Phenylephrine HCl

Catalog No.S2569 Synonyms: NCI-c55641

Phenylephrine HCl Chemical Structure

Molecular Weight(MW): 203.67

Phenylephrine HCl is a selective α1-adrenergic receptor agonist, used primarily as a decongestant.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Cited by 1 Publication

1 Customer Review

  • (F) Fluo-4 AM-loaded EPLC-SMCs and HCASMCs displayed a change in cell surface area following phenylephrine stimulation. Scale bars, 100 μm. (G) Percentage change in cell surface area. Error bars represent SEM; n = 12 cells; **p < 0.01 versus D15 + 8 + 6 cells that did not exhibit calcium transients, analyzed by the Student's t-test. HCASMCs, human coronary artery smooth muscle cells; NS, no significant difference.

    Stem Cells Dev, 2017, 26(7):528-540. Phenylephrine HCl purchased from Selleck.

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Biological Activity

Description Phenylephrine HCl is a selective α1-adrenergic receptor agonist, used primarily as a decongestant.
Targets
α1-adrenergic receptor [1]
In vitro

Phenylephrine causes a rapid translocation of PKC-epsilon (EC50 = 0.9 mM) but the proportion lost from the soluble fraction is less than with ET-1. [1] Phenylephrine at pCa 7 causes a dose-dependent increase in contractile force of the hyperpermeable cells, which is reversible on addition of phentolamine. [2] Phenylephrine also protects cardiomyocytes against subsequent 24 h treatment with hypoxia and serum deprivation. Phenylephrine prevents the down-regulation of Bcl-2 and Bcl-X mRNA/protein and induces hypertrophic growth. Phenylephrine-mediated protection is abrogated by the phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor wortmannin and is mimicked by the caspase-9 peptidic inhibitor LEHD-fmk. [3] Phenylephrine stimulates phosphoinositide (PI) hydrolysis, cell growth, and expression of several genes [e.g., atrial natriuretic factor (ANF)] often associated with cardiac hypertrophy. [4] Phenylephrine (1 礛) markedly potentiates HGF-induced hepatocyte DNA synthesis and proliferation. [5] Phenylephrine (10 mM) reversibly increases I(Ca,L) (51.3%; n = 40) and shifted peak I(Ca,L) activation voltage by -10 mV. Phenylephrine also increases local, subsarcolemmal SR Ca2+ release via IP3-dependent signaling. Phenylephrin-induced NOi release requires stimulation of both PI-3K/Akt and IP3-dependent Ca2+ signaling. Phenylephrine-induced NOi release is inhibited by each of 1 mM prazocin, 10 mM L-NIO, 10 mM W-7, 10 mM LY294002, 2 mM H-89, 10 mM ryanodine, 5 mM thapsigargin, 2 mM 2-APB or 10 mM xestospongin C. [6]

Protocol

Solubility (25°C)

In vitro DMSO 41 mg/mL (201.3 mM)
Water 41 mg/mL (201.3 mM)
Ethanol 41 mg/mL (201.3 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 203.67
Formula

C9H13NO2.HCl

CAS No. 61-76-7
Storage powder
in solvent
Synonyms NCI-c55641

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03864094 Not yet recruiting Hemodynamic Instability|Anesthesia General|Anesthesia Intravenous Helse Fonna March 2021 Phase 4
NCT03864094 Not yet recruiting Hemodynamic Instability|Anesthesia General|Anesthesia Intravenous Helse Fonna March 2021 Phase 4
NCT03872570 Not yet recruiting Arterial Hypotension Algemeen Ziekenhuis Maria Middelares June 1 2019 Phase 4
NCT03872570 Not yet recruiting Arterial Hypotension Algemeen Ziekenhuis Maria Middelares June 1 2019 Phase 4
NCT03846765 Not yet recruiting Nfuence of Vasoactive Medication on Spinal Oxygenation University Hospital Ghent March 2019 Phase 4
NCT03846765 Not yet recruiting Nfuence of Vasoactive Medication on Spinal Oxygenation University Hospital Ghent March 2019 Phase 4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID