Droxidopa
Catalog No.S3041 Synonyms: L-DOPS
Molecular Weight(MW): 213.19
Droxidopa is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).
Purity & Quality Control
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Biological Activity
| Description | Droxidopa is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). | ||||||||||||||||
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| Features | An artificial amino acid. | ||||||||||||||||
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| In vitro |
Droxidopa is a pro-drug which has a structure similar to noradrenaline, but with a carboxyl group. Droxidopa can be administered orally, unlike noradrenaline, and after absorption is converted by the enzyme dopa decarboxylase into noradrenaline thus increasing levels of the neurotransmitter which is identical to endogenous noradrenaline. [1] Droxidopa is well tolerated. [2] Droxidopa could exert its pressor effect in three different ways: a) as a central stimulator of sympathetic activity; b) as a peripheral sympathetic neurotransmitter; c) as a circulating hormone. Droxidopa taken alone increases standing blood pressure. [3] Droxidopa can also cross the blood–brain barrier (BBB) where it is converted to norepinephrine and epinephrine from within the brain. [4] |
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| Cell Data |
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| In vivo | The acute administration of droxidopa in PVL and BDL rats caused a significant and maintained increase in arterial pressure and mesenteric arterial resistance, with a significant decrease of mesenteric arterial and portal blood flow, without changing portal pressure and renal blood flow. Droxidopa-treated rats also showed a decreased ratio of p-eNOS/eNOS and p-AKT/AKT and increased activity of RhoK in SMA[5]. |
Protocol
| Animal Research: |
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Solubility (25°C)
| In vitro | DMSO | Insoluble |
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| Water | Insoluble | |
| Ethanol | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 213.19 |
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| Formula | C9H11NO5 |
| CAS No. | 23651-95-8 |
| Storage | powder |
| in solvent | |
| Synonyms | L-DOPS |
Bio Calculators
Molarity Calculator
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
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Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT03567447 | Recruiting | Parkinson Disease|Falls Patient | St. Joseph''s Hospital and Medical Center Phoenix|H. Lundbeck A/S|Arizona State University | August 17 2018 | Phase 2 |
| NCT03229174 | Recruiting | Parkinson Disease|Neurogenic Orthostatic Hypotension | William Ondo MD|Lundbeck LLC|The Methodist Hospital System | August 23 2018 | Phase 4 |
| NCT03567447 | Recruiting | Parkinson Disease|Falls Patient | St. Joseph''s Hospital and Medical Center Phoenix|H. Lundbeck A/S|Arizona State University | August 17 2018 | Phase 2 |
| NCT03229174 | Recruiting | Parkinson Disease|Neurogenic Orthostatic Hypotension | William Ondo MD|Lundbeck LLC|The Methodist Hospital System | August 23 2018 | Phase 4 |
| NCT03446807 | Not yet recruiting | Parkinson Disease|Multiple System Atrophy|Progressive Supranuclear Palsy | Loma Linda University|H. Lundbeck A/S | April 2018 | Phase 2 |
| NCT03446807 | Not yet recruiting | Parkinson Disease|Multiple System Atrophy|Progressive Supranuclear Palsy | Loma Linda University|H. Lundbeck A/S | April 2018 | Phase 2 |
Tech Support
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