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Xylazine HCl

For research use only.

Catalog No.S2516

4 publications

Xylazine HCl Chemical Structure

CAS No. 23076-35-9

Xylazine is an α2-Adrenergic receptor agonist, used as a sedative and muscle relaxant.

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10mM (1mL in DMSO) USD 130 In stock
USD 97 In stock
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Selleck's Xylazine HCl has been cited by 4 publications

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Biological Activity

Description Xylazine is an α2-Adrenergic receptor agonist, used as a sedative and muscle relaxant.
Targets
α2-adrenergic receptor [1]
In vivo Xylazine dose-dependently inhibits norepinephrine release and lipolysis in beagle dogs. Xylazine also tends to decrease epinephrine levels dose-dependently. [1] Xylazine hydrochloride dose- and time-dependently reduces amount of minimum alveolar concentration (MAC) in horse.  Xylazine hydrochloride dose- and time-dependently increases blood glucose concentration in horse. [2] Xylazine induces variable bilateral caudal analgesia extending from coccyx to S3, with minimal sedation, ataxia, and cardiovascular and respiratory depression in standing mares. Xylazine significantly decreases heart and respiratory rates, systolic, diastolic, and mean arterial blood pressure, PCV, hemoglobin concentration, arterial oxygen content, and oxygen transport. [3] Xylazine results in significantly decreased heart rate, increased incidence of atrioventricular block, and decreased cardiac output and cardiac index in horse. [4] Xylazine induces sedation and selective (S3 to Co) analgesia for at least 2 hours in cows. Xylazine significantly decreases heart rate, respiratory rate, rate of ruminal contractions, arterial blood pressure, PaO2, PCV, and total solids concentration, and significantly increases PaCO2, base excess, and bicarbonate concentration in cows. [5] Xylazine severely depresses the N3 field (-75%) and completely abolishes the climbing fiber field (-100%) in the nonanesthetized, decerebrated rat. Xylazine- ketamine injections also severely depresses the N3 field (-75%) and nearly completely abolishes theclimbing fiber field (-90%) in the nonanesthetized, decerebrated rat.[6]

Protocol

Solubility (25°C)

In vitro DMSO 50 mg/mL (194.71 mM)
Ethanol 50 mg/mL (194.71 mM)
Water 12 mg/mL (46.73 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 256.79
Formula

C12H16N2S.HCl

CAS No. 23076-35-9
Storage powder
in solvent
Synonyms N/A
Smiles CC1=C(C(=CC=C1)C)NC2=NCCCS2.Cl

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Adrenergic Receptor Signaling Pathway Map

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