For research use only.
Catalog No.S3041 Synonyms: L-DOPS
Molecular Weight(MW): 213.19
Droxidopa is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).
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|Description||Droxidopa is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).|
|Features||An artificial amino acid.|
Droxidopa is a pro-drug which has a structure similar to noradrenaline, but with a carboxyl group. Droxidopa can be administered orally, unlike noradrenaline, and after absorption is converted by the enzyme dopa decarboxylase into noradrenaline thus increasing levels of the neurotransmitter which is identical to endogenous noradrenaline.  Droxidopa is well tolerated.  Droxidopa could exert its pressor effect in three different ways: a) as a central stimulator of sympathetic activity; b) as a peripheral sympathetic neurotransmitter; c) as a circulating hormone. Droxidopa taken alone increases standing blood pressure.  Droxidopa can also cross the blood–brain barrier (BBB) where it is converted to norepinephrine and epinephrine from within the brain. 
|In vivo||The acute administration of droxidopa in PVL and BDL rats caused a significant and maintained increase in arterial pressure and mesenteric arterial resistance, with a significant decrease of mesenteric arterial and portal blood flow, without changing portal pressure and renal blood flow. Droxidopa-treated rats also showed a decreased ratio of p-eNOS/eNOS and p-AKT/AKT and increased activity of RhoK in SMA.|
-  Mathias CJ. Clin Auton Res, 2008, 18 Suppl 1, 25-29.
-  Mathias CJ, et al. Clin Auton Res, 2001, 11(4), 235-242.
-  Kaufmann H. Clin Auton Res, 2008, 18 Suppl 1, 19-24.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03446807||Not yet recruiting||Drug: Droxidopa|Drug: Placebo Oral Tablet||Parkinson Disease|Multiple System Atrophy|Progressive Supranuclear Palsy||Loma Linda University|H. Lundbeck A/S||January 2020||Phase 2|
|NCT03173781||Completed||Drug: droxidopa|Drug: Placebo||Parkinson''s Disease||Colorado Springs Neurological Associates|H. Lundbeck A/S||April 2016||Not Applicable|
|NCT01331122||Withdrawn||Drug: droxidopa||Gait Disorders Neurologic||Chelsea Therapeutics||April 2012||Phase 1|Phase 2|
|NCT01370512||Recruiting||Drug: Droxidopa|Drug: Pyridostigmine Bromide||Orthostatic Hypotension||Mayo Clinic||November 2011||Phase 2|
|NCT01354158||Completed||Drug: Droxidopa||Spinal Cord Injury|Hypotension||Bronx VA Medical Center|Chelsea Therapeutics||May 2011||Phase 1|
|NCT01327066||Completed||Drug: Droxidopa|Drug: Moxifloxacin|Drug: Placebo||QTc Interval||Chelsea Therapeutics||March 2011||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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