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Propafenone Sodium Channel inhibitor

Cat.No.S5789

Propafenone (SA-79) is an orally active sodium channel blocking agent and a beta-adrenoceptor (β-adrenergic receptor) antagonist. This compound offers a broad spectrum of activity in the treatment of cardiac arrhythmias.It can be used to induce animal models of Heart Failure.
Propafenone Sodium Channel inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 341.44

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Quality Control

Batch: S578901 DMSO]68 mg/mL]false]Ethanol]41 mg/mL]false]Water]Insoluble]false Purity: 99.90%
99.90

Solubility

In vitro
Batch:

DMSO : 68 mg/mL (199.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 41 mg/mL

Water : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 341.44 Formula

C21H27NO3

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 54063-53-5 -- Storage of Stock Solutions

Synonyms SA-79 Smiles CCCNCC(O)COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2

Mechanism of Action

Targets/IC50/Ki
sodium channel
β-adrenergic receptor
In vitro

Application of 10 µM propafenone decreases the Kv currents by 51%, as measured at +60 mV.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03915340 Completed
Bioequivalence
Pharmtechnology LLC|Altasciences Company Inc.
 March 23 2019 Phase 1
NCT03029169 Completed
Supraventricular Arrhythmia|Septic Shock
Charles University Czech Republic
 October 23 2017 Phase 4

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