Tolazoline HCl

For research use only.

Catalog No.S4124

1 publication

Tolazoline HCl Chemical Structure

CAS No. 59-97-2

Tolazoline is a non-selective competitive α-adrenergic receptor antagonist.

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Selleck's Tolazoline HCl has been cited by 1 publication

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Biological Activity

Description Tolazoline is a non-selective competitive α-adrenergic receptor antagonist.
Targets
α-adrenergic receptor [1]
In vitro

Tolazoline is a pulmonary vasodilator indicated used to decrease pulmonary vascular resistance (PVR) in persistent pulmonary hypertension of the newborn (PPHN). Tolazoline has moderate alpha-adrenergic blocking activity and has histamine agonist activity. Tolazoline usually reduces pulmonary arterial pressure and vascular resistance.[1] Tolazoline is not as broadly effective as SNP against all spasmogens investigated. However, it may be effective in counteracting alpha-adrenoceptor-mediated vasospasm in human radial arteries. [2]

Protocol

Solubility (25°C)

In vitro DMSO 39 mg/mL (198.29 mM)
Water 39 mg/mL (198.29 mM)
Ethanol 39 mg/mL (198.29 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 196.68
Formula

C10H12N2.HCl

CAS No. 59-97-2
Storage powder
in solvent
Synonyms N/A
Smiles C1CN=C(N1)CC2=CC=CC=C2.Cl

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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