Xylometazoline HCl

For research use only.

Catalog No.S2576

Xylometazoline HCl Chemical Structure

CAS No. 1218-35-5

Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM.

Size Price Stock Quantity  
10mM (1mL in DMSO) EUR 127 In stock
EUR 77 In stock
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Biological Activity

Description Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM.
Targets
adrenoceptor α1A [1] adrenoceptor α2C [1] adrenoceptor α1D [1] adrenoceptor α1B [1] adrenoceptor α2A [1]
80 nM 220 nM 450 nM 560 nM 980 nM
In vitro

Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. Xylometazoline binds at adrenoceptor subtypeα1A, α1B, α1D, α2A, α2B, α2C with IC50 of 0.08, 0.56, 0.45, 0.98, 1.8, 0.22μM, repectively. [1]

Protocol

Solubility (25°C)

In vitro Water 56 mg/mL (199.4 mM)
Ethanol 56 mg/mL (199.4 mM)
DMSO 27 mg/mL (96.14 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 280.84
Formula

C16H24N2.HCl

CAS No. 1218-35-5
Storage powder
in solvent
Synonyms N/A
Smiles CC1=CC(=CC(=C1CC2=NCCN2)C)C(C)(C)C.Cl

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00452270 Completed Drug: Xylometazoline Common Cold Novartis March 2007 Phase 3

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Adrenergic Receptor Signaling Pathway Map

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