Catalog No.S3041 Synonyms: L-DOPS
Molecular Weight(MW): 213.19
Droxidopa is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).
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|Description||Droxidopa is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).|
|Features||An artificial amino acid.|
Droxidopa is a pro-drug which has a structure similar to noradrenaline, but with a carboxyl group. Droxidopa can be administered orally, unlike noradrenaline, and after absorption is converted by the enzyme dopa decarboxylase into noradrenaline thus increasing levels of the neurotransmitter which is identical to endogenous noradrenaline.  Droxidopa is well tolerated.  Droxidopa could exert its pressor effect in three different ways: a) as a central stimulator of sympathetic activity; b) as a peripheral sympathetic neurotransmitter; c) as a circulating hormone. Droxidopa taken alone increases standing blood pressure.  Droxidopa can also cross the blood–brain barrier (BBB) where it is converted to norepinephrine and epinephrine from within the brain. 
|In vivo||The acute administration of droxidopa in PVL and BDL rats caused a significant and maintained increase in arterial pressure and mesenteric arterial resistance, with a significant decrease of mesenteric arterial and portal blood flow, without changing portal pressure and renal blood flow. Droxidopa-treated rats also showed a decreased ratio of p-eNOS/eNOS and p-AKT/AKT and increased activity of RhoK in SMA.|
-  Mathias CJ. Clin Auton Res, 2008, 18 Suppl 1, 25-29.
-  Mathias CJ, et al. Clin Auton Res, 2001, 11(4), 235-242.
-  Kaufmann H. Clin Auton Res, 2008, 18 Suppl 1, 19-24.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03446807||Not yet recruiting||Drug: Droxidopa|Drug: Placebo Oral Tablet||Parkinson Disease|Multiple System Atrophy|Progressive Supranuclear Palsy||Loma Linda University|H. Lundbeck A/S||April 2018||Phase 2|
|NCT03173781||Completed||Drug: droxidopa|Drug: Placebo||Parkinson''s Disease||Colorado Springs Neurological Associates|H. Lundbeck A/S||April 2016||Not Applicable|
|NCT01331122||Withdrawn||Drug: droxidopa||Gait Disorders Neurologic||Chelsea Therapeutics||April 2012||Phase 1|Phase 2|
|NCT01370512||Recruiting||Drug: Droxidopa|Drug: Pyridostigmine Bromide||Orthostatic Hypotension||Mayo Clinic||November 2011||Phase 2|
|NCT01354158||Completed||Drug: Droxidopa||Spinal Cord Injury|Hypotension||Bronx VA Medical Center|Chelsea Therapeutics||May 2011||Phase 1|
|NCT01327066||Completed||Drug: Droxidopa|Drug: Moxifloxacin|Drug: Placebo||QTc Interval||Chelsea Therapeutics||March 2011||Phase 1|
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