Propranolol HCl

Catalog No.S4076 Synonyms: AY-64043, ICI-45520, NCS-91523

Propranolol HCl Chemical Structure

Molecular Weight(MW): 295.8

Propranolol HCl is a competitive non-selective beta-adrenergic receptors inhibitor with IC50 of 12 nM.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Purity & Quality Control

Choose Selective Adrenergic Receptor Inhibitors

Biological Activity

Description Propranolol HCl is a competitive non-selective beta-adrenergic receptors inhibitor with IC50 of 12 nM.
Targets
β-adrenergic receptor [1]
12 nM
Assay
Methods Test Index PMID
Growth inhibition assay
Cell viability; 

PubMed: 27582542     


A-C. Cell viability was determined following treatment with increasing propranolol concentration (25, 50, 100, 200, 400 μM) for 24h, 48h and 72h by AlamarBlue® Cell Viability Assay, relative growth was calculated as the ratio of treated to untreated cells at each dose for each replicate. D. IC50 of propranolol after a 24h, 48h and 72h incubation in the four cell lines, respectively. ****P<0.0001. All experiments were repeated for at least three times independently.

27582542
Western blot
Bax / Bcl-2 / Cyt C / Caspase-9 / Cleaved Caspase-9 / Caspase-3 / Cleaved Caspase-3; 

PubMed: 27582542     


A-E. The expressions of Bax, Bcl-2, cytochrome c, caspase-9 and caspase-3 following exposure to propranolol 100 μM for 24h in A375, P-3 and P-6 cell lines. Aa-Ec. Quantification of A-D. Results are presented as mean±SEM, *P<0.05, ***P<0.001, ****P<0.0001. All experiments were repeated for at least three times independently.

B-Raf / p-B-Raf / MEK / p-MEK / ERK / p-ERK / AKT / p-AKT ; 

PubMed: 27582542     


A-D. BRAF, MEK1/2, ERK1/2 and AKT phosphorylation following treatment with propranolol 100 μM for 24h in A375, P-3 and P-6 cell lines. Aa-Df, Quantification of A-D. Results are presented as mean±SEM, *P<0.05, **P<0.01,***P<0.001, ****P<0.0001. All experiments were repeated for at least three times independently.

27582542

Protocol

Solubility (25°C)

In vitro DMSO 59 mg/mL (199.45 mM)
Water 6 mg/mL (20.28 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 295.8
Formula

C16H21NO2.HCl

CAS No. 318-98-9
Storage powder
in solvent
Synonyms AY-64043, ICI-45520, NCS-91523

Bio Calculators

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03926663 Recruiting Drug: Dexmedetomidine|Drug: Bupivacaine Intranasal Dexmedetomidine|Intranasal Bupivacaine|Septoplasty Surgeries Cairo University July 20 2019 Phase 4
NCT03524066 Completed Drug: Inhalation|Drug: Systemic|Other: Bronchoscopy Healthy Fraunhofer-Institute of Toxicology and Experimental Medicine|AstraZeneca April 10 2018 Not Applicable
NCT03474614 Recruiting Drug: Propranolol|Genetic: DNA and RNA Analysis Cerebral Cavernous Malformations St. Joseph''s Hospital and Medical Center Phoenix January 24 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Adrenergic Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID