Prazosin HCl

Licensed by Pfizer Catalog No.S1424 Synonyms: cp-12299-1

Prazosin HCl Chemical Structure

Molecular Weight(MW): 419.86

Prazosin HCl is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia.

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Biological Activity

Description Prazosin HCl is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia.
Targets
alpha-adrenergic receptor [1]
In vitro

Prazosin leads to a significant increase in VEGF concentration in endothelial cells and angiogenesis only if eNOS is present. Prazosin binds to the α1-adrenergic receptors that are present on smooth muscle cells surrounding all larger blood vessels. [1] Prazosin (0.1 nM) blocks the increases in perfusion pressure caused by electrical stimulation of the perimesenteric nerves but does not significantly reduce the vasomotor effect of exogenous noradrenaline. [2]

In vivo Prazosin application leads to the expansion of the capillary system by modulation of the hemodynamic environment (flow rate, shear stress) in skeletal muscle. Prazosin induces angiogenesis in extensor digitorum longus (EDL) muscles of C57BL/6 mice but not eNOS-knockout mice. [1] Prazosin (0.5-2.0 mg/kg) blocks Yohimbine-induced reinstatement of food and alcohol seeking, as well as footshock-induced reinstatement of alcohol seeking in rats. [3] Prazosin (0.2mg kg(-1) s.c.) causes an enhancement of a suppression of conditioned avoidance response in the presence of the dopamine D2 receptor antagonist raclopride (0.05-0.20 mg/kg s.c.) in rats. [4] Prazosin administration alone (1 mg/kg, s.c.) only slightly reduces horizontal activity during an initial 10 min measurement period, although it consistently reduces rearing in freely moving rats. Prazosin effectively suppresses the locomotor stimulation caused by either dose of MK-801 throughout the whole observation period in freely moving rats. [5]

Protocol

Solubility (25°C)

In vitro DMSO 4 mg/mL warmed (9.52 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 419.86
Formula

C19H21N5O4·HCl

CAS No. 19237-84-4
Storage powder
in solvent
Synonyms cp-12299-1

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03710642 Recruiting Alzheimer''s Disease|Disruptive Behavior Alzheimer''s Disease Cooperative Study (ADCS)|National Institute on Aging (NIA)|VA Puget Sound Health Care System March 30 2019 Phase 2
NCT03710642 Recruiting Alzheimer''s Disease|Disruptive Behavior Alzheimer''s Disease Cooperative Study (ADCS)|National Institute on Aging (NIA)|VA Puget Sound Health Care System March 30 2019 Phase 2
NCT03539614 Recruiting Posttraumatic Stress Disorder VA Office of Research and Development June 4 2018 Phase 3
NCT03539614 Recruiting Posttraumatic Stress Disorder VA Office of Research and Development June 4 2018 Phase 3
NCT03416569 Withdrawn no Condition Basic Science University of Maryland March 2018 Not Applicable
NCT03416569 Withdrawn no Condition Basic Science University of Maryland March 2018 Not Applicable

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Adrenergic Receptor Signaling Pathway Map

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