YS-49

YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells, inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1, also is an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors.

YS-49 Chemical Structure

YS-49 Chemical Structure

CAS: 132836-42-1

Purity & Quality Control

Batch: Purity: 99.81%
99.81

YS-49 Related Products

Signaling Pathway

Choose Selective PI3K Inhibitors

Biological Activity

Description YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells, inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1, also is an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors.
Targets
PI3K [1] Akt [1] cardiac β-adrenoceptors [3]

Chemical Information & Solubility

Molecular Weight 386.28 Formula

C20H19NO2.BrH

CAS No. 132836-42-1 SDF --
Smiles Br.OC1=CC2=C(C=C1O)C(CC3=C4C=CC=CC4=CC=C3)NCC2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 77 mg/mL ( (199.33 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 77 mg/mL

Water : 6 mg/mL


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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