Home Neuronal Signaling Adrenergic Receptor antagonist - 5-HT Receptor agonist Urapidil

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Urapidil Adrenergic Receptor antagonist

Cat.No.S5965

Urapidil is an antihypertensive drug acting as an α1 adrenoreceptor antagonist and a 5-HT1A agonist.
Urapidil Adrenergic Receptor antagonist Chemical Structure

Chemical Structure

Molecular Weight: 387.48

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Quality Control

Batch: S596501 DMSO]77 mg/mL]false]Ethanol]77 mg/mL]false]Water]Insoluble]false Purity: 99.95%
99.95

Chemical Information, Storage & Stability

Molecular Weight 387.48 Formula

C20H29N5O3

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 34661-75-1 -- Storage of Stock Solutions

Synonyms N/A Smiles COC1=CC=CC=C1N2CCN(CCCNC3=CC(=O)N(C)C(=O)N3C)CC2

Solubility

In vitro
Batch:

DMSO : 77 mg/mL ( (198.71 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 77 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
α1 adrenoreceptor [1]
5-HT1A [1]
In vivo

Urapidil alleviates ovarian torsion detorsion injury via regulating oxidative stress, apoptosis, autophagia, and inflammation.[2]
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03076099 Unknown status
Anesthesia
Nan Jiang|First Affiliated Hospital Sun Yat-Sen University
 January 1 2016 Not Applicable
NCT05537194 Completed
Hypoxia
University Hospital Caen
 January 1 1963 --

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