity: 99.87%

Tizanidine HCl (DS 103-282) is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.

Tizanidine HCl Chemical Structure

CAS: 64461-82-1

Selleck's Tizanidine HCl has been cited by 1 publication

Purity & Quality Control

Batch: S143701 Water] 15 mg/mL] false] DMSO] 10 mg/mL] false] Ethanol] Insoluble] false Purity: 99.87%

99.87

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Signaling Pathway

Adrenergic Receptor Signaling Pathway

Choose Selective Adrenergic Receptor Inhibitors

Biological Activity

Description

Tizanidine HCl (DS 103-282) is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.

Targets

α2-adrenergic receptor ^[1]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT01844674	Completed	Malignant Melanoma Neoplasms	Hoffmann-La Roche	September 2 2013	Phase 1
NCT01839279	Completed	Spasticity	Acorda Therapeutics	April 2013	Phase 2
NCT01405950	Terminated	Spasticity Due to Cerebral Palsy	Acorda Therapeutics\|Syneos Health	May 2011	Phase 1
NCT01065987	Completed	Healthy	Dr. Reddy''s Laboratories Limited	September 2001	Phase 1

Chemical Information & Solubility

Molecular Weight	290.17	Formula	C₉H₈ClN₅S.HCl
CAS No.	64461-82-1	SDF	Download Tizanidine HCl SDF
Smiles	C1CN=C(N1)NC2=C(C=CC3=NSN=C32)Cl.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

Water : 15 mg/mL

DMSO : 10 mg/mL ( (34.46 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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