For research use only.
Catalog No.S3041 Synonyms: L-DOPS
CAS No. 23651-95-8
Droxidopa (L-DOPS) is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).
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|Description||Droxidopa (L-DOPS) is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).|
|Features||An artificial amino acid.|
Droxidopa is a pro-drug which has a structure similar to noradrenaline, but with a carboxyl group. Droxidopa can be administered orally, unlike noradrenaline, and after absorption is converted by the enzyme dopa decarboxylase into noradrenaline thus increasing levels of the neurotransmitter which is identical to endogenous noradrenaline.  Droxidopa is well tolerated.  Droxidopa could exert its pressor effect in three different ways: a) as a central stimulator of sympathetic activity; b) as a peripheral sympathetic neurotransmitter; c) as a circulating hormone. Droxidopa taken alone increases standing blood pressure.  Droxidopa can also cross the blood–brain barrier (BBB) where it is converted to norepinephrine and epinephrine from within the brain. 
|In vivo||The acute administration of droxidopa in PVL and BDL rats caused a significant and maintained increase in arterial pressure and mesenteric arterial resistance, with a significant decrease of mesenteric arterial and portal blood flow, without changing portal pressure and renal blood flow. Droxidopa-treated rats also showed a decreased ratio of p-eNOS/eNOS and p-AKT/AKT and increased activity of RhoK in SMA.|
-  Mathias CJ. Clin Auton Res, 2008, 18 Suppl 1, 25-29.
-  Mathias CJ, et al. Clin Auton Res, 2001, 11(4), 235-242.
-  Kaufmann H. Clin Auton Res, 2008, 18 Suppl 1, 19-24.
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|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
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|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03446807||Not yet recruiting||Drug: Droxidopa|Drug: Placebo Oral Tablet||Parkinson Disease|Multiple System Atrophy|Progressive Supranuclear Palsy||Loma Linda University|H. Lundbeck A/S||December 2021||Phase 2|
|NCT04977388||Recruiting||Drug: Droxidopa|Other: Placebo||Menkes Disease|Occipital Horn Syndrome||Stephen G. Kaler MD|Nationwide Children''s Hospital||July 12 2021||Phase 1|Phase 2|
|NCT03173781||Completed||Drug: droxidopa|Drug: Placebo||Parkinson''s Disease||Colorado Springs Neurological Associates|H. Lundbeck A/S||April 2016||Not Applicable|
|NCT01331122||Withdrawn||Drug: droxidopa||Gait Disorders Neurologic||Chelsea Therapeutics||April 2012||Phase 1|Phase 2|
|NCT01370512||Completed||Drug: Droxidopa|Drug: Pyridostigmine Bromide||Orthostatic Hypotension||Mayo Clinic|National Institute of Neurological Disorders and Stroke (NINDS)||November 2011||Phase 2|
|NCT01354158||Completed||Drug: Droxidopa||Spinal Cord Injury|Hypotension||Bronx VA Medical Center|Chelsea Therapeutics||May 2011||Phase 1|
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